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Diabetes and Risk of Surgical Site Infection: A Systematic Review and Meta-analysis

Published online by Cambridge University Press:  27 October 2015

Emily T. Martin ,
Keith S. Kaye ,
Caitlin Knott ,
Huong Nguyen ,
Maressa Santarossa ,
Richard Evans ,
Elizabeth Bertran  and
Linda Jaber
Emily T. Martin*
Affiliation:
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan
Keith S. Kaye
Affiliation:
Division of Infectious Diseases, Wayne State University and Detroit Medical Center, Detroit, Michigan
Caitlin Knott
Affiliation:
Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan
Huong Nguyen
Affiliation:
Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan
Maressa Santarossa
Affiliation:
Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan
Richard Evans
Affiliation:
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan
Elizabeth Bertran
Affiliation:
Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan
Linda Jaber
Affiliation:
Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan
*
Address correspondence to Emily T. Martin, MPH, PhD, Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, Michigan, USA 48109-2029 (etmartin@umich.edu).
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Abstract

OBJECTIVE

To determine the independent association between diabetes and surgical site infection (SSI) across multiple surgical procedures.

DESIGN

Systematic review and meta-analysis.

METHODS

Studies indexed in PubMed published between December 1985 and through July 2015 were identified through the search terms “risk factors” or “glucose” and “surgical site infection.” A total of 3,631 abstracts were identified through the initial search terms. Full texts were reviewed for 522 articles. Of these, 94 articles met the criteria for inclusion. Standardized data collection forms were used to extract study-specific estimates for diabetes, blood glucose levels, and body mass index (BMI). A random-effects meta-analysis was used to generate pooled estimates, and meta-regression was used to evaluate specific hypothesized sources of heterogeneity.

RESULTS

The primary outcome was SSI, as defined by the Centers for Disease Control and Prevention surveillance criteria. The overall effect size for the association between diabetes and SSI was odds ratio (OR)=1.53 (95% predictive interval [PI], 1.11–2.12; I2, 57.2%). SSI class, study design, or patient BMI did not significantly impact study results in a meta-regression model. The association was higher for cardiac surgery 2.03 (95% PI, 1.13–4.05) compared with surgeries of other types (P=.001).

CONCLUSIONS

These results support the consideration of diabetes as an independent risk factor for SSIs for multiple surgical procedure types. Continued efforts are needed to improve surgical outcomes for diabetic patients.

Infect. Control Hosp. Epidemiol. 2015;37(1):88–99

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 37 , Supplement 1 , January 2016 , pp. 88 - 99
Copyright
© 2015 by The Society for Healthcare Epidemiology of America. All rights reserved 

Diabetes prevalence is increasing in the United States,Reference Cheng, Imperatore, Geiss, Wang, Saydah and Cowie 1 and the appropriate management of patients with diabetes has become increasingly important for the prevention of hospital-acquired infections. Much has been published in recent years about the impact of diabetes on increased rates of surgical site infection (SSI) and the potentially related impact of hyperglycemia on SSI. Surgical site infections are estimated to have an annual financial impact of more than $3 billion dollars nationally and are the largest contributor to the overall cost of healthcare-associated infections.Reference Zimlichman, Henderson, Tamir, Franz, Song and Yamin 2 Efforts to reduce the rates of SSIs are becoming more urgent since the introduction of Centers for Medicare and Medicaid Services penalties for hospital readmission rates. An understanding of patient risk factors for SSI is key to these efforts because hospitals with a more vulnerable case mix are more likely to incur readmission penalties.Reference Joynt and Jha 3 Furthermore, the substantial prevalence of hospital-associated infections due to antibiotic resistant pathogensReference Sievert, Ricks, Edwards, Schneider, Patel and Srinivasan 4 highlights the importance of prevention in individuals at high risk of infection. To gain a greater understanding of the impact of pre-existing diabetes on the incidence of SSI, we performed a meta-analysis of risk factors for SSIs among patients undergoing surgery in US hospitals. We hypothesize that pre-existing diabetes is a significant contributor to the development of SSI, independently of hyperglycemia at the time of surgery. Secondarily, we hypothesize that hyperglycemia is itself an independent contributor to increased risk of SSI in surgical patients.

METHODS

A systematic literature search and meta-analysis was performed following MOOSE guidelinesReference Stroup, Berlin, Morton, Olkin, Williamson and Rennie 5 (Online Supplementary Material).

Data Sources and Searches

A systematic literature search was performed by 4 study investigators (M.S., C.K., H.N., R.E.) with questions referred to an adjudication team consisting of the study principal investigator (E.T.M.), 1 investigator with expertise in diabetes epidemiology (L.J.), and 1 investigator with expertise in infectious diseases and infection prevention (K.S.K.). The search was performed in PubMed and EMBASE using combinations of the search terms “risk factors,” “diabetes,” “glucose,” and “surgical site infections” from December 1985 to July 2015 (see Online Supplementary Material: Search Strategy). The starting date of the search, December 1985, was selected to correspond with the wide implementation of the Centers for Disease Control and Prevention (CDC) SSI surveillance guidelines. The search was inclusive of all study designs unless interventional control of glucose during the study prevented an assessment of the association between diabetes and SSI.

Study Selection

All abstracts were reviewed for eligibility, and the full-article texts of potentially relevant studies were reviewed in depth. Reference lists for all reviewed articles were hand-searched to identify additional eligible articles. Eligibility criteria for study inclusion were the following: (1) original US data; (2) adult participants; (3) utilized the CDC definition for SSIs; and (4) included measurable risk estimates of the association between diabetes and risk of SSI with 95% confidence intervals or provided adequate information to calculate risk estimates and their 95% confidence intervals. Review articles, meta-analyses, or non-English studies were excluded (Online Supplementary Material: List of Excluded Studies).

Eligible studies included adult patients undergoing surgical procedures of any type, using NHSN operative procedure categories to define surgical procedures. All comparative study designs (including observational, randomized controlled, retrospective, or prospective studies) were considered for inclusion provided they presented an assessment for the association between diabetes and SSI or the absolute patient numbers needed for the calculation of the measure. Each eligible study was required to include both diabetic and non-diabetic patients in the study population. Multiple publications on the same subject population were reviewed together and were restricted such that each patient population was included only once; this is notable particularly for multiple publications from large surveillance databases (eg, National Surgical Quality Improvement Program; see Online Supplementary Material: Excluded Studies). SSI was defined using criteria specified by the CDC for the purposes of surveillance and reporting.

