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A Hepatitis B Vaccination Program in a Community Teaching Hospital

Published online by Cambridge University Press:  02 January 2015

Myron J. Tong ,
Ann M. Howard ,
Gary C. Schatz ,
Mark A. Kane ,
Deborah A. Roskamp ,
Ruth L. Co  and
Cissy Boone
Myron J. Tong*
Affiliation:
Liver Center, Huntington Memorial Hospital, Pasadena, California, and the Centers for Disease Control, Atlanta, Georgia
Ann M. Howard
Affiliation:
Liver Center, Huntington Memorial Hospital, Pasadena, California, and the Centers for Disease Control, Atlanta, Georgia
Gary C. Schatz
Affiliation:
Liver Center, Huntington Memorial Hospital, Pasadena, California, and the Centers for Disease Control, Atlanta, Georgia
Mark A. Kane
Affiliation:
Liver Center, Huntington Memorial Hospital, Pasadena, California, and the Centers for Disease Control, Atlanta, Georgia
Deborah A. Roskamp
Affiliation:
Liver Center, Huntington Memorial Hospital, Pasadena, California, and the Centers for Disease Control, Atlanta, Georgia
Ruth L. Co
Affiliation:
Liver Center, Huntington Memorial Hospital, Pasadena, California, and the Centers for Disease Control, Atlanta, Georgia
Cissy Boone
Affiliation:
Liver Center, Huntington Memorial Hospital, Pasadena, California, and the Centers for Disease Control, Atlanta, Georgia
*
Liver Center, Huntington Memorial Hospital, 100 Congress Street, Pasadena, CA 91105
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Abstract

Prior to offering the hepatitis B (HB) vaccine, a prescreen for hepatitis B virus (HBV) antibodies was conducted in a 565 bed hospital in Pasadena, California. Antibodies to the hepatitis B virus were detected in 14.5% of 1,745 employees tested. There was a significantly higher prevalence in those with a previous history of hepatitis, blood transfusions, exposure to nee-dlesticks, number of years in the same occupation, and in the same hospital work area. Employees of Asian extraction (33.3%) and blacks (23.1%) had a higher prevalence of antibodies to the hepatitis B virus than Hispanics (13.7%) and whites (10.2%). Anti-HBs was detected in 92.6% of 865 employees who received three doses of the hepatitis B vaccine. Only 28.6% of nonresponders receiving a fourth dose of hepatitis B vaccine produced anti-HBs. The nonresponders to the HB vaccine were older (average age 64.9 years) when compared to the responders (average age 37.5 years), and more males failed to produce anti-HBs after vaccination than females. Hepatitis B vaccination of the majority of individuals with either “low level” anti-HBs alone or anti-HBc alone did not elicit an anamnestic response after one dose of vaccine, implying that these “low level” antibodies are nonspecific and do not represent antiviral antibodies. Adverse reactions to the hepatitis B vaccine were minor and included a flulike syndrome, sore arm, and rash and swelling at the injection site. The reasons for nonparticipation were obtained from 179 individuals, and the main issue was concern about safety of the hepatitis B vaccine.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 8 , Issue 3 , March 1987 , pp. 102 - 107
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1987

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