Hostname: page-component-77c89778f8-n9wrp Total loading time: 0 Render date: 2024-07-16T10:31:35.903Z Has data issue: false hasContentIssue false
  • English
  • Français

Mechanism of infertility in t-complex mice

Published online by Cambridge University Press:  14 April 2009

J. R. Archer ,
S. J. Self  and
B. G. Winchester
J. R. Archer
Affiliation:
Searle Research Laboratories, High Wycombe, Bucks
S. J. Self
Affiliation:
Department of Biochemistry, Queen Elizabeth College, London
B. G. Winchester
Affiliation:
Department of Biochemistry, Queen Elizabeth College, London

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Sperm from mice heterozygous (t/+) for many t-lethal haplotypes show segregation distortion. More offspring inherit the t-haplotype than the normal wild haplotype. In contrast males heterozygous (tx/tv) for two t-lethal haplotypes are sterile although they produce normal-looking sperm. The experiments were undertaken to show whether sperm from tx/tv mice are the same as t-fertile sperm from t/+. Female albino mice were persuaded to mate first with coloured sterile tx/tv heterozygotes and then with normal white +/+ males. With the exception of one litter (from a t-heterozygous male which proved to have been misidentified) all the progeny were derived from the mating with the normal father. We conclude that t-bearing sperm from t-lethal (tx/tv) heterozygotes are inviable, and different from t-sperm in t/+ heterozygotes.

Type
Research Article
Information
Genetics Research , Volume 32 , Issue 1 , August 1978 , pp. 79 - 84
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

Bennett, D. & Dunn, L. C. (1971). Transmission ratio distorting genes on chromosome IX and their interactions. Proc. Symp. Immunogenetics of the H-2 system, pp. 90–103. Karger-Basel.Google Scholar
Bennett, D. (1975). The T-locus of the mouse. Cell 6, 441–454.CrossRefGoogle Scholar
Bryson, V. (1944). Spermatogenesis and fertility in Mus musculus as affected by factors at the T-locus. Journal of Morphology 74, 131–179.CrossRefGoogle Scholar
Fowler, R. E. & Edwards, R. G. (1957). Induction of superovulation and pregnancy in mature mice by gonadotropins. Journal of Endocrinology 15, 374–384.CrossRefGoogle Scholar
Gluecksohn-Waelsch, S. & Erickson, R. P. (1970). The T-locus of the mouse: implications for mechanisms of development. Current Topics in Developmental Biology 5, 281–316.CrossRefGoogle ScholarPubMed
Hammerberg, C., Klein, J., Artzt, K. & Bennett, D. (1976). Histocompatilility-2 system in wild mice. II. H-2 haplotypes of t-bearing mice. Transplantation 21, 199–212.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Mason, I. (1977). Information on the nature of t-haplotypes from the interaction of mutant haplotypes in male fertility and segretation ratio. Genetical Research 29, 255–266.CrossRefGoogle Scholar
Lyon, M. F. & Phillips, R. J. (1959). Crossing-over in mice heterozygous for t-alleles. Heredity 13, 23–32.CrossRefGoogle Scholar
Olds, P. J. (1970). Effect of the T-locus on sperm distribution in the house mouse. Biology of Reproduction 2, 91–97.CrossRefGoogle ScholarPubMed
Olds, P. J. (1971 a). Effect of the T-locus on fertilization in the house mouse. Journal of Experimental Zoology 177, 417–434.CrossRefGoogle ScholarPubMed
Olds, P. J. (1971 b). Effect of the T-locus on sperm ultrastructure in the house mouse. Journal of Anatomy 109, 31–37.Google ScholarPubMed
Sanderson, A. R. (1965). Quantitative titration, kinetic behaviour and inhibition of cytotoxic mouse isoantisera. Immunology 9, 287–300.Google ScholarPubMed
Sharma, O. P. & Hays, R. L. (1975). Heterospermic insemination and its effect on the off-spring ratio in rats. Journal of Reproduction and Fertility 45, 533–535.CrossRefGoogle Scholar
Staats, J. (1976). Standardized nomenclature for inbred strains of mice: sixth listing. Cancer Research 36, 4333–4377.Google ScholarPubMed
Wigzell, H. (1965). Quantitative titrations of mouse H-2 antibodies using Cr51 labelled target cells. Transplantation 3, 423–431.CrossRefGoogle Scholar