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The liver/erythrocyte pyruvate kinase gene complex [Pk-1] in the mouse: structural gene mutations

Published online by Cambridge University Press:  14 April 2009

Lesley A. Fitton  and
Grahame Bulfield
Lesley A. Fitton
Affiliation:
Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian EH25 9PS, U.K.
Grahame Bulfield*
Affiliation:
Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian EH25 9PS, U.K.
*
†Corresponding author.

Summary

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Nine enzyme activity variants of liver/erythrocyte pyruvate kinase have been found amongst laboratory and wild mice. Four of these variants have been shown by biochemical and immunological criteria to be mutations of the structural gene, Pk-1s. These four structural gene mutations, and two regulatory gene mutations, define the gene complex, [Pk-1]. One allele of the structural gene, Pk-1sl, found in the inbred strain C57BL, has an unusual phenotype and affects the expression of pyruvate kinase in the liver but not erythrocyte. A possible mechanism for this tissue-specific structural gene mutation is suggested.

Type
Research Article
Information
Genetics Research , Volume 53 , Issue 2 , April 1989 , pp. 105 - 110
Copyright
Copyright © Cambridge University Press 1989

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