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Systemic endotoxinemia as a probable factor in reducing the treatment effectiveness of endogenous psychosis

Published online by Cambridge University Press:  13 August 2021

S. Zozulya ,
I. Otman ,
I. Oleichik ,
I. Anikhovskaya ,
M. Yakovlev  and
T. Klyushnik
S. Zozulya*
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
I. Otman
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
I. Oleichik
Affiliation:
Clinical Department Of Endogenous Mental Disorders And Affective States, Mental Health Research Centre, Moscow, Russian Federation
I. Anikhovskaya
Affiliation:
Laboratory Of Systemic Endotoxinemia And Shock, Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
M. Yakovlev
Affiliation:
Laboratory Of Systemic Endotoxinemia And Shock, Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
T. Klyushnik
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Inflammation is an important factor in the pathogenesis of endogenous psychosis. An inducer of inflammatory reactions can be endotoxin aggression of intestinal origin.

Objectives

To determine the level of inflammation markers and indicators of systemic endotoxinemia in blood of patients with endogenous psychosis in relation to assessment of the treatment effectiveness.

Methods

25 patients with endogenous psychosis (F20, F25) were examined before and after treatment. The control group consisted of 25 healthy people. The activity of inflammatory markers - leukocyte elastase, α1-antitrypsin, antibodies to S-100B, and indicators of systemic endotoxinemia – endotoxin concentration and antiendotoxin immunity activity were measured in blood serum. The treatment effectiveness was assessed by the dynamics of inflammatory markers.

Results

Based on the results of determining the studied parameters before treatment, all patients were divided into two groups. In the 1st group (6 patients, 24%), an increase of inflammatory markers activity and high concentration of endotoxin in the blood serum were revealed (p<0,001, p<0,05, respectively). In the 2nd group (19 patients, 76%), only activation of inflammatory reactions (p<0,001) was detected. After therapy in the 1st group of patients, there was no positive dynamics of all studied markers, which indicated an active course of the pathological process. In the 2nd group, the normalization of inflammatory markers was shown (p<0,05), which corresponded to the formation of remission.

Conclusions

The results indicate that endotoxic aggression contributes to reduction of the effectiveness of endogenous psychosis therapy and can be considered as an additional therapeutic target.

Keywords

endogenous psychosisinflammatory markerstreatment effectivenesssystemic endotoxemia
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S472
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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