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Paternal inheritance of egg traits in mice: a case of genomic imprinting

Published online by Cambridge University Press:  14 April 2009

S. A. A. Bander ,
S. C. Watson  and
J. G. M. Shire
S. A. A. Bander
Affiliation:
Department of Biology, University of Essex, Colchester, C04 3SQ
S. C. Watson
Affiliation:
Department of Biology, University of Essex, Colchester, C04 3SQ
J. G. M. Shire*
Affiliation:
Department of Biology, University of Essex, Colchester, C04 3SQ
*
* Corresponding author.

Summary

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Eggs from reciprocal hybrids between the C57BL/6By and BALB/cBy strains were tested for their susceptibility to attack by hyaluronidase and pronase. There were significant reciprocal differences between the F1 females in the responses of their unfertilized eggs to both enzymes. The F1 hybrids from BALB mothers showed the increased susceptibility characteristic of C57BL whilst the F1 hybrids with C57BL mothers were more resistant to both enzymes, like BALB mice. Eggs from the four kinds of reciprocal F2 hybrid females also showed patroclinous patterns of susceptibility. A patroclinous difference was found between reciprocal crosses of the CXBD and CXBE recombinant inbred strains but not in crosses between recombinant inbred strains with similar phenotypes. Cross fostering did not alter the phenotypes of the C57BL and BALB females or those of their reciprocal F1 hybrids. The findings are interpreted in terms of differential genomic imprinting of paternally inherited information. The possible general usefulness of patroclinous differences between reciprocal F1 females in revealing differences in imprinting is noted.

Type
Research Article
Information
Genetics Research , Volume 54 , Issue 3 , December 1989 , pp. 213 - 219
Copyright
Copyright © Cambridge University Press 1989

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