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Polymorphism neuropeptide receptor gene S (NPSR1) and sleep disturbances

Published online by Cambridge University Press:  23 March 2020

V. Gafarov ,
M. Voevoda ,
E. Gromova ,
V. Maximov ,
D. Panov ,
I. Gagulin  and
A. Gafarova
V. Gafarov*
Affiliation:
FSBI Institute of Internal and Preventive Medicine, Collaborative Laboratory of cardiovascular disease epidemiology, Novosibirsk, Russia
M. Voevoda
Affiliation:
FSBI Institute of Internal and Preventive Medicine, Laboratory of molecular and genetic study, Novosibirsk, Russia
E. Gromova
Affiliation:
FSBI Institute of Internal and Preventive Medicine, Collaborative Laboratory of cardiovascular disease epidemiology, Novosibirsk, Russia
V. Maximov
Affiliation:
FSBI Institute of Internal and Preventive Medicine, Laboratory of molecular and genetic study, Novosibirsk, Russia
D. Panov
Affiliation:
FSBI Institute of Internal and Preventive Medicine, Collaborative Laboratory of cardiovascular disease epidemiology, Novosibirsk, Russia
I. Gagulin
Affiliation:
FSBI Institute of Internal and Preventive Medicine, Collaborative Laboratory of cardiovascular disease epidemiology, Novosibirsk, Russia
A. Gafarova
Affiliation:
FSBI Institute of Internal and Preventive Medicine, Collaborative Laboratory of cardiovascular disease epidemiology, Novosibirsk, Russia
*
*Corresponding author.

Abstract

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Objective

To study the association gene of candidate NPSR1 rs324981 with sleep disorders in the open population of men 45–64 years of Novosibirsk.

Materials and methods

The study of the association candidate gene polymorphisms with sleep disorders was carried out during the examination of a random representative sample of men 45–69 years (n = 1770). The response rate was 61%. The median age is 56.5 year. Every 12 a man was selected for genotyping (n = 147). To assess the level of sleep was used a questionnaire which was filled with self-test. Statistical analysis was performed using SPSS-11.5.

Results

The level of sleep disorders in the male population of 45–64 years was 79.9%. The frequency of homozygous C/C genotype of neuropeptide S (gene NPSR1 rs324981) was 19.4%, T/T genotype occurs in 27.8%, C/T genotype −52.8%. Men dominated the T allele of −54.2%, and the C allele −45.8% growth trend Fnd dissatisfaction with the quality of their sleep among men. Men T-allele carriers, most evaluated their sleep as “satisfactory” in 69% of cases, (χ2 = 15,713 df = 8, P < 0.05).

Conclusion

Association found men carrier T-allele of neuropeptide S (gene NPSR1 rs324981), a sleep disorder.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW280
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S183
Copyright
Copyright © European Psychiatric Association 2016
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