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White matter abnormalities in obsessive-compulsive disorder: A diffusion tensor imaging study

Published online by Cambridge University Press:  16 April 2020

Y. Saito ,
K. Nobuhara ,
G. Okugawa ,
K. Takase ,
A. Tajika ,
T. Sugimoto ,
H. Kurokawa ,
K. Ikeda ,
S. Sawada  and
T. Kinoshita
Y. Saito
Affiliation:
Department of Neuropsychiatry, Kansai Medical University, Takii Hospital, Moriguchi City, Osaka, Japan
K. Nobuhara
Affiliation:
Department of Neuropsychiatry, Kansai Medical University, Takii Hospital, Moriguchi City, Osaka, Japan
G. Okugawa
Affiliation:
Department of Neuropsychiatry, Kansai Medical University, Takii Hospital, Moriguchi City, Osaka, Japan
K. Takase
Affiliation:
Department of Neuropsychiatry, Kansai Medical University, Takii Hospital, Moriguchi City, Osaka, Japan
A. Tajika
Affiliation:
Department of Neuropsychiatry, Kansai Medical University, Takii Hospital, Moriguchi City, Osaka, Japan
T. Sugimoto
Affiliation:
Department of Neuropsychiatry, Kansai Medical University, Takii Hospital, Moriguchi City, Osaka, Japan
H. Kurokawa
Affiliation:
Department of Radiology, Kansai Medical University, Hirakata Hospital, Hirakata City, Osaka, Japan
K. Ikeda
Affiliation:
Department of Radiology, Kansai Medical University, Hirakata Hospital, Hirakata City, Osaka, Japan
S. Sawada
Affiliation:
Department of Radiology, Kansai Medical University, Hirakata Hospital, Hirakata City, Osaka, Japan
T. Kinoshita
Affiliation:
Department of Neuropsychiatry, Kansai Medical University, Takii Hospital, Moriguchi City, Osaka, Japan

Abstract

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Background and aims:

The subdivisions of the corpus callosum (CC) were attempted to define corresponding areas of the cortex from which the fibers originate. Previous neuroanatomic studies of the CC provide impetus for investigating its role in obsessive-compulsive disorder (OCD).

Methods:

In this study diffusion tensor imaging (DTI) was employed to microstructural abnormalities of white matter of the CC in OCD patients. Nine patients with OCD and matched control subjects underwent DTI. Fractional anisotropy (FA), an index of the integrity of white matter tracts, was determined in the seven subdivisions of the CC. We placed each reagions of interest (ROI) over the sagittal plane and all subdivisions were measured.

Results:

Significant reduction in FA was found in the rostrum of the CC of patients with OCD compared with one of controls. FA of the other subdivisions except the rostrum in OCD patients did not differ significantly compared with control subjects. Higher FA in the rostrum correlated significantly with lower Y-BOCS scores (r = -0.803, p = 0.009).

Conclusions:

The rostrum contains fibers from inferior premotor as well as medial and caudate/orbital prefrontal regions. These results supported the theory of dysfunction of prefrontal cortex and striatal circuits in OCD and suggested the implication of the orbitofrontal circuit for symptom severity in the OCD patients.

Type
Poster Session 2: Obsessive-Compulsive Disorders
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S294
Copyright
Copyright © European Psychiatric Association 2007
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