The evaluation of safety represents the our interest, especially with references to older people that receive at the same time many drugs for psychiatric disorders and physical diseases. The polypharmacy between older people is a frequent phenomenon but little is know about adverse effects of antidepressants.

We have examined the prescriptions in 10 nursing homes to collect adverse effects, included cause mortality, during a follow up of 2 years.

The incidence of adverse events with Trazodone is very low, as so compared to other antidepressants. Also, older people, are a special population with high comorbidity. Still it is very difficult to reduce the recurrence to polypharmacy in these field but we must become integrated with general practitioners and other specialists.