Data Extraction

Measures for the association between pre-existing diabetes and SSI were collected from studies that ascertained the presence of diabetes prior to the time of surgery either through the patient’s medical record or hemoglobin A1c testing (HbA1c). Assessments of HbA1c levels were noted; however, not enough studies were identified to merit a separate meta-analysis based on this measure. Measures of the association between peri- or post-operative blood glucose levels were collected from studies that assessed thresholds of glucose levels. Studies that presented only comparisons of mean or median blood glucose levels were excluded from the analysis of peri- or post-operative hyperglycemia due to our inability to define the absolute number of patients with hyperglycemia in the infected and uninfected groups.

Data were abstracted onto standardized forms that included study characteristics, study population, type of SSI (superficial, deep incisional, or organ/space), crude and adjusted estimates, and confidence intervals. For each study, we recorded how diabetes was determined and whether blood glucose was measured prior to, during, or after surgery. Studies were assigned to the following categories based on the type of surgery: obstetrical and gynecological, colorectal, arthroplasty, breast, cardiac, spinal, or other. The abstraction team received training by the principal investigator, including the abstraction of multiple practice cases, before performing data abstraction. A subset of studies included was re-reviewed by 2 study investigators to ensure consistency.

Data Synthesis and Analysis

The most-adjusted estimate (ie, the adjusted odds ratio for the multivariate regression with the most variables) was used to generate summary estimates.Reference Petitti 6 Summary estimates and predictive intervals were calculated using a DerSimonian and Laird random-effects model for each estimate type. Confidence intervals were used for smaller analyses of diabetes and glucose combined models. The use of random-effects models was based on I2 values exceeding 30% in each overall fixed-effects analysis.Reference Higgins and Green 7 Funnel plots were generated to assess publication bias (data not shown) (Stata 11, StataCorp, College Station, TX). Sensitivity analysis was performed through the generation of stratified estimates and the use of multiple meta-regression analyses to assess the presence of meta-confounding by study characteristics including surgery type, study type, inclusion of body mass index (BMI) in the adjusted estimate, and diabetes prevalence in the study population. We determined a priori that the primary confounder of concern was BMI.

RESULTS

The combined search strategies identified 3,631 abstracts. All of these abstracts were reviewed, and the full texts of 522 articles were reviewed in depth; 3,109 studies were excluded during abstract review (Figure 1), and 428 studies were excluded during full-text review (Online Supplementary Material: List of Excluded Studies).

FIGURE 1 Flow diagram of search and selection processes.

Meta-analysis for Diabetes and SSI

A total of 90 studies provided estimates for the association between diabetes and SSI, including 2 studies that provided multiple estimates (Appendix Table 1). Included studies comprised a total of 866,427 procedures and 32,067 SSIs meeting CDC surveillance criteria. All studies were observational with the exception of 3 randomized controlled trials. We identified 14 studies (16%) that used prospectively collected data. Diabetes prevalence among included study populations ranged from 2% to 39% (median 17%). History of diabetes was ascertained by medical record review in all but 2 studies.Reference Latham, Lancaster, Covington, Pirolo and Thomas 8 , Reference Liang, Li, Avellaneda, Moffett, Hicks and Awad 9 No included studies differentiated between Type 1 and Type 2 diabetes.

The overall effect size for the association between diabetes and SSI was an odds ratio (OR) of 1.53 (95% predictive interval [PI], 1.11–2.12; I2, 57.2%) (Figure 2). Of the included studies, 38 (42%) provided estimates that were adjusted for potential confounding factors. When stratifying the meta-analysis by the availability of crude versus adjusted measures, the effect size was similar (OR, 1.68; 95% PI, 1.03–2.72; I2, 63.6%) for all available crude measures (71 studies); OR was 1.77 (95% PI, 1.13–2.78); I2, 71.1%) for all adjusted measures (38 studies). Funnel plots demonstrated greater evidence of potential publication bias for adjusted estimates (data not shown).

FIGURE 2 Meta-analysis of diabetes and surgical site infection, by surgery type.

Evaluation of Sources of Heterogeneity for Diabetes Estimate

Study design did not have a significant impact on the overall pooled estimate (P=.13 for retrospective vs prospective data collection; P=.41 for case-control vs cohort or interventional design). Prevalence of diabetes among study participants was also not a significant source of heterogeneity (P=.80). Among studies presenting estimates restricted to specific SSI classes, the combined OR was 1.95 (95% PI, 0.65–5.87) for deep SSIs (7 estimates from 6 studies) and the OR was 1.38 (95% PI, 0.66–2.88) for superficial SSIs (6 estimates from 5 studies).

Among studies reporting on a single surgical category, the most common category was cardiac (15 studies) followed by spinal (14 studies) (Table 1). Estimates by surgery type for the association between diabetes and SSI ranged from 1.16 for colorectal surgeries (95% PI, 0.93–1.44) to 2.03 for cardiac surgeries (95% PI, 1.13–4.05) (Table 1). Meta-regression for impact of surgery type on the association between diabetes and SSI indicated that the combined SSI effect was higher for cardiac surgery than for all other surgery categories (P=.001). BMI was hypothesized a priori to be an important confounder in the association between diabetes and SSI. Study estimates were stratified according to whether the presented measure controlled for the effect of BMI. The estimate pooled from the 20 studies that controlled for BMI was higher than that pooled from those that did not; however, this factor was not significant when evaluated by meta-regression (P=.79).

TABLE 1 Pooled Estimates of the Association between Diabetes and Surgical Site Infection by Surgery Type

Meta-analysis for Blood Glucose and SSI

In total, 16 studies were available to assess the association between hyperglycemia and SSI, with 10 papers (n=27,844 procedures) including pre- or intraoperative assessments of blood glucose levels and 11 papers (n=32,625 procedures) including postoperative assessments of blood glucose levels. We observed a wide range in the threshold for defining hyperglycemia. Of 10 studies assessing pre-operative blood glucose, 6 used a threshold of 200 mg/dL, and the remaining 3 studies used thresholds of 125 mg/dL (2 studies), 180 mg/dL (1 study), and 100 mg/dL (1 study). Of the 11 studies assessing post-operative blood glucose, 5 used thresholds of 200 mg/dL, with the remaining studies using lower thresholds ranging from 125 mg/dL to 180 mg/dL. One paper presented a composite exposure of pre- or postoperative hyperglycemia, and this estimate was included in both pooled calculations.Reference Olsen, Nepple, Riew, Lenke, Bridwell and Mayfield 10 The overall estimate for the association between elevated blood glucose and SSI in the pre- or intraoperative period was OR=1.88 (95% Predictive Interval [PI], 0.66–5.34) (Figure 3). The overall estimate for the association between elevated blood glucose in the post-operative period and SSI was 1.45 (95% PI, 0.77–3.04) (Figure 4).

