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Health technology assessment in the era of personalized health care

Published online by Cambridge University Press:  30 March 2011

Lidia Becla ,
Jeantine E. Lunshof ,
David Gurwitz ,
Tobias Schulte in den Bäumen ,
Hans V. Westerhoff ,
Bodo M. H. Lange  and
Angela Brand
Lidia Becla
Affiliation:
Maastricht University and Agency for Health Technology Assessment in Poland (AHTAPol)
Jeantine E. Lunshof
Affiliation:
Maastricht University and VU University Amsterdam
David Gurwitz
Affiliation:
Sackler Faculty of Medicine
Tobias Schulte in den Bäumen
Affiliation:
Maastricht University
Hans V. Westerhoff
Affiliation:
VU University Amsterdam; Netherlands Institute for Systems Biology; University of Manchester; and Manchester Interdisciplinary BioCentre
Bodo M. H. Lange
Affiliation:
FU Berlin and Max Planck Institute for Molecular Genetics
Angela Brand
Affiliation:
Maastricht University
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Abstract

Objectives: This article examines the challenges for health technology assessment (HTA) in the light of new developments of personalized health care, focusing on European HTA perspectives.

Methods: Using the example of the Integrated Genome Research Network – Mutanom (IG Mutanom) project, with focus on personalized cancer diagnostics and treatment, we assess the scope of current HTA and examine it prospectively in the context of the translation of basic and clinical research into public health genomics and personalized health care.

Results: The approaches developed within the IG-Mutanom project are based on innovative technology potentially providing targeted therapies for cancer; making translation into clinical practice requires a novel course of action, however. New models of HTA are needed that can account for the unique types of evidence inherent to individualized targeted therapies. Using constructive health technology assessment (CTA) models is an option, but further suitable models should be developed.

Conclusions: Integrative, systems biology-based approaches toward personalized medicine call for novel assessment methods. The translation of their highly innovative technologies into the practice of health care requires the development of new HTA concepts.

Keywords

Health technology assessmentPersonalized cancer therapyPublic health genomicsSystems biologyMutanom
Type
METHODS
Information
International Journal of Technology Assessment in Health Care , Volume 27 , Issue 2 , April 2011 , pp. 118 - 126
Copyright
Copyright © Cambridge University Press 2011

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