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Relationship between Signals Regulating Energy Homeostasis and Neuropsychological and Clinical Features in Gambling Disorder: A Case-Control Study

Published online by Cambridge University Press:  19 July 2023

F. Fernandez-Aranda ,
I. Baenas ,
M. Etxandi ,
B. Mora-Maltas ,
R. Granero ,
S. Tovar ,
C. Diéguez ,
M. N. Potenza  and
S. Jiménez-Murcia
F. Fernandez-Aranda*
Affiliation:
1Psychiatry, Bellvitge University Hospital, Barcelona 2Ciber Fisiopatología Obesidad y Nutrición, Madrid 3Psychoneurobiology of Eating and Addictive Behaviors Group, Bellvitge Institute for Biomedical Research 4Clinical Sciences, Medicine and Health Sciences School, University of Barcelona, Barcelona
I. Baenas
Affiliation:
1Psychiatry, Bellvitge University Hospital, Barcelona 2Ciber Fisiopatología Obesidad y Nutrición, Madrid 3Psychoneurobiology of Eating and Addictive Behaviors Group, Bellvitge Institute for Biomedical Research
M. Etxandi
Affiliation:
1Psychiatry, Bellvitge University Hospital, Barcelona 5Psychiatry, Hospital Universitari Germans Trias i Pujol, IGTP Campus Can Ruti, Badalona
B. Mora-Maltas
Affiliation:
1Psychiatry, Bellvitge University Hospital, Barcelona 3Psychoneurobiology of Eating and Addictive Behaviors Group, Bellvitge Institute for Biomedical Research
R. Granero
Affiliation:
2Ciber Fisiopatología Obesidad y Nutrición, Madrid 3Psychoneurobiology of Eating and Addictive Behaviors Group, Bellvitge Institute for Biomedical Research 6Psychobiology and Methodology, Autonomous University of Barcelona, Barcelona
S. Tovar
Affiliation:
2Ciber Fisiopatología Obesidad y Nutrición, Madrid 7Physiology, CIMUS, University of Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
C. Diéguez
Affiliation:
2Ciber Fisiopatología Obesidad y Nutrición, Madrid 7Physiology, CIMUS, University of Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
M. N. Potenza
Affiliation:
8Psychiatry 9Child Study Center, Yale University Medicine School 10Connecticut Mental Health Center, New Haven, CT 11Connecticut Council on Problem Gambling, Wethersfield, CT 12Neuroscience, Yale University, New Haven, CT, United States
S. Jiménez-Murcia
Affiliation:
1Psychiatry, Bellvitge University Hospital, Barcelona 2Ciber Fisiopatología Obesidad y Nutrición, Madrid 3Psychoneurobiology of Eating and Addictive Behaviors Group, Bellvitge Institute for Biomedical Research 4Clinical Sciences, Medicine and Health Sciences School, University of Barcelona, Barcelona
*
*Corresponding author.

Abstract

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Introduction

The neurobiology of gambling disorder (GD) is not yet fully understood. Although dysfunctional signalling involved in energy homeostasis has been studied in substance use disorders, it should be examined in detail in GD.

Objectives

To compare different endocrine and neuropsychological factors between individuals with GD and healthy controls (HC), and to explore endocrine interactions with neuropsychological and clinical variables.

Methods

A case-control design was performed in 297 individuals with GD and 41 HC, assessed through a semi-structured clinical interview and a psychometric battery, adding 38 HC in the evaluation of endocrine and anthropometric variables.

Results

Individuals with GD presented higher fasting plasma ghrelin (p<.001) and lower LEAP2 and adiponectin concentrations (p<.001) than HC adjusting for body mass index (BMI). The GD group reported higher cognitive impairment regarding cognitive flexibility and decision-making strategies, a worse psychological state, higher impulsivity levels, and a more dysfunctional personality profile. Despite failing to find significant associations between endocrine factors and either neuropsychological or clinical aspects in GD, some impaired cognitive dimensions and lower LEAP2 concentrations significantly predicted GD presence.

Conclusions

This study suggests distinctive neuropsychological and endocrine dysfunctions may operate in individuals with GD, predicting GD presence. Further exploration of endophenotypic vulnerability pathways in GD appear warranted, especially with respect to etiological and therapeutic potentials.

Disclosure of Interest

F. Fernandez-Aranda Consultant of: Novo Nordisk , Employee of: editorial honoraria as EIC from Wiley, I. Baenas: None Declared, M. Etxandi : None Declared, B. Mora-Maltas: None Declared, R. Granero : None Declared, S. Tovar : None Declared, C. Diéguez: None Declared, M. Potenza Grant / Research support from: Mohegan Sun Casino and Connecticut Council on Problem Gambling, Consultant of: Opiant Pharmaceuticals, Idorsia Pharmaceuticals, Baria-Tek, AXA, Game Day Data and the Addiction Policy Forum; has participated in surveys, mailings or telephone consultations related to drug addiction, impulse control disorders or other health topics; and has consulted for law offices and gambling entities on issues related to impulse control or addictive disorders, Employee of: patent application in Yale University and Novartis, S. Jiménez-Murcia: None Declared.

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S328
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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