FIGURE 3 Meta-analysis of pre-operative hyperglycemia and surgical site infection.

FIGURE 4 Meta-analysis of post-operative hyperglycemia and surgical site infection.

Only 3 studies presented multivariate models adjusting for blood glucose levels and diabetes in the same model.Reference Latham, Lancaster, Covington, Pirolo and Thomas 8 , Reference Olsen, Nepple, Riew, Lenke, Bridwell and Mayfield 10 , Reference Wilson and Sexton 11 These studies used thresholds of ≥200 mg/dLReference Latham, Lancaster, Covington, Pirolo and Thomas 8 and ≥126 mg/dLReference Wilson and Sexton 11 to define elevated preoperative glucose levels or combined pre- and postoperative thresholds into a single definition.Reference Olsen, Nepple, Riew, Lenke, Bridwell and Mayfield 10 Pooled estimates of the association between diabetes and SSI, controlling for glucose level was OR=2.55 (95% confidence interval [CI], 1.70–3.82). Pooled estimates of the association between elevated glucose level and SSI, controlling for a history of diabetes was OR=2.22 (95% CI, 1.36–3.60).

DISCUSSION

Consistency of Included Studies

We limited our analysis to studies performed at U.S. hospitals after 1985 in an effort to narrow our review to surgeries evaluated with the standard SSI surveillance methods and definitions required by the CDC. We observed some variation in the definitions for hyperglycemia among included studies. Approximately half of the studies used thresholds that met or were more conservative than those proposed by the Society of Thoracic SurgeonsReference Lazar, McDonnell, Chipkin, Furnary, Engelman and Sadhu 12 and the American Diabetes Association. 13 The remaining studies used a slightly higher threshold of 200 mg/dL to define hyperglycemia, and it is possible that this variation may have introduced heterogeneity into our combined estimates for hyperglycemia.

Almost all included studies used medical record review to assess a patient’s reported history of diabetes. This data may be prone to error and may not reliably identify all patients with diabetes or assess the degree to which an individual patient’s diabetic condition is adequately controlled. Likewise, the assessment of diabetes for use with the revised surgical risk index from the Centers of Disease Control does not recommend the use of HbA1c or other markers of severity of diabetes to gather risk information.Reference Mu, Edwards, Horan, Berrios-Torres and Fridkin 14

Generalizability of Study Estimate

Our requirement that all studies be based in the United States excluded available data from other countries; however, it allowed us to strictly assess SSIs using CDC definitions from hospitals participating in standardized surveillance procedures. While specific quality ratings were not performed for each study, we explored several potential sources of heterogeneity in our pooled estimates through the use of meta-regression. Our stratum-specific estimates show a very consistent association between diabetes and SSIs across categories, including study characteristics, and after controlling for BMI. We were unable to assess variation due to SSI surveillance practices in different hospitals. While studies using active follow-up protocols would be expected to have increased SSI rates, we do not expect that this effect would be differential by diabetes status. Our pooled estimates are based on the use of the most adjusted estimate available in each study.Reference Petitti 6 To assess the impact of this rule, summary estimates were generated separately for all available crude effects and all available adjusted effects, and the findings in these models were similar to the most-adjusted models. The funnel plot for the adjusted estimates indicates the possible presence of publication bias for these estimates in this body of literature (data not shown). This bias is likely due to the tendency of authors to publish only those variables that are significant in multivariate analyses. Given our findings of an association between diabetes and SSI in almost every category of surgery type, it is likely that non-significant findings for diabetes in smaller studies may be due to insufficient sample size in individual studies, rather than a lack of underlying impact. For that reason, it may be prudent to include diabetes as an a priori hypothesized risk factor in future studies with the inclusion of diabetes in adjusted models for risk of SSIs.

Interpretation of Findings

Our finding of increased SSI among patients with diabetes was consistent across surgery types, with the exception of obstetrical and gynecological surgery which was based on 2 studies conducted at the same hospital. The surgery-specific findings were statistically significant for arthroplasty, breast, cardiac, and spinal surgeries; the actual pooled estimate was highest among patients undergoing cardiac surgery. These findings contrast with the analysis of National Healthcare Safety Network data that served as the basis for the revised procedure-specific SSI risk-adjustment calculations. This analysis found diabetes to only be associated with SSI for spinal fusion or refusion.Reference Mu, Edwards, Horan, Berrios-Torres and Fridkin 14 In patients with diabetes receiving colorectal resection, glucose levels were consistently higher in patients with an SSI compared with uninfected patients, even when mean glucose levels were below 200 mg/dL in those with or without SSI.Reference Sehgal, Berg, Figueroa, Poritz, McKenna and Stewart 15 Similar findings have been reported in patients undergoing laminectomy.Reference Friedman, Sexton, Connelly and Kaye 16 Elevated blood glucose has been found to be associated with increased rates of infection in orthopaedic spine surgery,Reference Caputo, Dobbertien, Ferranti, Brown, Michael and Richardson 17 cardiac surgery,Reference Wilson and Sexton 11 , Reference Furnary, Zerr, Grunkemeier and Starr 18 , Reference Zerr, Furnary, Grunkemeier, Bookin, Kanhere and Starr 19 and colorectal and bariatric surgeryReference Kwon, Thompson, Dellinger, Yanez, Farrohki and Flum 20 ; however, this association has not been consistently found.Reference Hardy, Nowacki, Bertin and Weil 21 , Reference Jeon, Furuya, Berman and Larson 22

The notion that diabetes is a significant contributor to SSI risk through mechanisms other than hyperglycemia at the time of surgery is supported by the few studies that included both glucose levels and history of diabetes in the multivariate models. In the pooled estimate from these studies, the magnitude of the effect of diabetes was stronger than that of our primary analysis that included all eligible studies. The results of an interventional study by Trussel et alReference Trussell, Gerkin, Coates, Brandenberger, Tibi and Keuth 23 corroborates this finding. Diabetes remained a significant risk factor for SSI with an odds ratio of 4.71 despite the implementation of a patient care pathway targeting glucose control during the time of surgery and resulting in successfully reducing the overall rates of infection. However, we identified few studies suitable for analysis of potential independent effects of diabetes and hyperglycemia on SSI.

