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Perceived negative attitude of others predicts transition to psychosis in patients at risk of psychosis

Published online by Cambridge University Press:  15 April 2020

R.K.R. Salokangas ,
P. Patterson ,
M. Heinimaa ,
T. Svirskis ,
T. From ,
L. Vaskelainen ,
J. Klosterkötter ,
S. Ruhrmann ,
H.G. von Reventlow  and
G. Juckel
...Show all authors
R.K.R. Salokangas*
Affiliation:
Department of Psychiatry, University of Turku, 20520Turku, Finland Psychiatric Clinic, Turku University Central Hospital, Turku, Finland Turku Psychiatric Clinic, Turku Mental Health Centre, Turku, Finland
P. Patterson
Affiliation:
Early Intervention Service, University of Birmingham, Birmingham, UK
M. Heinimaa
Affiliation:
Department of Psychiatry, University of Turku, 20520Turku, Finland
T. Svirskis
Affiliation:
Department of Psychiatry, University of Helsinki, Helsinki, Finland Helsinki University Central Hospital, Peijas Hospital, Vantaa, Finland
T. From
Affiliation:
Department of Psychiatry, University of Turku, 20520Turku, Finland
L. Vaskelainen
Affiliation:
Department of Psychiatry, University of Turku, 20520Turku, Finland
J. Klosterkötter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
S. Ruhrmann
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
H.G. von Reventlow
Affiliation:
LWL-Universitaetsklinik Bochum, Ruhr-Universität Bochum, Bochum, Germany
G. Juckel
Affiliation:
LWL-Universitaetsklinik Bochum, Ruhr-Universität Bochum, Bochum, Germany
D. Linszen
Affiliation:
Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
P. Dingemans
Affiliation:
Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
M. Birchwood
Affiliation:
Early Intervention Service, University of Birmingham, Birmingham, UK
*
*Corresponding author. Tel.: +358 2 3131 740; fax: +358 2 3132 730. E-mail address: Raimo.K.R.Salokangas@tyks.fi (R.K.R. Salokangas).
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Abstract

Aim

Our previous study (Salokangas et al., 2009) suggested that the subjective experience of negative attitude of others (NAO) towards oneself is an early indicator of psychotic development. The aim of this prospective follow-up study was to test this hypothesis.

Methods

A total of 55 young psychiatric outpatients assessed as being at current risk of psychosis (CROP) were followed for up to 60 months and rates of transition to psychosis (TTP) identified. CROP was assessed employing the Bonn Scale for assessment of basic symptoms (Schultze-Lutter and Klosterkötter, 2002) and the Structured Interview for prodromal symptoms (Miller et al., 2002). TTP was defined by a psychotic episode lasting for more than one week. Associations between NAO at baseline and TTP were analyzed by a Cox regression survival analysis.

Results

Eight (14.5%) TTP were identified: four (57.1%) within seven NAO patients and four (8.7%) within forty-six non-NAO patients. In the multivariate Cox regression analysis, NAO at baseline significantly (P = 0.007) predicted TTP.

Conclusion

The prospective follow-up results support our hypothesis that subjective experience of NAO is an early indicator of psychotic in development.

Keywords

Attitude of othersCurrent risk of psychosisTransition to psychosis
Type
Short communication
Information
European Psychiatry , Volume 27 , Issue 4 , May 2012 , pp. 264 - 266
Copyright
Copyright © Elsevier Masson SAS 2012

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