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Fixation probability of a mutant influenced by random fluctuation of selection intensity*

Published online by Cambridge University Press:  14 April 2009

Tomoko Ohta
Tomoko Ohta
Affiliation:
National Institute of Genetics, Mishima, Japan
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Summary

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The probability of fixation of a mutant gene in a finite population was investigated by taking into account the effect of random fluctuation of selection intensity. It was shown that not only the product of the effective population number and average selection coefficient (Nes) is important, but also the ratio of the mean and the variance of selection coefficient (s/ Vs) has an important influence on fixation probability. In particular, when this ratio is small, a mutant gene, even if selected against, becomes fixed in the population like a selectively neutral mutant. In general, when random fluctuation of selection intensity is not negligible it may be convenient to use ‘effective selection coefficient’. The bearing of the present findings on the neutral mutation-random drift theory of evolution and variation at the molecular level was discussed.

Type
Research Article
Information
Genetics Research , Volume 19 , Issue 1 , February 1972 , pp. 33 - 38
Copyright
Copyright © Cambridge University Press 1972

References

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