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S13.01 - Coupling repetitive TMS with functional MRI for the treatment of drug-resistant hallucinations in children with early onset schizophrenia

Published online by Cambridge University Press:  16 April 2020

R. Jardri
Affiliation:
LNFP, CNRS-UMR-8160, Universite Lille 2, CHRU de Lille, Lille, France Service de Psychiatrie Infanto-Juvenile, Hopital Fontan, CHRU de Lille, Lille, France
Y. Delevoye-Turrell
Affiliation:
Laboratoire URECA, Departement de Psychologie, Universite Lille 3, Villeneuve D'Ascq, France
B. Lucas
Affiliation:
Service de Psychiatrie Adulte, Hopital Fontan, CHRU de Lille, Lille, France
D. Pins
Affiliation:
LNFP, CNRS-UMR-8160, Universite Lille 2, CHRU de Lille, Lille, France
P. Thomas
Affiliation:
LNFP, CNRS-UMR-8160, Universite Lille 2, CHRU de Lille, Lille, France Service de Psychiatrie Adulte, Hopital Fontan, CHRU de Lille, Lille, France
P. Delion
Affiliation:
Service de Psychiatrie Infanto-Juvenile, Hopital Fontan, CHRU de Lille, Lille, France
J.L. Goeb
Affiliation:
LNFP, CNRS-UMR-8160, Universite Lille 2, CHRU de Lille, Lille, France Service de Psychiatrie Infanto-Juvenile, Hopital Fontan, CHRU de Lille, Lille, France

Abstract

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To date, there is an absence of curative treatment for very early onset schizophrenia. The antipsychotic drugs that are currently recommended have very little effect and are often badly tolerated by children. We report a case-study which results show a beneficial and significant efficacy of fMRI-guided rTMS in the treatment of pharmaco-resistant hallucinations. Moreover, rTMS applied over several cortical regions provided the means to reveal for the first time a functional dissociation between auditory-verbal hallucinations and agency impairments. These results demonstrate the efficacy of rTMS for young patients suffering from drug-resistant hallucinations but they furthermore question the physiopathology of the hallucinatory process by suggesting that agency and hallucinations may be sub served by different neural networks.

Type
Symposium: Hallucination in children and adolescents: Risk factors and treatment strategies
Copyright
Copyright © European Psychiatric Association 2008
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