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Comparative Killing Kinetics of Methicillin-Resistant Staphylococcus aureus by Bacitracin or Mupirocin

Published online by Cambridge University Press:  02 January 2015

Edward K. Chapnick ,
Jeremy D. Gradon ,
Barry Kreiswirth ,
Larry I. Lutwick ,
Benjamin C. Schaffer ,
Thomas D. Schiano  and
Michael H. Levi
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Abstract

The in vitro activities of bacitracin and mupirocin were compared for seven different strains of methicillin-resistant Staphylococcus aureus. Six of seven strains showed bacitracin minimum inhibitory concentrations (MICs) of 0.5 to 1.0 units/mL, and all seven had mupirocin MICs of 0.5 to 2 μg/mL. Time-kill studies revealed 2.6- to 4.5-log reduction in 24 hours with strains susceptible to bacitracin (4 units/mL) and 0 to 2.2 reduction with mupirocin (16 μg/mL). Bacitracin should be considered further for in vivo studies because of enhanced bacteriocidal effect and lower cost.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 17 , Issue 3 , March 1996 , pp. 178 - 180
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1996

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