CONCLUSIONS

In our study, we found a significant association between diabetes and SSI that was consistent across multiple types of surgeries and after controlling for BMI. While we also confirmed an association between both pre- and post-operative hyperglycemia and SSI, history of diabetes remained a significant risk factor in meta-analyses of studies that controlled for hyperglycemia.

Furthermore, we found diabetes to be a significant contributor to the risk of SSIs, potentially beyond its role in causing hyperglycemia during or after surgery. The reasons for this finding are unclear. It is possible that diabetes is a marker for other conditions that may put a patient at risk of infection, including vascular changes and white blood cell dysfunction. In addition, the occurrence of perioperative hyperglycemia and subsequent immune suppression is affected by the complex contributions of factors in addition to the diabetic history of the patient, including physiologic stressors and exogenous glucose administration.Reference Russo 24 Although we were able to assess the confounding effect of body mass index and found no effect on our conclusions, our ability to fully assess potential confounders in the current meta-analysis is limited by the variables assessed in the original studies. However, the most adjusted estimate from each study was used in the final analysis, which should benefit from control of other confounding variables at the individual study level. Our findings point to several directions for future research. Few studies have assessed whether a more detailed assessment of diabetes severity would improve the management of SSI risk in these patients. Secondly, few studies address the cause of the infection, and thus we are unable to rule out whether the increased risk of SSI among diabetics is related to differences in bacterial etiology.

Overall, these results support the consideration of diabetes as an independent risk factor for SSIs for multiple procedure types and continued efforts are needed to improve surgical outcomes for diabetic patients.

ACKNOWLEDGMENTS

Financial support. This work was supported by the National Institutes of Health (grant no. K01AI099006 to E.T.M.).

Potential conflicts of interest. All authors report no conflicts of interest relevant to this article.

SUPPLEMENTARY MATERIAL

To view supplementary material for this article, please visit http://dx.doi.org/10.1017/ice.2015.249

APPENDIX TABLE 1 Articles Included in 3 Meta-analyses of Diabetes and Pre- and Postoperative Hyperglycemia

Footnotes

PREVIOUS PRESENTATION. We presented these findings in part at the 2014 American Diabetes Association annual meeting in San Francisco, California (June 13–17, 2014), and the 2014 Society for Epidemiology Research conference in Seattle, Washington (June 24–27, 2014).

