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Antimicrobial Use Prior to the Acquisition of Multiresistant Bacteria

Published online by Cambridge University Press:  02 January 2015

Matthieu Eveillard*
Affiliation:
Department of Bacteriology, Hygiene and Infection Control, Centre Hospitalier Universitaire, Hôpital Nord, Amiens, France
Jean-Luc Schmit
Affiliation:
Department of Infectious Diseases, Centre Hospitalier Universitaire, Hôpital Nord, Amiens, France
François Eb
Affiliation:
Department of Bacteriology, Hygiene and Infection Control, Centre Hospitalier Universitaire, Hôpital Nord, Amiens, France
*
Unité d'Hygiène el de Prévention des Infections Nosocomiales, Centre Hospitalier Universitaire d'Amiens, Hôpital Nord, 80054 Amiens Cedex 1, France

Abstract

We assessed whether patients who acquired methicillin-resistant Staphylococcus aureus (MRSA) had less exposure to antimicrobial agents than did those who acquired Enterobacteriaceae that produced extended-spectrum β-lactamase (ESβL). In a 6-month, prospective study, ESβL carriers had received antimicrobial therapy more often than had MRSA carriers. Amoxicillin-clavulanic acid, fluoroquinolones, and third-generation cephalosporins, especially ceftazidime, had been prescribed more often for ESβL carriers than for MRSA carriers.

Type
Concise Communications
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2002

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References

1.Shlaes, DM, Gerding, DN, John, JF, et al. Society for Healthcare Epidemiology of America and Infectious Diseases Society of America Joint Committee on the Prevention of Antimicrobial Resistance: guidelines for the prevention of antimicrobial resistance in hospitals. Infect Control Hosp Epidemiol 1997;18:275291.CrossRefGoogle ScholarPubMed
2.Ayliffe, GAJ. The progressive intercontinental spread of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 1997;24(suppl 1):7479.CrossRefGoogle ScholarPubMed
3.Meyer, KS, Urban, C, Eagan, JA, Berger, BJ, Rahal, JJ. Nosocomial outbreak of Klebsiella infection resistant to late-generation cephalosporins. Ann Intern Med 1993;119:353358.CrossRefGoogle ScholarPubMed
4.Naumovski, L, Quinn, JP, Miyashiro, D. Outbreak of ceftazidime resistance due to a novel extended-spectrum β-lactamase in isolates from cancer patients. Antimicrob Agents Chemother 1992;36:19911996.CrossRefGoogle ScholarPubMed
5.Crowcroft, NS, Ronveaux, O, Monnet, DL, Mertens, R. Methicillin-resistant Staphylococcus aureus and antimicrobial use in Belgian hospitals. Infect Control Hosp Epidemiol 1999;20:3136.CrossRefGoogle ScholarPubMed
6.Monnet, DL. Methicillin-resistant Staphylococcus aureus and its relationship to antimicrobial use: possible implications for control. Infect Control Hosp Epidemiol 1998;19:552559.CrossRefGoogle ScholarPubMed
7.Comité de l'Antibiogramme de la Société Française de Microbiologie. Communiqué 1998. Pathol Biol 1998;46:IXVI.Google Scholar
8.Jarlier, V, Nicolas, MH, Fournier, G, Philippon, A. Extended broad-spectrum β-lactamases conferring transferable resistance to newer β-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns. Reviews of Infectious Diseases 1988;10:867878.CrossRefGoogle ScholarPubMed
9.Bosi, C, Davin-Regli, A, Bornet, C, Mallea, M, Pages, JM, Bollet, C. Most Enterobacter aerogenes strains in France belong to a prevalent clone. J Clin Microbiol 1999;37:21652169.CrossRefGoogle ScholarPubMed
10.Pujol, M, Pena, C, Pallares, R, Ariza, J, Ayats, J, Dominguez, MA. Nosocomial Staphylococcus aureus bacteremia among nasal carriers of methicillin-resistant and methicillin-susceptible strains. Am J Med 1996;100:509516.CrossRefGoogle ScholarPubMed
11.Pechere, JC, Vladoianu, IR. Development of resistance during ceftazidime and cefepime therapy in a murine peritonitis model. J Antimicrob Chemother 1992;29:563573.CrossRefGoogle Scholar
12.Negri, MC, Baquero, F. In vitro selective concentrations of cefepime and ceftazidime for AmpC beta-lactamase hyperproducer Enterobacter cloacae variants. Clinical Microbiology and Infection 1999;5(suppl 1):S25S28.CrossRefGoogle ScholarPubMed
13.Rice, LB, Eckstein, EC, DeVente, J, Shlaes, M. Ceftazidime-resistant Klebsiella pneumoniae isolates recovered at the Cleveland Department of Veterans Affairs Medical Center. Clin Infect Dis 1996;23:118124.CrossRefGoogle ScholarPubMed