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Why do health technology assessment drug reimbursement recommendations differ between countries? A parallel convergent mixed methods study

Published online by Cambridge University Press:  06 September 2019

Elena Nicod Open the ORCID record for Elena Nicod [Opens in a new window] ,
Laia Maynou Open the ORCID record for Laia Maynou [Opens in a new window] ,
Erica Visintin  and
John Cairns
Elena Nicod*
Affiliation:
Bocconi University, Centre for Research on Health and Social Care Management (CERGAS), Milano, Lombardia, Italy
Laia Maynou
Affiliation:
Department of Health Policy, London School of Economics and Political Science (LSE), London, UK Centre for Research in Health and Economics (CRES), University of Pompeu Fabra, Barcelona, Spain
Erica Visintin
Affiliation:
Department of Social Policy, London School of Economics and Political Science (LSE), London, UK
John Cairns
Affiliation:
Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK
*
*Corresponding author. Email: elena@nicod.com
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Abstract

Using quantitative and qualitative research designs, respectively, two studies investigated why countries make different health technology assessment (HTA) drug reimbursement recommendations. Building on these, the objective of this study was to (a) develop a conceptual framework integrating the factors explaining these decisions, (b) explore their relationship and (c) assess if they are congruent, complementary or discrepant. A parallel convergent mixed methods design was used. Countries included in both previous studies were selected (England, Sweden, Scotland and France). A conceptual framework that integrated and organised the factors explaining the decisions from the two studies was developed. Relationships between factors were explored and illustrated through case studies. The framework distinguishes macro-level factors from micro-level ones. Only two of the factors common to both studies were congruent, while two others reached discrepant conclusions (stakeholder input and external review of the evidence processes). The remaining factors identified within one or both studies were complementary. Bringing together these findings contributed to generating a more complete picture of why countries make different HTA recommendations. Results were mostly complementary, explaining and enhancing each other. We conclude that differences often result from a combination of factors, with an important component relating to what occurs during the deliberative process.

Keywords

Conceptual frameworkHTA recommendationsmixed methods
Type
Articles
Information
Health Economics, Policy and Law , Volume 15 , Issue 3 , July 2020 , pp. 386 - 402
Copyright
Copyright © Cambridge University Press 2019

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