References

REFERENCES

1. Cheng, YJ, Imperatore, G, Geiss, LS, Wang, J, Saydah, SH, Cowie, CC, et al. Secular changes in the age-specific prevalence of diabetes among US adults: 1988–2010. Diabetes Care 2013;36:2690–2696.Google Scholar
2. Zimlichman, E, Henderson, D, Tamir, O, Franz, C, Song, P, Yamin, CK, et al. Health care-associated infections: a meta-analysis of costs and financial impact on the US health care system. JAMA Intern Med 2013;173:2039–2046.CrossRefGoogle ScholarPubMed
3. Joynt, KE, Jha, AK. Characteristics of hospitals receiving penalties under the Hospital Readmissions Reduction Program. JAMA 2013;309:342–343.Google Scholar
4. Sievert, DM, Ricks, P, Edwards, JR, Schneider, A, Patel, J, Srinivasan, A, et al. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009–2010. Infect Control Hospital Epidemiol 2013;34:1–14.Google Scholar
5. Stroup, DF, Berlin, JA, Morton, SC, Olkin, I, Williamson, GD, Rennie, D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;283:2008–2012.CrossRefGoogle ScholarPubMed
6. Petitti, DB. Meta-analysis, decision analysis, and cost-effectiveness analysis: methods for quantitative synthesis in medicine. 2nd ed. New York: Oxford University Press; 2000. x, 306 p.Google Scholar
7. Higgins, JPT, Green, S, Cochrane Collaboration. Cochrane handbook for systematic reviews of interventions. Chichester, England; Hoboken, NJ: Wiley-Blackwell; 2008. xxi, 649 p.CrossRefGoogle Scholar
8. Latham, R, Lancaster, AD, Covington, JF, Pirolo, JS, Thomas, CS Jr., The association of diabetes and glucose control with surgical-site infections among cardiothoracic surgery patients. Infect Control Hospital Epidemiol 2001;22:607–612.CrossRefGoogle ScholarPubMed
9. Liang, MK, Li, LT, Avellaneda, A, Moffett, JM, Hicks, SC, Awad, SS. Outcomes and predictors of incisional surgical site infection in stoma reversal. JAMA Surg 2013;148:183–189.Google Scholar
10. Olsen, MA, Nepple, JJ, Riew, KD, Lenke, LG, Bridwell, KH, Mayfield, J, et al. Risk factors for surgical site infection following orthopaedic spinal operations. J Bone Joint Surg Am 2008;90:62–69.CrossRefGoogle ScholarPubMed
11. Wilson, SJ, Sexton, DJ. Elevated preoperative fasting serum glucose levels increase the risk of postoperative mediastinitis in patients undergoing open heart surgery. Infect Control Hospital Epidemiol 2003;24:776–778.CrossRefGoogle ScholarPubMed
12. Lazar, HL, McDonnell, M, Chipkin, SR, Furnary, AP, Engelman, RM, Sadhu, AR, et al. The Society of Thoracic Surgeons practice guideline series: Blood glucose management during adult cardiac surgery. Ann Thorac Surg 2009;87:663–669.CrossRefGoogle Scholar
13. American Diabetes A. Standards of medical care in diabetes—2008. Diabetes Care 2008;31:S12–S54.CrossRefGoogle Scholar
14. Mu, Y, Edwards, JR, Horan, TC, Berrios-Torres, SI, Fridkin, SK. Improving risk-adjusted measures of surgical site infection for the national healthcare safety network. Infect Control Hospital Epidemiol 2011;32:970–986.Google Scholar
15. Sehgal, R, Berg, A, Figueroa, R, Poritz, LS, McKenna, KJ, Stewart, DB, et al. Risk factors for surgical site infections after colorectal resection in diabetic patients. J Am Coll Surg 2011;212:29–34.CrossRefGoogle ScholarPubMed
16. Friedman, ND, Sexton, DJ, Connelly, SM, Kaye, KS. Risk factors for surgical site infection complicating laminectomy. Infect Control Hospital Epidemiol 2007;28:1060–1065.CrossRefGoogle ScholarPubMed
17. Caputo, AM, Dobbertien, RP, Ferranti, JM, Brown, CR, Michael, KW, Richardson, WJ. Risk factors for infection after orthopaedic spine surgery at a high-volume institution. J Surg Orthopaed Adv 2013;22:295–298.Google Scholar
18. Furnary, AP, Zerr, KJ, Grunkemeier, GL, Starr, A. Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures. Ann Thorac Surg 1999;67:352–360; discussion 60–62.Google Scholar
19. Zerr, KJ, Furnary, AP, Grunkemeier, GL, Bookin, S, Kanhere, V, Starr, A. Glucose control lowers the risk of wound infection in diabetics after open heart operations. Ann Thorac Surg 1997;63:356–361.CrossRefGoogle ScholarPubMed
20. Kwon, S, Thompson, R, Dellinger, P, Yanez, D, Farrohki, E, Flum, D. Importance of perioperative glycemic control in general surgery: a report from the Surgical Care and Outcomes Assessment Program. Ann Surg 2013;257:8–14.Google Scholar
21. Hardy, SJ, Nowacki, AS, Bertin, M, Weil, RJ. Absence of an association between glucose levels and surgical site infections in patients undergoing craniotomies for brain tumors. J Neurosurg 2010;113:161–166.CrossRefGoogle ScholarPubMed
22. Jeon, CY, Furuya, EY, Berman, MF, Larson, EL. The role of pre-operative and post-operative glucose control in surgical-site infections and mortality. PloS One 2012;7:e45616.Google Scholar
23. Trussell, J, Gerkin, R, Coates, B, Brandenberger, J, Tibi, P, Keuth, J, et al. Impact of a patient care pathway protocol on surgical site infection rates in cardiothoracic surgery patients. Am J Surg 2008;196:883–889; discussion 9.Google Scholar
24. Russo, N. Perioperative glycemic control. Anesthesiol Clin 2012;30:445–466.CrossRefGoogle ScholarPubMed
25. Abdul-Jabbar, A, Takemoto, S, Weber, MH, Hu, SS, Mummaneni, PV, Deviren, V, et al. Surgical site infection in spinal surgery: description of surgical and patient-based risk factors for postoperative infection using administrative claims data. Spine 2012;37:1340–1345.CrossRefGoogle ScholarPubMed
26. Anaya, DA, Cormier, JN, Xing, Y, Koller, P, Gaido, L, Hadfield, D, et al. Development and validation of a novel stratification tool for identifying cancer patients at increased risk of surgical site infection. Ann Surg 2012;255:134–139.Google Scholar
27. Anthony, T, Murray, BW, Sum-Ping, JT, Lenkovsky, F, Vornik, VD, Parker, BJ, et al. Evaluating an evidence-based bundle for preventing surgical site infection: a randomized trial. Arch Surg 2011;146:263–269.CrossRefGoogle ScholarPubMed
28. Apisarnthanarak, A, Jones, M, Waterman, BM, Carroll, CM, Bernardi, R, Fraser, VJ. Risk factors for spinal surgical-site infections in a community hospital: a case-control study. Infect Control Hospital Epidemiol 2003;24:31–36.Google Scholar
29. Bachoura, A, Guitton, TG, Smith, RM, Vrahas, MS, Zurakowski, D, Ring, D. Infirmity and injury complexity are risk factors for surgical-site infection after operative fracture care. Clin Orthopaed Rel Res 2011;469:2621–2630.Google Scholar
30. Bertin, ML, Crowe, J, Gordon, SM. Determinants of surgical site infection after breast surgery. Am J Infect Control 1998;26:61–65.Google Scholar
