Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-29T16:44:36.540Z Has data issue: false hasContentIssue false
  • English
  • Français

Anomalously revertible rII mutants of phage T4

Published online by Cambridge University Press:  14 April 2009

R. Freedman  and
S. Brenner
R. Freedman
Affiliation:
Medical Research Council Unit for Molecular Biology, Hills Road, Cambridge, England
S. Brenner
Affiliation:
Medical Research Council Unit for Molecular Biology, Hills Road, Cambridge, England
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A class of rII mutants revertible by both base analogues and acridines is described. The members of this anomalous class are base-substitution mutants suppressed by a phase-shift mutation in a phage gene mapping outside the rII region.

Type
Research Article
Information
Genetics Research , Volume 19 , Issue 2 , April 1972 , pp. 165 - 171
Copyright
Copyright © Cambridge University Press 1972

References

REFERENCES

Barnett, L., Brenner, S., Crick, F. H. C., Shulman, R. G. & Watts-Tobin, R. J. (1967). Phase-shift and other mutants in the first part of the rIIB cistron of bacteriophage T4. Philosophical Transactions of the Royal Society of London B 252, 487–560.Google Scholar
Benzer, S. & Champe, S. P. (1961). Ambivalent rII mutants of phage T4. Proceedings of National Academy of Sciences of the U.S.A. 47, 1025–1038.CrossRefGoogle ScholarPubMed
Brenner, S., Barnett, L., Crick, F. H. C. & Orgel, A. (1961). The theory of mutagenesis. Journal of Molecular Biology 3, 121–124.CrossRefGoogle Scholar
Brenner, S. & Beckwith, J. R. (1965). Ochre mutants, a new class of suppressible nonsense mutants. Journal of Molecular Biology 13, 629–637.CrossRefGoogle Scholar
Champe, S. P. & Benzer, S. (1962). Reversal of mutant phenotypes by 5-Fluoruraeil: an approach to nucleotide sequences in messenger-R.N.A. Proceedings of National Academy of Sciences of the U.S.A. 48, 532–546.CrossRefGoogle Scholar
Edgar, B. S. & Epstein, R. H. (1961). Inactivation by ultraviolet light of an acriflavine-sensitive gene function in phage T4D. Science 134, 327–328.CrossRefGoogle ScholarPubMed
Edgar, R. S. & Wood, W. B. (1966). Morphogenesis of bacteriophage T2 in extracts of mutant-infected cells. Proceedings of National Academy of Sciences of the U.S.A. 55, 498–505.CrossRefGoogle ScholarPubMed
Epstein, R. H., Bolle, A., Steinberg, C. M., Kellenberger, E., Boy De La Tour, E., Chevalley, R., Edgar, R. S., Susman, M., Denhardt, G. H. & Lielausis, A. (1963). Physiological studies of conditional lethal mutants of bacteriophage T4D. Cold Spring Harbor Symposia on Quantitative Biology 28, 375–394.CrossRefGoogle Scholar
Freedman, R. & Brenner, S. (1972). Hybrid T4 rII B cistrons created by genetic duplications. Journal of Molecular Biology. (In press.)CrossRefGoogle Scholar
Joslin, R. (1970). The lysis mechanism of phage T4: mutants affecting lysis. Virology 40, 719–726.CrossRefGoogle Scholar
Joslin, R. (1971). Physiological studies on the t gene defect in T4-infected Escherichia coli. Virology 44, 101–107.CrossRefGoogle Scholar
Krieg, D. R. (1963). Specificity of chemical mutagenesis. Progress in Nucleic Acid Research 2, 125–168.CrossRefGoogle Scholar
McClain, W. H. & Champe, S. P. (1967). Detection of a peptide determined by the rIIB cistron of phage T4. Proceedings of National Academy of Sciences of the U.S.A. 58, 1182–1888.CrossRefGoogle Scholar
Orgel, A. & Brenner, S. (1961). Mutagenesis of bacteriophage T4 by acridines. Journal of Molecular Biology 3, 762–768.CrossRefGoogle ScholarPubMed
Sarabhai, A. & Brenner, S. (1967). A mutant which reinitiates the polypeptide chain after chain termination. Journal of Molecular Biology 27, 145–162.CrossRefGoogle ScholarPubMed