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Results of the German Research Network on Schizophrenia: Early intervention in the initial prodromal phase

Published online by Cambridge University Press:  16 April 2020

J. Klosterkoetter ,
A. Bechdolf  and
S. Ruhrmann
J. Klosterkoetter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
A. Bechdolf
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
S. Ruhrmann
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

Abstract

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Background and Aims

To determine whether a differential state specific intervention in the initial prodromal state is effective for preventing progression to psychosis.

Method

128 patients in the early initial prodromal state (EIPS) were randomized to receive either a comprehensive cognitive behavior therapy (CBT) intervention or supportive counseling (SC) for 12 months. 124 patients in a putatively late initial prodromal state (LIPS) were randomly assigned to a needs-focused inter-vention (NFI) or to NFI plus amisulpride.

Results

In the EIPS trial Kaplan-Meier estimates of the risks of transitions to LIPS (5.3% vs. 18.5%, p=0.032), psychosis (1.6% vs. 13.8%, p=0.020) and schizophrenia (none vs. 13.8%, p=0.005) at month 12 were statistically significant lower in the CBT group than in the SC group. In the LIPS trial Amisul-pride+NFI produced superior effects to NFI alone on attenuated and full-blown psychotic symptoms, basic, depressive and negative symptoms and global functioning at week 12.

Conclusion

First results indicate that a differential intervention to the initial prodromal state is effective for preventing progression to psychosis.

Type
S47. Symposium: Prodrome-Based Early Intervention in the Course of Schizophrenia
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S76
Copyright
Copyright © European Psychiatric Association 2007
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