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Speed congenics: accelerated genome recovery using genetic markers

Published online by Cambridge University Press:  01 August 1999

P. M. VISSCHER
P. M. VISSCHER
Affiliation:
Institute of Ecology and Resource Management, University of Edinburgh, Edinburgh EH9 3JG, Scotland, UK

Abstract

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Genetic markers throughout the genome can be used to speed up ‘recovery’ of the recipient genome in the backcrossing phase of the construction of a congenic strain. The prediction of the genomic proportion during backcrossing depends on the assumptions regarding the distribution of chromosome segments, the population structure, the marker spacing and the selection strategy. In this study simulation was used to investigate the rate of recovery of the recipient genome for a mouse, Drosophila and Arabidopsis genome. It was shown that an incorrect assumption of a binomial distribution of chromosome segments, and failing to take account of a reduction in variance in genomic proportion due to selection, can lead to a downward bias of up to two generations in the estimation of the number of generations required for the formation of a congenic strain.

Type
SHORT PAPER
Information
Genetics Research , Volume 74 , Issue 1 , August 1999 , pp. 81 - 85
Copyright
© 1999 Cambridge University Press