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OBSTETRIC CHOLESTASIS

Part of: Bespoke shallow archive Weizmann

Published online by Cambridge University Press:  01 May 2009

ANNA P KENYON  and
ANDREW SHENNAN
ANNA P KENYON*
Affiliation:
Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, School of Biomedical and Health Sciences, Kings College London, London.
ANDREW SHENNAN
Affiliation:
Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, School of Biomedical and Health Sciences, Kings College London, London.
*
Anna P Kenyon, Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, School of Biomedical and Health Sciences, Kings College London, 10th Floor North Wing, St Thomas' Hospital Campus, Westminster Bridge Road London SE1 7EH, United Kingdom.
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Extract

Obstetric cholestasis (OC) also known a intrahepatic cholestatsis of pregnancy (ICP) is defined as pruritus of onset in pregnancy in association with abnormal liver function in the absence of any other identifiable liver pathology which resolves on delivery. It may be associated with adverse obstetric outcome and significant maternal morbidity. In the UK the prevalence is thought to be 0.6–0.7%, with up to 39–41% of women with OC being of Indian or Pakistani origin. Higher prevalence is also observed in Scandinavia (2%) and Chile (4%), (especially women of Araucanian Indian descent 24%). The condition occurs more commonly amongst twin pregnancies (20–22%) and is more common in the winter months in both Scandinavian and Chilean populations. The condition may occur more frequently in those >35 years of age (25% of cases).

Type
Research Article
Information
Fetal and Maternal Medicine Review , Volume 20 , Issue 2 , May 2009 , pp. 119 - 142
Copyright
Copyright © Cambridge University Press 2009

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