31. Boston, KM, Baraniuk, S, O’Heron, S, Murray, KO. Risk factors for spinal surgical site infection, Houston, Texas. Infect Control Hospital Epidemiol 2009;30:884–889.CrossRefGoogle ScholarPubMed
32. Bundy, JK, Gonzalez, VR, Barnard, BM, Hardy, RJ, DuPont, HL. Gender risk differences for surgical site infections among a primary coronary artery bypass graft surgery cohort: 1995–1998. Am J Infect Control 2006;34:114–121.CrossRefGoogle ScholarPubMed
33. Bykowski, MR, Sivak, WN, Cray, J, Buterbaugh, G, Imbriglia, JE, Lee, WP. Assessing the impact of antibiotic prophylaxis in outpatient elective hand surgery: a single-center, retrospective review of 8,850 cases. J Hand Surg 2011;36:1741–1747.CrossRefGoogle Scholar
34. Cannon, JA, Altom, LK, Deierhoi, RJ, Morris, M, Richman, JS, Vick, CC, et al. Preoperative oral antibiotics reduce surgical site infection following elective colorectal resections. Dis Colon Rectum 2012;55:1160–1166.CrossRefGoogle ScholarPubMed
35. Chaichana, KL, Kone, L, Bettegowda, C, Weingart, JD, Olivi, A, Lim, M, et al. Risk of surgical site infection in 401 consecutive patients with glioblastoma with and without carmustine wafer implantation. Neurol Res 2015;37:717–726.CrossRefGoogle ScholarPubMed
36. Chapman, JS, Roddy, E, Westhoff, G, Simons, E, Brooks, R, Ueda, S, et al. Post-operative enteral immunonutrition for gynecologic oncology patients undergoing laparotomy decreases wound complications. Gynecol Oncol 2015;137:523–528.CrossRefGoogle ScholarPubMed
37. Chen, S, Anderson, MV, Cheng, WK, Wongworawat, MD. Diabetes associated with increased surgical site infections in spinal arthrodesis. Clin OrthopaedRel Res 2009;467:1670–1673.CrossRefGoogle ScholarPubMed
38. Chen, TY, Anderson, DJ, Chopra, T, Choi, Y, Schmader, KE, Kaye, KS. Poor functional status is an independent predictor of surgical site infections due to methicillin-resistant Staphylococcus aureus in older adults. J Am Geriatr Soc 2010;58:527–532.Google Scholar
39. Chiang, HY, Kamath, AS, Pottinger, JM, Greenlee, JDW, Howard, IMA, Cavanaugh, JE, et al. Risk factors and outcomes associated with surgical site infections after craniotomy or craniectomy clinical article. J Neurosurg 2014;120:509–521.CrossRefGoogle ScholarPubMed
40. Chopra, T, Marchaim, D, Lynch, Y, Kosmidis, C, Zhao, JJ, Dhar, S, et al. Epidemiology and outcomes associated with surgical site infection following bariatric surgery. Am J Infect Control 2012;40:815–819.Google Scholar
41. Chu, DI, Schlieve, CR, Colibaseanu, DT, Simpson, PJ, Wagie, AE, Cima, RR, et al. Surgical site infections (SSIs) after stoma reversal (SR): risk factors, implications, and protective strategies. J Gastrointest Surg Tract 2015;19:327–334.Google Scholar
42. Chung, CU, Wink, JD, Nelson, JA, Fischer, JP, Serletti, JM, Kanchwala, SK. Surgical site infections after free flap breast reconstruction: an analysis of 2,899 patients from the ACS-NSQIP datasets. J Reconstruct Microsurg 2015;31:434–441.Google Scholar
43. Coakley, BA, Divino, CM. Identifying factors predictive of surgical-site infections after colectomy for fulminant ulcerative colitis. Am Surgeon 2012;78:481–484.CrossRefGoogle ScholarPubMed
44. Coleman, JS, Green, I, Scheib, S, Sewell, C, Lee, JM, Anderson, J. Surgical site infections after hysterectomy among HIV-infected women in the HAART era: a single institution’s experience from 1999–2012. Am J Obstet Gynecol 2014;210:117.e1–117.e7.CrossRefGoogle Scholar
45. Davies, SW, Turza, KC, Sawyer, RG, Schirmer, BD, Hallowell, PT. A comparative analysis between laparoscopic and open ventral hernia repair at a tertiary care center. Am Surgeon 2012;78:888–892.Google Scholar
46. deFreitas, DJ, Kasirajan, K, Ricotta, JJ 2nd, Veeraswamy, RK, Corriere, MA. Preoperative inpatient hospitalization and risk of perioperative infection following elective vascular procedures. Ann Vasc Surg 2012;26:46–54.Google Scholar
47. Deierhoi, RJ, Dawes, LG, Vick, C, Itani, KMF, Hawn, MT. Choice of intravenous antibiotic prophylaxis for colorectal surgery does matter. J Am Coll Surg 2013;217:763–769.CrossRefGoogle ScholarPubMed
48. Elfenbein, DM, Schneider, DF, Chen, H, Sippel, RS. Surgical site infection after thyroidectomy: a rare but significant complication. J Surg Res 2014;190:170–176.Google Scholar
49. Everhart, JS, Altneu, E, Calhoun, JH. Medical comorbidities are independent preoperative risk factors for surgical infection after total joint arthroplasty. Clin Orthopaed Rel Res 2013;471:3112–3119.CrossRefGoogle ScholarPubMed
50. Fakih, MG, Sharma, M, Khatib, R, Berriel-Cass, D, Meisner, S, Harrington, S, et al. Increase in the rate of sternal surgical site infection after coronary artery bypass graft: a marker of higher severity of illness. Infect Control Hospital Epidemiol 2007;28:655–660.Google Scholar
51. Farrow, B, Awad, S, Berger, DH, Albo, D, Lee, L, Subramanian, A, et al. More than 150 consecutive open umbilical hernia repairs in a major Veterans Administration Medical Center. Am J Surg 2008;196:647–651.CrossRefGoogle Scholar
52. Fowler, VG Jr., O’Brien, SM, Muhlbaier, LH, Corey, GR, Ferguson, TB, Peterson, ED. Clinical predictors of major infections after cardiac surgery. Circulation 2005;112:I358–I365.CrossRefGoogle ScholarPubMed
53. George, AK, Srinivasan, AK, Cho, J, Sadek, MA, Kavoussi, LR. Surgical site infection rates following laparoscopic urological procedures. J Urol 2011;185:1289–1293.CrossRefGoogle ScholarPubMed
54. Haas, JP, Evans, AM, Preston, KE, Larson, EL. Risk factors for surgical site infection after cardiac surgery: the role of endogenous flora. Heart Lung 2005;34:108–114.CrossRefGoogle ScholarPubMed
55. Haley, VB, Van Antwerpen, C, Tsivitis, M, Doughty, D, Gase, KA, Hazamy, P, et al. Risk factors for coronary artery bypass graft chest surgical site infections in New York State, 2008. Am J Infect Control 2012;40:22–28.Google Scholar
56. Harbarth, S, Samore, MH, Lichtenberg, D, Carmeli, Y. Prolonged antibiotic prophylaxis after cardiovascular surgery and its effect on surgical site infections and antimicrobial resistance. Circulation 2000;101:2916–2921.Google Scholar
57. Harness, NG, Inacio, MC, Pfeil, FF, Paxton, LW. Rate of infection after carpal tunnel release surgery and effect of antibiotic prophylaxis. J Hand Surg 2010;35:189–196.CrossRefGoogle ScholarPubMed
