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Tich: a mutant causing disproportional growth in the mouse

Published online by Cambridge University Press:  14 April 2009

James R. Archer ,
Victoria A. Archer ,
Michael F. W. Festing  and
Mirian A. Ghiraldini
James R. Archer
Affiliation:
Bone, Tooth and Biomaterials Group, Bone and Joint Research Unit, London Hospital Medical College, London E1 2AD
Victoria A. Archer
Affiliation:
Britton's School, Rainham, Essex
Michael F. W. Festing
Affiliation:
MRC Toxicology Unit, Woodmansterne Road, Carshalton, Surrey
Mirian A. Ghiraldini
Affiliation:
Escola Paulista de Medicina, São Paulo, Brazil

Summary

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A spontaneous mutation ‘tich’ (gene symbol tch) appeared as a recessive mutation in inbred mice of strain A. TL. Homozygotes are rather dumpy mice of approximately normal weight but with short limbs and tail. Skeletal measurements on backcross siblings show that the mandible bones are almost normal but long bones and some parts of the pelvic and pectoral girdles are short. Although tich resembles brachypodism phenotypically it is not linked to agouti, and does not match the description of any other skeletal mutation. There was some evidence for weak linkage with albinism on chromosome 7. The mutation has reappeared amongst the A. TL mice of a UK commercial breeder and may have been accepted as the norm for A. TL amongst some European users of this mouse.

Type
Research Article
Information
Genetics Research , Volume 57 , Issue 1 , February 1991 , pp. 29 - 35
Copyright
Copyright © Cambridge University Press 1991

References

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