When the idea for this special number of International Organization first took shape, the theme was a rather general one, “asymmetric international relations.” I had hoped to encourage contributions from the areas of small state and client state behavior, dominance and dependence, imperialism, and great power—small power behavior. While all of these phenomena are tied together by a shared asymmetric property, this is a “bland common denominator” on which to launch a collection of articles. As the enterprise evolved, we decided to develop a clearer focus on dependence and dependency. It became clear that there were two different sets of theoretical concerns before us which were sometimes labeled identically and often treated indiscriminately for analytical purposes. We drew the distinction between dependence as external reliance on other actors and dependency as the process of incorporation of less developed countries (LDCs) into the global capitalist system and the “structural distortions” resulting therefrom. There are similarities between these two approaches. Both have a predominant focus on relational inequalities among actors and both are equally interested in the vulnerabilities of members of the global system resulting from these unequal relations. However, there are important differences too. In addition to basic theoretical differences, there are equally fundamental gaps in the supportive methodologies. The dependence orientation seeks to probe and explore the symmetries and asymmetries among nation-states. This approach most often proceeds from a liberal paradigm which focuses on individual actors and their goals and which sees power in decisional terms. The individual actors are usually internally unified states which confront the external environment as homogeneous units. With the nation-state as the basic unit of analysis, analysis of dependent relations can be carried out on any combination of states, from dyads up to larger groupings. The fact that dependence is a term which can be meaningfully discussed at the dyadic level allows one the luxury of dealing with large numbers of observations. Thus, dependence theory is easily linked to statistical modes of analysis.