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Association between Methicillin-Resistant Staphylococcus aureus Colonization and Infection May Not Differ by Age Group

Published online by Cambridge University Press:  02 January 2015

Adebola O. Ajao
Affiliation:
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland
Anthony D. Harris
Affiliation:
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland
J. Kristie Johnson
Affiliation:
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland
Mary-Claire Roghmann
Affiliation:
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland Veterans Affairs Maryland Health Care System, Baltimore, Maryland
Eli N. Perencevich
Affiliation:
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
Marin L. Schweizer
Affiliation:
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
Min Zhan
Affiliation:
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland
Wilbur H. Chen
Affiliation:
Veterans Affairs Maryland Health Care System, Baltimore, Maryland
Jon P. Furuno*
Affiliation:
Department of Pharmacy Practice, Oregon State University /Oregon Health and Science University College of Pharmacy, Portland, Oregon
*
OSU/OHSU College of Pharmacy, Department of Pharmacy Practice, 3303 SW Bond Avenue, CH12C, Portland, OR 97239 (furuno@ohsu.edu)

Abstract

We assessed whether age modified the association between methicillin-resistant Staphylococcus aureus (MRSA) anterior nares colonization and subsequent infection. Among 7,405 patients (9,511 admissions), MRSA colonization was significantly associated with infection (adjusted odds ratio, 13.7 [95% confidence interval, 7.325.7]) but did not differ significantly by age group.

Type
Concise Communication
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2013

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References

1. Cosgrove, SE, Sakoulas, G, Perencevich, EN, Schwaber, MJ, Karchmer, AW, Carmeli, Y. Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis 2003;36:5359.10.1086/345476Google Scholar
2. Mest, DR, Wong, DH, Shimoda, KJ, Mulligan, ME, Wilson, SE. Nasal colonization with methicillin-resistant Staphylococcus aureus on admission to the surgical intensive care unit increases the risk of infection. Anesth Analg 1994;78:644650.10.1213/00000539-199404000-00005Google Scholar
3. Roghmann, MC, Siddiqui, A, Plaisance, K, Standiford, H. MRSA colonization and the risk of MRSA bacteraemia in hospitalized patients with chronic ulcers. J Hosp Infect 2001;47:98103.10.1053/jhin.2000.0903Google Scholar
4. Harris, AD, Furuno, JP, Roghmann, MC, et al. Targeted surveillance of methicillin-resistant Staphylococcus aureus and its potential use to guide empiric antibiotic therapy. Antimicrob Agents Chemother 2010;54:31433148.10.1128/AAC.01590-09Google Scholar
5. Furuno, JP, McGregor, JC, Harris, AD, et al. Identifying groups at high risk for carriage of antibiotic-resistant bacteria. Arch Intern Med 2006;166:580585.10.1001/archinte.166.5.580Google Scholar
6. Horan, TC, Andrus, M, Dudeck, MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008;36:309332.10.1016/j.ajic.2008.03.002Google Scholar
7. Deyo, RA, Cherkin, DC, Ciol, MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992;45:613619.10.1016/0895-4356(92)90133-8Google Scholar
8. Pujol, M, Pena, C, Pallares, R, et al. Nosocomial Staphylococcus aureus bacteremia among nasal carriers of methicillin-resistant and methicillin-susceptible strains. Am J Med 1996;100:509516.10.1016/S0002-9343(96)00014-9Google Scholar
9. Graffunder, EM, Venezia, RA. Risk factors associated with nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection including previous use of antimicrobials. J Antimicrob Chemother 2002;49:9991005.10.1093/jac/dkf009Google Scholar