The association between seizures freedom and the occurrence of psychotic symptoms or changes in the mental state has long been known. the forced normalization phenomenon of epilepsy, first described by Landolt's, assumes that the recurrence of psychotic states is attached to the normalization of electroencephalogram (EEG) findings. in addiction, Tellenbach coined as Alternative Psychosis the conditions in which patients were psychotic when their seizures were controlled and experienced psychosis’ resolution after the return of seizures. Clinically, such form of postictal psychosis has been characterized by cloudiness of consciousness and a pleomorphic presentation involving affective and psychotic symptoms, with a rather variable course. Although the growing evidences in this field, few case reports have been published in the last years. in this work the authors propose to report the case of an 22-year-old mild mentally retarded women, with recurrent refractory tonic-clonic epilepsy, who developed sudden behavioural changes (dysphoria, psychomotor agitation, and aggressive outbursts) after the beginning of a new poly-antiepileptic drug regimen which was successful in normalizing the EEG and completely ceasing the seizure episodes. They conclude about the clinicians’ need of being more aware of the conditions overlapping both psychiatry and neurology and draw attention to the importance of the interdisciplinarity and case discussion between these two medical specialities.