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Severity of Affective Symptoms Associated to Sicam-1 and Svcam-1 Serum Levels in Bipolar Mania

Published online by Cambridge University Press:  15 April 2020

M. Pantovic ,
N. Petronijevic ,
B. Dunjic-Kostic ,
M. Velimirovic ,
T. Nikolic ,
M. Lackovic ,
A. Damjanovic ,
S. Totic-Poznanovic ,
A. Jovanovic  and
M. Ivkovic
M. Pantovic
Affiliation:
Affective disorders, Clinic for Psychiatry Clinical Centre of Serbia, Belgrade, Serbia
N. Petronijevic
Affiliation:
Neurobiochemistry, Institute of Clinical and Medical Biochemistry and School of Medicine University of Belgrade Belgrade Serbia, Belgrade, Serbia
B. Dunjic-Kostic
Affiliation:
Affective disorders, Clinic of Psychiatry Clinical Centre of Serbia Belgrade Serbia, Belgrade, Serbia
M. Velimirovic
Affiliation:
Neurobiochemistry, Institute of Clinical and Medical Biochemistry and School of Medicine University of Belgrade Belgrade Serbia, Belgrade, Serbia
T. Nikolic
Affiliation:
Neurobiochemistry, Institute of Clinical and Medical Biochemistry and School of Medicine University of Belgrade Belgrade Serbia, Belgrade, Serbia
M. Lackovic
Affiliation:
Affective disorders, Clinic for Psychiatry Clinical Centre of Serbia, Belgrade, Serbia
A. Damjanovic
Affiliation:
Affective disorders, Clinic for Psychiatry Clinical Centre of Serbia, Belgrade, Serbia
S. Totic-Poznanovic
Affiliation:
Affective disorders, Clinic for Psychiatry Clinical Centre of Serbia, Belgrade, Serbia
A. Jovanovic
Affiliation:
Affective disorders, Clinic for Psychiatry Clinical Centre of Serbia, Belgrade, Serbia
M. Ivkovic
Affiliation:
Affective disorders, Clinic for Psychiatry Clinical Centre of Serbia, Belgrade, Serbia

Abstract

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Introduction

Immune alterations are considered an important factor in etiopathogenesis of bipolar disorder.

Aims

The aim of the study has been to assess the relation between soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular cell adhesion molecule-1 (sICAM-1), in acute and remission phase of mania, in regard to severity of depressive and manic symptoms.

Methods

The study has explored serum levels of sVCAM-1 and sICAM-1 in 40 patients with mania. The adhesion molecules' levels of patient group have been analyzed in acute and remission phases, in regard to severity of depressive sympotoms (measured by Hamilton Depression Scale) and in regard to severity of manic symptoms (measured by Young Mania Rating Scale).

Results

The acute serum levels of sVCAM-1 have been inversily associated to YMRS score and directly associated to HAMD score, in acute phase. Serum levels of sICAM-1 have shown no association to severity of affective symptoms, in both phases of the disorder.

Conclusions

Our results suggest that cellular adhesion acute could be one of the factors mediating affective symptoms presentation in bipolar mania.

Type
Article: 0461
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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