58. Hellinger, WC, Heckman, MG, Crook, JE, Taner, CB, Willingham, DL, Diehl, NN, et al. Association of surgeon with surgical site infection after liver transplantation. Am J Transplant 2011;11:1877–1884.Google Scholar
59. Hendren, S, Fritze, D, Banerjee, M, Kubus, J, Cleary, RK, Englesbe, MJ, et al. Antibiotic choice is independently associated with risk of surgical site infection after colectomy: a population-based cohort study. Ann Surg 2013;257:469–475.CrossRefGoogle ScholarPubMed
60. Jackson, RS, Amdur, RL, White, JC, Macsata, RA. Hyperglycemia is associated with increased risk of morbidity and mortality after colectomy for cancer. J Am Coll Surg 2012;214:68–80.Google Scholar
61. Kaafarani, HMA, Kaufman, D, Reda, D, Itani, KMF. Predictors of surgical site infection in laparoscopic and open ventral incisional herniorrhaphy. J Surg Res 2010;163:229–234.Google Scholar
62. Kalra, L, Camacho, F, Whitener, CJ, Du, P, Miller, M, Zalonis, C, et al. Risk of methicillin-resistant Staphylococcus aureus surgical site infection in patients with nasal MRSA colonization. Am J Infect Control 2013;41:1253–1257.CrossRefGoogle ScholarPubMed
63. Koutsoumbelis, S, Hughes, AP, Girardi, FP, Cammisa, FP Jr., Finerty, EA, Nguyen, JT, et al. Risk factors for postoperative infection following posterior lumbar instrumented arthrodesis. J Bone Joint Surg Am 2011;93:1627–1633.CrossRefGoogle ScholarPubMed
64. Kuy, S, Dua, A, Desai, S, Dua, A, Patel, B, Tondravi, N, et al. Surgical site infections after lower extremity revascularization procedures involving groin incisions. Ann Vasc Surg 2014;28:53–58.Google Scholar
65. Lim, S, Edelstein, AI, Patel, AA, Kim, BD, Kim, JY. Risk factors for postoperative infections following single level lumbar fusion surgery. Spi ne 2014 [Epub ahead of print].Google Scholar
66. Liu, DZ, Dubbins, JA, Louie, O, Said, HK, Neligan, PC, Mathes, DW. Duration of antibiotics after microsurgical breast reconstruction does not change surgical infection rate. Plastic Reconstr Surg 2012;129:362–367.Google Scholar
67. Lovecchio, F, Beal, M, Kwasny, M, Manning, D. Do patients with insulin-dependent and noninsulin-dependent diabetes have different risks for complications after arthroplasty? Clin Orthopaed Rel Res 2014;472:3570–3575.Google Scholar
68. Lynch, RJ, Ranney, DN, Shijie, C, Lee, DS, Samala, N, Englesbe, MJ. Obesity, surgical site infection, and outcome following renal transplantation. Ann Surg 2009;250:1014–1020.Google Scholar
69. Mahajan, SN, Ariza-Heredia, EJ, Rolston, KV, Graviss, LS, Feig, BW, Aloia, TA, et al. Perioperative antimicrobial prophylaxis for intra-abdominal surgery in patients with cancer: a retrospective study comparing ertapenem and nonertapenem antibiotics. Ann Surg Oncol 2014;21:513–519.Google Scholar
70. Mahdi, H, Gojayev, A, Buechel, M, Knight, J, SanMarco, J, Lockhart, D, et al. Surgical site infection in women undergoing surgery for gynecologic cancer. Int J Gynecol Cancer 2014;24:779–786.Google Scholar
71. Maragakis, LL, Cosgrove, SE, Martinez, EA, Tucker, MG, Cohen, DB, Perl, TM. Intraoperative fraction of inspired oxygen is a modifiable risk factor for surgical site infection after spinal surgery. Anesthesiology 2009;110:556–562.CrossRefGoogle ScholarPubMed
72. Marschall, J, Hopkins-Broyles, D, Jones, M, Fraser, VJ, Warren, DK. Case-control study of surgical site infections associated with pacemakers and implantable cardioverter-defibrillators. Infect Control Hospital Epidemiol 2007;28:1299–1304.Google Scholar
73. Mehta, AI, Babu, R, Karikari, IO, Grunch, B, Agarwal, VJ, Owens, TR, et al. 2012 Young Investigator Award winner: the distribution of body mass as a significant risk factor for lumbar spinal fusion postoperative infections. Spine 2012;37:1652–1656.Google Scholar
74. Mehta, AI, Babu, R, Sharma, R, Karikari, IO, Grunch, BH, Owens, TR, et al. Thickness of subcutaneous fat as a risk factor for infection in cervical spine fusion surgery. J Bone Joint Surg Am 2013;95:323–328.CrossRefGoogle ScholarPubMed
75. Miransky, J, Ruo, L, Nicoletta, S, Eagan, J, Sepkowitz, K, Margetson, N, et al. Impact of a surgeon-trained observer on accuracy of colorectal surgical site infection rates. Dis Colon Rectum 2001;44:1100–1105.Google Scholar
76. Namba, RS, Inacio, MC, Paxton, EW. Risk factors associated with surgical site infection in 30,491 primary total hip replacements. J Bone Joint Surg Brit 2012;94:1330–1338.Google Scholar
77. Namba, RS, Inacio, MC, Paxton, EW. Risk factors associated with deep surgical site infections after primary total knee arthroplasty: an analysis of 56,216 knees. J Bone Joint Surg Am 2013;95:775–782.Google Scholar
78. Nash, MC, Strom, JA, Pathak, EB. Prevalence of major infections and adverse outcomes among hospitalized. ST-elevation myocardial infarction patients in Florida, 2006. BMC Cardiovasc Disord 2011;11:69.Google Scholar
79. Neumayer, L, Hosokawa, P, Itani, K, El-Tamer, M, Henderson, WG, Khuri, SF. Multivariable predictors of postoperative surgical site infection after general and vascular surgery: results from the patient safety in surgery study. J Am Coll Surg 2007;204:1178–1187.CrossRefGoogle ScholarPubMed
80. Nguyen, TJ, Costa, MA, Vidar, EN, Shahabi, A, Peric, M, Hernandez, AM, et al. Effect of immediate reconstruction on postmastectomy surgical site infection. Ann Surg 2012;256:326–333.Google Scholar
81. Olsen, MA, Lock-Buckley, P, Hopkins, D, Polish, LB, Sundt, TM, Fraser, VJ. The risk factors for deep and superficial chest surgical-site infections after coronary artery bypass graft surgery are different. J Thorac Cardiovasc Surg 2002;124:136–145.Google Scholar
82. Olsen, MA, Lefta, M, Dietz, JR, Brandt, KE, Aft, R, Matthews, R, et al. Risk factors for surgical site infection after major breast operation. J Am Coll Surg 2008;207:326–335.Google Scholar
83. Olsen, MA, Butler, AM, Willers, DM, Devkota, P, Gross, GA, Fraser, VJ. Risk factors for surgical site infection after low transverse cesarean section. Infect Control Hospital Epidemiol 2008;29:477–484; discussion 485–486.CrossRefGoogle ScholarPubMed
84. Olsen, MA, Higham-Kessler, J, Yokoe, DS, Butler, AM, Vostok, J, Stevenson, KB, et al. Developing a risk stratification model for surgical site infection after abdominal hysterectomy. Infect Control Hospital Epidemiol 2009;30:1077–1083.Google Scholar
85. Park, C, Hsu, C, Neelakanta, G, Nourmand, H, Braunfeld, M, Wray, C, et al. Severe intraoperative hyperglycemia is independently associated with surgical site infection after liver transplantation. Transplantation 2009;87:1031–1036.Google Scholar
