Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-28T02:54:41.457Z Has data issue: false hasContentIssue false
  • English
  • Français

Genetical control of the anaphylactoid reaction in rats

Published online by Cambridge University Press:  14 April 2009

J. M. Harris ,
H. Kalmus  and
G. B. West
J. M. Harris
Affiliation:
Department of Pharmacology, School of Pharmacy, Brighton College of Technology
H. Kalmus
Affiliation:
Galton Laboratory, University College, London
G. B. West
Affiliation:
Department of Pharmacology, School of Pharmacy, University of London
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. A recessive autosomal gene, dx, preventing the anaphylactoid reaction has been discovered in a stock of Wistar albino rats from the Agricultural Research Council, Compton.

2. Segregation occurred in the F2 generation derived from crossing pure-bred reactor rats and pure-bred non-reactor rats.

3. Non-reactivity was outbred into non-albino stocks and was shown to segregate independently of the albino gene c and not to be closely linked to the colour genes, P and A.

4. The mutation from Dx to dx may have arisen a few years ago in one of the Wistar colonies before it was split into sub-lines.

5. The dx gene is fixed in several brother-sister mated sub-lines and appears to be in equilibrium with Dx in some less inbred closed-populations.

Type
Research Article
Information
Genetics Research , Volume 4 , Issue 3 , November 1963 , pp. 346 - 355
Copyright
Copyright © Cambridge University Press 1963

References

REFERENCES

Deol, M. S. (1963). In: Breeding and Management of Some Common Laboratory Animals, edited by Lane-Petter, W.. London: Academic Press (in preparation).Google Scholar
Deol, M. S., Grüneberg, H., Searle, A. G. & Truslove, G. M. (1960). How pure are our inbred strains of mice? Genet. Res. 1, 50–58.CrossRefGoogle Scholar
Grewal, M. S. (1962). The rate of genetic divergence of sublines in the C57BL strain of mice. Genet. Res. 3, 226–237.CrossRefGoogle Scholar
Harris, J. M. & West, G. B. (1961). Anaphylaetoid reaction in rats. Nature, Lond., 191, 399–400.CrossRefGoogle ScholarPubMed
Harris, J. M. & West, G. B. (1963). Rats resistant to the dextran anaphylactoid reaction. Brit. J. Pharmacol. 20, 550–562.Google Scholar
Kalow, W. (1962). Pharmacogenetics. Heredity and the Response to Drugs. Philadelphia: W. B. Saunders Company.Google Scholar
Kátó, L. & Gözsy, B. (1960 a). Effect of phenothiazine derivatives on dextran-induced edema. J. Pharmacol. 129, 231–236.Google ScholarPubMed
Kátó, L. & Gözsy, B. (1960 b). Kinetics of edema formation in rats as influenced by critical doses of dextran. Amer. J. Physiol. 199, 657–660.CrossRefGoogle ScholarPubMed
Léger, J., Masson, G. & Prado, J. Leal. (1947). Hypersensitivity to egg-white in the rat. Proc. Soc. exp. Biol., N.Y., 64, 366–370.CrossRefGoogle ScholarPubMed
Léger, J. & Masson, G. M. C. (1948). Studies on eggwhite sensitivity in the rat. Ann. Allergy, 6, 131–143.Google ScholarPubMed
Levy, S. W. & Vaillancourt, De Guise (1960). Effects of inflammation on proteins and enzymes in rat plasma. Canad. J. Biochem. 38, 575–584.Google Scholar
Little, C. C. (1958). Coat colour genes in rodents and carnivores. Quart. Rev. Biol. 33, 103–137.Google Scholar
Morrison, J. L., Bloom, W. L. & Richardson, A. P. (1951 a). Effect of dextran on the rat. J. Pharmacol. 101, 27–28.Google Scholar
Morrison, J. L., Richardson, A. P. & Bloom, W. L. (1951 b), Effect of antihistaminic agents on the reaction of the rat to dextran. Arch. int. Pharmacodyn. 88, 98–105.Google Scholar
Selye, H. (1937). Studies on adaptation. Endocrinology, 21, 169–188.Google Scholar
Voorhees, A. B., Baker, H. J. & Pulaski, E. J. (1951). Reactions of albino rats to injections of dextran. Proc. Soc. exp. Biol., N.Y., 76, 254–256.Google Scholar