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Risk Factors for Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae in a Neonatal Intensive Care Unit

Published online by Cambridge University Press:  02 January 2015

Darren R. Linkin ,
Neil O. Fishman ,
Jean Baldus Patel ,
Jeffrey D. Merrill  and
Ebbing Lautenbach
Darren R. Linkin*
Affiliation:
Department of Medicine, Division of Infectious Diseases, Center for Education and Research on Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania
Neil O. Fishman
Affiliation:
Department of Medicine, Division of Infectious Diseases, Center for Education and Research on Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania
Jean Baldus Patel
Affiliation:
Epidemiology and Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia
Jeffrey D. Merrill
Affiliation:
Division of Neonatology, Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania
Ebbing Lautenbach
Affiliation:
Department of Medicine, Division of Infectious Diseases, Center for Education and Research on Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania
*
Division of Infectious Diseases, University of Pennsylvania, 502 Johnson Pavilion, MC 6073, Philadelphia, PA 19104
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Abstract

Risk factors for colonization or infection with extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae during an outbreak in a neonatal intensive care unit (NICU) included low gestational age and exposure to third-generation cephalosporins. We also reviewed the existing medical literature regarding the clinical epidemiology of ESBLs in NICUs.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 25 , Issue 9 , September 2004 , pp. 781 - 783
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2004

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References

1.Jacoby, GA. Extended-spectrum beta-lactamases and other enzymes providing resistance to oxyimino-beta-lactams. Infect Dis Clin North Am 1997;11:875–887.CrossRefGoogle ScholarPubMed
2.Paterson, DL, Ko, WC, Mohapatra, S, et al.Klebsiella pneumoniae bacteremia: impact of extended-spectrum B-lactamase (ESBL) production in a global study of 216 patients. Presented at the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 28-October 1, 1997; Toronto, Ontario, Canada.Google Scholar
3.Lautenbach, E, Patel, JB, Bilker, WB, Edelstein, PH, Fishman, NO. Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for infection and impact of resistance on outcomes. Clin Infect Dis 2001;32:1162–1171.CrossRefGoogle ScholarPubMed
4.Safdar, N, Maki, DG. The commonality of risk factors for nosocomial colonization and infection with antimicrobial-resistant Staphylococcus aureus, enterococcus, gram-negative bacilli, Clostridium difficile, and Candida. Ann Intern Med 2002;136:834–844.CrossRefGoogle ScholarPubMed
5.Royle, J, Halasz, S, Eagles, G, et al.Outbreak of extended spectrum beta lactamase producing Klebsiella pneumoniae in a neonatal unit. Arch Dis Child Fetal Neonatal Ed 1999;80:F64–F68.CrossRefGoogle Scholar
6.Martinez-Aguilar, G, Alpuche-Aranda, CM, Anaya, C, et al.Outbreak of nosocomial sepsis and pneumonia in a newborn intensive care unit by multiresistant extended-spectrum beta-lactamase-producing Klebsiella pneumoniae: high impact on mortality. Infect Control Hosp Epidemiol 2001;22:725–728.CrossRefGoogle Scholar
7.Venezia, RA, Scarano, FJ, Preston, KE, et al.Molecular epidemiology of an SHV-5 extended-spectrum beta-lactamase in enterobacteriaceae isolated from infants in a neonatal intensive care unit. Clin Infect Dis 1995;21:915–923.CrossRefGoogle Scholar
8.Bisson, G, Fishman, NO, Patel, JB, Edelstein, PH, Lautenbach, E. Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species: risk factors for colonization and impact of antimicrobial formulary interventions on colonization prevalence. Infect Control Hosp Epidemiol 2002;23:254–260.CrossRefGoogle ScholarPubMed
9.Pessoa-Silva, CL, Toscano, CM, Moreira, BM, et al.Infection due to extended-spectrum beta-lactamase-producing Salmonella enterica subsp. enterica serotype infantis in a neonatal unit. J Pediatr 2002;141:381–387.CrossRefGoogle Scholar
10.Pessoa-Silva, CL, Meurer Moreira, B, Camara Almeida, V, et al.Extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit: risk factors for infection and colonization. J Hosp Infect 2003;53:198–206.CrossRefGoogle Scholar
11.Harris, AD, Karchmer, TB, Carmeli, Y, Samore, MH. Methodological principles of case-control studies that analyzed risk factors for antibiotic resistance: a systematic review. Clin Infect Dis 2001;32:1055–1061.CrossRefGoogle ScholarPubMed