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P-200 - Mood Spectrum and Depersonalization Symptoms in Unipolar and Bipolar Patients

Published online by Cambridge University Press:  15 April 2020

M. Preve ,
M. Mula ,
S. Calugi ,
S. Pini  and
M. Mauri
M. Preve
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa
M. Mula
Affiliation:
Department of Clinical & Experimental Medicine, Amedeo Avogadro University, Novara, Italy
S. Calugi
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa
S. Pini
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa
M. Mauri
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa

Abstract

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Introduction:

Prevalence and clinical correlates of dissociative symptoms in general, and depersonalization (DP) in particular, in patients with mood disorders have received limited attention in the literature1. Thus, the aim ofour study is to evaluate the association between depersonalization symptoms and mood dimensions in a sample of unipolar (UD) and bipolar (BD) patients.

Method:

185 patients (95 BD and 90 UD) in eutimic phase (evaluate with YMRS and HDRS) are assessed with: SCID-P for axis I diagnosis, HDRS, YMRS, MOOD-SR-lifetime version2 and SCI-DER.

Results:

through a regression analysis we underline in UD patients that the presence of depersonalization symptoms is significantly associated with the following mood dimensions: psychomotor retardation (p = 0.031; B = 2,197), mixed irritability (p = 0.035; B = 2,137) and social extroversion (p = 0.028; B = -2,229). We found no significat association in the group of BD patients.

Conclusion:

In UD patiens, the presence of depersonalization symptoms must carefully consider. Further research are needed to identify specific clinical endophenotypes3.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012

References

Reference:

Mula, M., et al. J Affect Disord 2008Google Scholar
Cassano, G.B., et al. J Affect Disord 2008Google Scholar
Mula, M.., et al. Compr Psychiatry 2010Google Scholar
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