Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-28T02:58:03.046Z Has data issue: false hasContentIssue false

Analysis of Multidrug-Resistant Organism Susceptibility to Chlorhexidine Under Usual Clinical Care

Published online by Cambridge University Press:  11 April 2017

Jackson S. Musuuza
Affiliation:
William S. Middleton Memorial Veterans Affairs Hospital, Madison, Wisconsin Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Ajay K. Sethi
Affiliation:
Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin
Tonya J. Roberts
Affiliation:
William S. Middleton Memorial Veterans Affairs Hospital, Madison, Wisconsin School of Nursing, University of Wisconsin, Madison, Wisconsin
Nasia Safdar*
Affiliation:
William S. Middleton Memorial Veterans Affairs Hospital, Madison, Wisconsin Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
*
Address correspondence to Nasia Safdar, MD, PhD, UWMF Centennial Building, 1685 Highland Avenue, Madison, WI 53705 (ns2@medicine.wisc.edu).

Abstract

Increasing use of daily chlorhexidine gluconate (CHG) bathing can potentially lead to selection for organisms with reduced susceptibility to CHG, limiting the utility of CHG. We examined reduced susceptibility to CHG of fluoroquinolone-resistant gram-negative bacilli and methicillin-resistant Staphylococcus. No evidence suggested reduced susceptibility to CHG.

Infect Control Hosp Epidemiol 2017;38:729–731

Type
Concise Communications
Copyright
© 2017 by The Society for Healthcare Epidemiology of America. All rights reserved 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Zimlichman, E, Henderson, D, Tamir, O, et al. Health care–associated infections: a meta-analysis of costs and financial impact on the us health care system. JAMA Intern Med 2013;173:20392046.CrossRefGoogle ScholarPubMed
2. Horner, C, Mawer, D, Wilcox, M. Reduced susceptibility to chlorhexidine in staphylococci: is it increasing and does it matter? J Antimicrob Chemother 2012;67:25472559.Google Scholar
3. Milstone, AM, Passaretti, CL, Perl, TM. Chlorhexidine: expanding the armamentarium for infection control and prevention. Clin Infect Dis 2008;46:274281.Google ScholarPubMed
4. Climo, MW, Yokoe, DS, Warren, DK, et al. Effect of daily chlorhexidine bathing on hospital-acquired infection. N Engl J Med 2013;368:533542.Google Scholar
5. Shuman, E, Harpe, J, Calfee, DP. Survey of hospital practices regarding use of chlorhexidine gluconate bathing for prevention of healthcare-associated infections. Open Forum Infectious Diseases 2014;1:S363S364.Google Scholar
6. Edmiston, CE, Krepel, CJ, Seabrook, GR, Lewis, BD, Brown, KR, Towne, JB. Preoperative shower revisited: can high topical antiseptic levels be achieved on the skin surface before surgical admission? J Am Coll Surg 2008;207:233239.Google Scholar
7. Suwantarat, N, Carroll, KC, Tekle, T, et al. High prevalence of reduced chlorhexidine susceptibility in organisms causing central line-associated bloodstream infections. Infect Control Hosp Epidemiol 2014;35:11831186.Google Scholar
8. Sheng, WH, Wang, JT, Lauderdale, TL, Weng, CM, Chen, D, Chang, SC. Epidemiology and susceptibilities of methicillin-resistant Staphylococcus aureus in Taiwan: emphasis on chlorhexidine susceptibility. Diagn Microbiol Infect Dis 2009;63:309313.Google Scholar
9. Higgins, CS, Murtough, SM, Williamson, E, et al. Resistance to antibiotics and biocides among non-fermenting gram-negative bacteria. Clin Microbiol Infect 2001;7:308315.Google Scholar
10. Wang, JT, Sheng, WH, Wang, JL, et al. Longitudinal analysis of chlorhexidine susceptibilities of nosocomial methicillin-resistant Staphylococcus aureus isolates at a teaching hospital in Taiwan. J Antimicrob Chemother 2008;62:514517.Google Scholar