Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-19T03:18:03.888Z Has data issue: false hasContentIssue false
  • English
  • Français

The importance of high quality trials of cognitive interventions in Alzheimer's disease

Published online by Cambridge University Press:  01 April 2016

Jonathan Huntley  and
Robert Howard
Jonathan Huntley
Affiliation:
Department of Old Age Psychiatry, King's College London, London, UK
Robert Howard*
Affiliation:
Division of Psychiatry, University College London, London, UK
*
Email: robert.howard@ucl.ac.uk
Get access

Extract

Currently available treatments for Alzheimer's disease (AD) are disappointing and their modest benefits do not reflect the increased understanding of the condition that has arisen from the last 50 years of research or the huge investments made by the pharmaceutical industry and academia in developing therapies. Cholinesterase inhibitors and memantine are evidence-based symptomatic treatments that offer benefits at the margins of clinical significance, but successive failures in trials of putative disease-modifying drugs have led researchers to investigate the potential efficacy of non-drug interventions. Exercise and cognitive-based interventions have received the most attention, but we are still a long way from understanding whether any can offer real benefit to patients with AD (Huntley et al., 2015).

Type
Commentary paper of the month
Information
International Psychogeriatrics , Volume 28 , Issue 5 , May 2016 , pp. 705 - 706
Copyright
Copyright © International Psychogeriatric Association 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bahar-Fuchs, A., Clare, L. and Woods, B. (2013). Cognitive training and cognitive rehabilitation for mild to moderate Alzheimer's disease and vascular dementia. The Cochrane Database of Systematic Reviews, 6, CD003260.Google Scholar
Corbett, A. et al., (2015). The effect of an online cognitive training package in healthy older adults: an online randomized controlled trial. Journal of the American Medical Directors Association, 16, 990–7.Google Scholar
Howard, R. et al., (2015). Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses. The Lancet Neurology, 14, 1171–81.Google Scholar
Huntley, J. D., Gould, R. L., Liu, K., Smith, M. and Howard, R. J. (2015). Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression. BMJ Open, 5, e005247.Google Scholar
Lampit, A., Hallock, H. and Valenzuela, M. (2014). Computerized cognitive training in cognitively healthy older adults: a systematic review and meta-analysis of effect modifiers. PLoS Med, 11, e1001756.Google Scholar