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Close linkage between genes which cause hairlessness in the mouse

Published online by Cambridge University Press:  14 April 2009

S. P. Flanagan  and
J. H. Isaacson
S. P. Flanagan
Affiliation:
Institute of Animal Genetics, Edinburgh 9
J. H. Isaacson
Affiliation:
Institute of Animal Genetics, Edinburgh 9
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1. A new semi-dominant gene called shaven (Sha) causes hairlessness in the mouse and it is closely linked to naked. Homozygous shaven mice never grow a first coat and adults grow a few short hairs only. Shaven heterozygotes grow a full coat which is greasy.

2. The percentage recombination between shaven and naked was found to be 0·8%. Three-point tests with naked and caracul showed that the order of the three loci is either N–Sha–Ca or N–Ca–Sha.

3. The failure of homozygous shaven mice to grow a coat is due to abnormal keratinization of the hairs in the follicles. The follicles were found to be deficient in sulphydryl groups.

4. The greasiness of the Sha+ coat is due to the presence of a sudanophilic fluid in the hair medullae.

5. The close linkage between the two genes with similar phenotypic effects is discussed.

Type
Research Article
Information
Genetics Research , Volume 9 , Issue 1 , February 1967 , pp. 99 - 110
Copyright
Copyright © Cambridge University Press 1967

References

REFERENCES

Bennett, H. S. (1951). The demonstration of thiol groups in certain tissues by means of a new coloured sulphydryl reagent. Anal. Rec. 110, 231.CrossRefGoogle Scholar
Bern, H. A., Harkness, D. R. & Blair, S. M. (1955). Radioautographic studies of keratin formation. Proc. natn. Acad. Sci. U.S.A. 41, 55–60.CrossRefGoogle ScholarPubMed
Carter, T. C. & Falconer, D. S. (1951). Stocks for detecting linkage in the mouse and the theory of their design. J. Genet. 50, 307–323.CrossRefGoogle ScholarPubMed
David, L. T. (1932). The external expression and comparative dermal histology of hereditary hairlessness in mammals. Z. Zellforsch. mikrosk. Anat. 14, 616–719.CrossRefGoogle Scholar
Dunn, L. C. & Caspari, E. (1942). Close linkage between mutations with similar effects. Proc. natn. Acad. Sci. U.S.A. 28, 205–210.CrossRefGoogle ScholarPubMed
Falconer, D. S., Fraser, A. S. & King, J. W. B. (1951). The genetics and development of crinkled, a new mutant in the house mouse. J. Genet. 50, 324–344.CrossRefGoogle ScholarPubMed
Falconer, D. S. & Snell, G. D. (1952). Two new hair mutants, rough and frizzy, in the house mouse. J. Hered. 43, 53–57.CrossRefGoogle Scholar
Fisher, R. A. & Yates, F. (1948). Statistical Table for Biological, Agrciultural and Medical Research, 3rd ed.London and Edinburgh: Oliver & Boyd.Google Scholar
Flanagan, S. P. (1966). ‘Nude’, a new hairless gene with pleiotropic effects in the mouse. Genet. Res. 8, 153–167.CrossRefGoogle ScholarPubMed
Fraser, F. C. (1946). The expression and interaction of factors producing hypotrichosis in the house mouse: histology and experimental results. Can. J. Res. D, 24, 10–25.CrossRefGoogle ScholarPubMed
Grüneberg, H. & Truslove, G. M. (1960). Two closely linked genes in the mouse. Genet. Res. 1, 69–90.CrossRefGoogle Scholar
Herbertson, B. M., Skinner, M. E. & Tatchell, J. A. H. (1959). ‘Sticky’, a new mutant in the guinea pig. J. Genet. 56, 315–324.CrossRefGoogle Scholar
Mallyon, S. A. (1951). A pronounced sex difference in recombination values in the sixth chromosome of the house mouse. Nature, Lond. 168, 118–119.CrossRefGoogle ScholarPubMed
Murray, J. M. & Snell, G. D. (1945). Belted, a new sixth chromosome mutation in the mouse. J. Hered. 36, 266–268.CrossRefGoogle Scholar
Ryder, M. L. (1958). Investigations into the distribution of thiol groups in the skin follicles of mice and sheep and the entry of labelled sulphur compounds. Proc. R. Soc. Edinb. (B), LXVII (1), 65.Google Scholar