To report about occurence of side effects of different antidepressants during treatment of a patient with depressive disorder.

Patient, 42 years old, was admitted to our Clinic for psychiatry due to worsening in her mental condition. At admission, the patient was anxious, depressed, and members of her family said that she stopped eating and isolated herself from her family and other people. Also, she spent most of the time in bed. After admission to the hospital the laboratory examination was performed and results were in referent ranges. Also, EEG and brain MRI were performed (normal findings). The patient was diagnosed with depressive disorder. The treatment with duloxetine in daily dosage of 30 mg, along with lorazepam in daily dosage of 2,5 mg was initiated, but vomiting occured and the treatment with duloxetine was discontinued. After that velafaxine was introduced in therapy. Soon after that headache occured and treatment with venlafaxine was discontinued. The therapy with tianeptine in daily dosage of 37,5 mg was initiated and after two weeks the symptoms of depression and anxiety were reduced. Also, the patient started communicating more with other people and showed interest in the environment. Gradually, daily dosage of lorazepam was reduced and treatment with lorazepam was discontinued. The patient was discharged from the hospital after six weeks of treatment. At control examinations that followed her mental condition remained stable and she started work again.