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Protective Effect of Saikosaponin B2 on Damage of Cultured SH-SY5Y Cells in Vitro Introduced by Hydrogen Peroxide

Published online by Cambridge University Press:  23 March 2020

Y. Zhang ,
F. Liu ,
Z. Dai  and
Q. Wu
F. Liu
Affiliation:
xi’an mental health center, pharmacy lab, Xi’an, China
Z. Dai
Affiliation:
xi’an mental health center, pharmacy lab, Xi’an, China
Q. Wu
Affiliation:
xi’an mental health center, pharmacy lab, Xi’an, China

Abstract

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Objective

To investigate the effect of saikosaponin B2 on the damage of cultured SH-SY5Y cells.

Methods

10% calf serum including volume fraction 0.05, 0.10, 0.20 saikosaponin B2 (10−4mol·L−1) were added respectively into the SH-SY5Y cells, which were then treated with 140 μmol· L−1 hydrogen peroxide(H2O2). 10% calf serum group and blank serum without H2O2-treated group were as the model group and the control group. The effect of saikosaponin B2 was observed by morphological identification, colorimetric MTT assay.

Results

Both saikosaponin B2 of 10−6mol·L−1 and 2 × 10−6mol·L−1 can relieve the damage of SH-SY5Y cells and increase the survival of the cells.

Conclusion

saikosaponin B2 can protect the cultured SH-SY5Y cells from damage induced by H2O2.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Viewing: Others
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S707
Copyright
Copyright © European Psychiatric Association 2017
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