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Remission and recovery from first-episode psychosis in adults: A systematic review and meta-analysis of long-term outcome studies

Published online by Cambridge University Press:  23 March 2020

J. Lally ,
O. Ajnakina ,
B. Stubbs ,
M. Cullinane ,
K.C. Murphy ,
F. Gaughran  and
R.M. Murray
J. Lally
Affiliation:
Royal College of Surgeons in Ireland, Department of Psychiatry, Dublin 9, Ireland Institute of Psychiatry, Psychology and Neuroscience, King's College London, Department of Psychosis Studies, London, United Kingdom
O. Ajnakina
Affiliation:
Institute of Psychiatry, Psychology and Neuroscience, King's College London, Department of Psychosis Studies, London, United Kingdom
B. Stubbs
Affiliation:
Institute of Psychiatry, Psychology and Neuroscience IoPPN, King's College London, Health Service and Population Research Department, London, United Kingdom
M. Cullinane
Affiliation:
Young Adult Mental Health Services, St. Fintan's Hospital, Portlaoise, Ireland
K.C. Murphy
Affiliation:
Royal College of Surgeons in Ireland, Department of Psychiatry, Dublin 9, Ireland
F. Gaughran
Affiliation:
Institute of Psychiatry, Psychology and Neuroscience, King's College London, Department of Psychosis Studies, London, United Kingdom
R.M. Murray
Affiliation:
Institute of Psychiatry, Psychology and Neuroscience, King's College London, Department of Psychosis Studies, London, United Kingdom

Abstract

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Introduction

Remission and recovery rates for people who have had a first episode psychosis (FEP) remain uncertain.

Objectives

We conducted a systematic review and meta-analysis to assess pooled prevalence rates of remission and recovery in FEP in longitudinal studies and conducted meta regression analyses to investigate potential moderators.

Methods

A systematic literature search of major electronic databases without language restrictions was conducted from database inception until July 1, 2016. Longitudinal studies with follow up greater than 1 year reporting data on remission or recovery rates in FEP were included.

Results

Seventy-nine studies were included representing 19,072 FEP patients (mean age = 26.9 years, male = 59.5%). The pooled rate of remission among 12,301 individuals with FEP was 57.9% (95%CI: 52.7–62.9, Q = 1536.3, P< 0.001, n = 60 studies, mean follow up = 5.5 years). Restricting the analysis to studies, which used the remission in schizophrenia working group (RSWG) criteria (n = 25 studies, n = 6909 patients), the pooled remission rate was 56.9% (95%CI: 48.9–64.5, Q = 656.9). Higher remission rates were moderated by studies from more recent years. The pooled prevalence of recovery among 9642 individuals with FEP was 37.9% (95%CI: 30.0–46.5, Q = 1450.8, studies = 35, P = 0.006, average follow up = 7.2 years). Recovery rates were higher (P< 0.05) in North America compared to other regions.

Conclusions

Our data suggest that remission and recovery rates in FEP may be more favorable than previously thought. We observed stability of recovery rates after the first two years, suggesting that a progressive deteriorating course of illness is not typical. While remission rates have improved over time, recovery rates have not, raising questions about the effectiveness of specialist early intervention services in achieving improved recovery.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Viewing: Schizophrenia and other psychotic disorders
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. s819
Copyright
Copyright © European Psychiatric Association 2017
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