86. Paryavi, E, Stall, A, Gupta, R, Scharfstein, DO, Castillo, RC, Zadnik, M, et al. Predictive model for surgical site infection risk after surgery for high-energy lower-extremity fractures: development of the risk of infection in orthopedic trauma surgery score. J Trauma Acute Care Surg 2013;74:1521–1527.CrossRefGoogle ScholarPubMed
87. Pastor, C, Baek, JH, Varma, MG, Kim, E, Indorf, LA, Garcia-Aguilar, J. Validation of the risk index category as a predictor of surgical site infection in elective colorectal surgery. Dis Colon Rectum 2010;53:721–727.CrossRefGoogle ScholarPubMed
88. Ponce, B, Raines, BT, Reed, RD, Vick, C, Richman, J, Hawn, M. Surgical site infection after arthroplasty: comparative effectiveness of prophylactic antibiotics: do surgical care improvement project guidelines need to be updated? J Bone Joint Surg Am 2014;96:970–977.Google Scholar
89. Rao, SB, Vasquez, G, Harrop, J, Maltenfort, M, Stein, N, Kaliyadan, G, et al. Risk factors for surgical site infections following spinal fusion procedures: a case-control study. Clin Infect Dis 2011;53:686–692.CrossRefGoogle ScholarPubMed
90. Saleh, K, Olson, M, Resig, S, Bershadsky, B, Kuskowski, M, Gioe, T, et al. Predictors of wound infection in hip and knee joint replacement: results from a 20-year surveillance program. J Orthopaed Res 2002;20:506–515.Google Scholar
91. Segal, CG, Waller, DK, Tilley, B, Piller, L, Bilimoria, K. An evaluation of differences in risk factors for individual types of surgical site infections after colon surgery. Surgery 2014;156:1253–1260.CrossRefGoogle ScholarPubMed
92. Senekjian, L, Nirula, R. Tailoring the operative approach for appendicitis to the patient: a prediction model from national surgical quality improvement program data. J Am Coll Surg 2013;216:34–40.Google Scholar
93. Sharma, M, Fakih, MG, Berriel-Cass, D, Meisner, S, Saravolatz, L, Khatib, R. Harvest surgical site infection following coronary artery bypass grafting: risk factors, microbiology, and outcomes. Am J Infect Control 2009;37:653–657.CrossRefGoogle ScholarPubMed
94. Shields, RK, Clancy, CJ, Minces, LR, Shigemura, N, Kwak, EJ, Silveira, FP, et al. Epidemiology and outcomes of deep surgical site infections following lung transplantation. Am J Transplant 2013;13:2137–2145.CrossRefGoogle ScholarPubMed
95. Shuman, AG, Shuman, EK, Hauff, SJ, Fernandes, LL, Light, E, Chenoweth, CE, et al. Preoperative topical antimicrobial decolonization in head and neck surgery. Laryngoscope 2012;122:2454–2460.CrossRefGoogle ScholarPubMed
96. Singh, R, Mesh, CL, Aryaie, A, Dwivedi, AK, Marsden, B, Shukla, R, et al. Benefit of a single dose of preoperative antibiotic on surgical site infection in varicose vein surgery. Ann Vasc Surg 2012;26:612–619.Google Scholar
97. Smith, RL, Bohl, JK, McElearney, ST, Friel, CM, Barclay, MM, Sawyer, RG, et al. Wound infection after elective colorectal resection. Ann Surg 2004;239:599–605.Google Scholar
98. Spaniolas, K, Kasten, KR, Mozer, AB, Sippey, ME, Chapman, WH, Pories, WJ, et al. Synchronous ventral hernia repair in patients undergoing bariatric surgery. Obes Surg 2015;25:1864–1868.CrossRefGoogle ScholarPubMed
99. Suzuki, T, Morgan, SJ, Smith, WR, Stahel, PF, Gillani, SA, Hak, DJ. Postoperative surgical site infection following acetabular fracture fixation. Injury 2010;41:396–399.CrossRefGoogle ScholarPubMed
100. Talbot, TR, D’Agata, EM, Brinsko, V, Lee, B, Speroff, T, Schaffner, W. Perioperative blood transfusion is predictive of poststernotomy surgical site infection: marker for morbidity or true immunosuppressant? Clin Infect Dis 2004;38:1378–1382.Google Scholar
101. Tomov, M, Mitsunaga, L, Durbin-Johnson, B, Nallur, D, Roberto, R. Reducing surgical site infection in spinal surgery with betadine irrigation and intrawound vancomycin powder. Spine 2015;40:491–499.CrossRefGoogle ScholarPubMed
102. Townsend, TR, Reitz, BA, Bilker, WB, Bartlett, JG. Clinical trial of cefamandole, cefazolin, and cefuroxime for antibiotic prophylaxis in cardiac operations. J Thorac Cardiovasc Surg 1993;106:664–670.Google Scholar
103. Trick, WE, Scheckler, WE, Tokars, JI, Jones, KC, Smith, EM, Reppen, ML, et al. Risk factors for radial artery harvest site infection following coronary artery bypass graft surgery. Clin Infect Dis 2000;30:270–275.Google Scholar
104. Trinh, JV, Chen, LF, Sexton, DJ, Anderson, DJ. Risk factors for gram-negative bacterial surgical site infection: do allergies to antibiotics increase risk? Infect Control Hospital Epidemiol 2009;30:440–446.Google Scholar
105. Tserenpuntsag, B, Haley, V, Van Antwerpen, C, Doughty, D, Gase, KA, Hazamy, PA, et al. Surgical site infection risk factors identified for patients undergoing colon procedures, New York State 2009–2010. Infect Control Hospital Epidemiol 2014;35:1006–1012.Google Scholar
106. Walcott, BP, Neal, JB, Sheth, SA, Kahle, KT, Eskandar, EN, Coumans, JV, et al. The incidence of complications in elective cranial neurosurgery associated with dural closure material. J Neurosurg 2014;120:278–284.Google Scholar
107. Woods, BI, Rosario, BL, Chen, A, Waters, JH, Donaldson, W 3rd, Kang, J, et al. The association between perioperative allogeneic transfusion volume and postoperative infection in patients following lumbar spine surgery. J Bone Joint Surg Am 2013;95:2105–2110.Google Scholar
108. Wooldridge, AN, Kolovich, GP, Crist, MK, Mayerson, JL, Scharschmidt, TJ. Predictors of local recurrence in high-grade soft tissue sarcomas: hydrogen peroxide as a local adjuvant. Orthopedics 2013;36:e207–e215.Google Scholar
109. Young, B, Ng, TM, Teng, C, Ang, B, Tai, HY, Lye, DC. Nonconcordance with surgical site infection prevention guidelines and rates of surgical site infections for general surgical, neurological, and orthopedic procedures. Antimicrob Agents Chemother 2011;55:4659–4663.Google Scholar
Figure 0

FIGURE 1 Flow diagram of search and selection processes.

Figure 1

FIGURE 2 Meta-analysis of diabetes and surgical site infection, by surgery type.

Figure 2

TABLE 1 Pooled Estimates of the Association between Diabetes and Surgical Site Infection by Surgery Type

Figure 3

FIGURE 3 Meta-analysis of pre-operative hyperglycemia and surgical site infection.

Figure 4

FIGURE 4 Meta-analysis of post-operative hyperglycemia and surgical site infection.

Figure 5

APPENDIX TABLE 1 Articles Included in 3 Meta-analyses of Diabetes and Pre- and Postoperative Hyperglycemia

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