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The association of traumatic brain injury with rate of progression of cognitive and functional impairment in a population-based cohort of Alzheimer's disease: the Cache County Dementia Progression Study*

Published online by Cambridge University Press:  15 May 2014

Mac Gilbert ,
Christine Snyder ,
Chris Corcoran ,
Maria C. Norton ,
Constantine G. Lyketsos  and
JoAnn T. Tschanz
Mac Gilbert
Affiliation:
Department of Psychology, Utah State University, Logan, Utah, USA
Christine Snyder
Affiliation:
Department of Psychology, Utah State University, Logan, Utah, USA
Chris Corcoran
Affiliation:
Department of Mathematics and Statistics, Utah State University, Logan, Utah, USA Center for Epidemiological Studies, Utah State University, Logan, Utah, USA
Maria C. Norton
Affiliation:
Department of Psychology, Utah State University, Logan, Utah, USA Center for Epidemiological Studies, Utah State University, Logan, Utah, USA Department of Family, Consumer, and Human Development, Utah State University, Logan, Utah, USA
Constantine G. Lyketsos
Affiliation:
Department of Psychiatry, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA
JoAnn T. Tschanz*
Affiliation:
Department of Psychology, Utah State University, Logan, Utah, USA Center for Epidemiological Studies, Utah State University, Logan, Utah, USA
*
Correspondence should be addressed to: Dr JoAnn T. Tschanz, PhD, Center for Epidemiologic Studies, Utah State University, 4450 Old Main Hill, Logan 84322-4450, UT, USA. Phone: +1-435-797-1583. Email: joann.tschanz@usu.edu.
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Abstract

Background:

There is limited research on factors that influence the rate of progression in Alzheimer's disease (AD). A history of traumatic brain injury (TBI) is associated with an increased risk for AD, but its role on the rate of dementia progression after the onset of AD has not been examined.

Methods:

A population-based cohort of 325 persons with incident AD was followed for up to 11 years. The sample was 65% female with a mean (SD) age of dementia onset = 84.4 (6.4) years. History of TBI was categorized as number, severity (with or without loss of consciousness), and timing in relation to dementia onset (within ten years or more than ten years). Cognition was assessed by the Consortium to Establish a Registry of AD battery, and functional ability was assessed by the Clinical Dementia Rating Sum of Boxes.

Results:

In linear mixed models, a history of TBI within ten years of onset showed faster progression of functional impairment (LR x2 = 10.27, p = 0.006), while those with TBI more than ten years before dementia onset had higher scores on a measure of list learning (β = 1.61, p = 0.003) and semantic memory (β = 0.75, p = 0.0035).

Conclusions:

History of TBI and its recency may be a useful factor to predict functional progression in the course of AD.

Keywords

traumatic brain injurydementia progressionfunctional abilityAlzheimer's disease
Type
Research Article
Information
International Psychogeriatrics , Volume 26 , Issue 10 , October 2014 , pp. 1593 - 1601
Copyright
Copyright © International Psychogeriatric Association 2014 

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Footnotes

*

Presented in preliminary form at the Alzheimer's Association International Conference in Vancouver, BC, Canada, 2012 and the International Neuropsychological Society Conference in Boston, MA in 2011.

References

Alzheimer's Association. (2013). Alzheimer's disease facts and figures. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 9, 208–245.Google Scholar
American Psychiatric Association. (1987). Diagnostic and Statistical Manual of Mental Disorders, 3rd edn, revised. Washington, DC: American Psychiatric Association.Google Scholar
Amieva, H. et al. (2008). Prodromal Alzheimer's disease: successive emergence of the clinical symptoms. Annals of Neurology, 64, 492–498.Google Scholar
Breitner, J. C. et al. (1999). APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study. Neurology, 53, 321–331.Google Scholar
Coduras, A. et al. (2010). Prospective one-year cost of illness study in a cohort of patients with dementia of Alzheimer's disease type in Spain: the ECO study. Journal of Alzheimers Disease, 19, 601–615. doi:10.3233/JAD-2010-1258.Google Scholar
Graves, A. B. et al. (1990). The association between head trauma and Alzheimer's disease. American Journal of Epidemiology, 131, 491–501.Google Scholar
Guo, Z. et al. (2000). Head injury and the risk fo AD in the MIRAGE study. Neurology, 54, 1316–1323.Google Scholar
Hebert, L. E., Weuve, J., Scherr, P. A. and Evans, D. A. (2013). Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology, 80, 1778–1783. doi:10.1212/WNL.0b013e31828726f5.Google Scholar
Helzner, E. P. et al. (2009). Contribution of vascular risk factors to the progression in Alzheimer disease. Archives of Neurology, 66, 343–348. doi:10.1001/archneur.66.3.343.CrossRefGoogle Scholar
Herrmann, N., Tam, D. Y., Balshaw, R., Sambrook, R., Lesnikova, N. and Lanctot, K. L. (2010). The relation between disease severity and cost of caring for patients with Alzheimer disease in Canada. Canadian Journal of Psychiatry, 55, 768–775.CrossRefGoogle ScholarPubMed
Jellinger, K. A., Paulus, W., Wrocklage, C. and Litvan, I. (2001). Traumatic brain injury as a risk factor for Alzheimer disease. Comparison of two retrospective autopsy cohorts with evaluation of ApoE genotype. BioMed Centeal Neurology, 1, 3.CrossRefGoogle ScholarPubMed
Jorm, A. F. and Jacomb, P. A. (1989). The informant questionnaire on cognitive decline in the elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms. Psychology and Medicine, 19, 1015–1022.Google Scholar
Leoutsakos, J. S. et al. (2012). Effects of general medical health on Alzheimer's progression: the Cache County Dementia Progression Study. International Psychogeriatrics, 24, 1561–1570.CrossRefGoogle ScholarPubMed
Luukinen, H. et al. (2005). Fall-related brain injuries and the risk of dementia in elderly people: a population-based study. European Journal of Neurology, 12, 86–92.Google Scholar
Mayeux, R. et al. (1995). Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease. Neurology, 45, 555–557.Google Scholar
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. and Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology, 34, 939–944.CrossRefGoogle ScholarPubMed
Mielke, M. M. et al. (2011). Interaction between vascular factors and the APOE e4 allele in predicting rate of progression in Alzheimer's disease. Journal of Alzheimers Disease, 26, 127–134. doi:10.3233/JAD-2011-110086.Google Scholar
Mielke, M. M. et al. (2007). Vascular factors predict rate of progression in Alzheimer disease. Neurology, 69, 1850–1858.CrossRefGoogle ScholarPubMed
Morris, J. C. (1993). The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology, 43, 2412–2414.Google Scholar
Morris, J. C., McKeel, D. W. Jr., Fulling, K., Torack, R. M. and Berg, L. (1988). Validation of clinical diagnostic criteria for Alzheimer's disease. Annals of Neurology, 24, 17–22.Google Scholar
Mortimer, J. A. et al. (1991). Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case control studies. EURODEM risk factors research group. International Journal of Epidemiology, 20, S28–S35.Google Scholar
Nakagawa, Y. et al. (1999). Traumatic brain injury in young, amyloid-beta peptide over expressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished Abeta deposition during aging. Journal of Comparative Neurology, 411, 390–398.3.0.CO;2-#>CrossRefGoogle Scholar
Nemetz, P. N. et al. (1999). Traumatic brain injury and time to onset of Alzheimer's disease: a population-based study. American Journal of Epidemiology, 149, 32–40.Google Scholar
Plassman, B. L. et al. (2000). Documented head injury in early adulthood and risk of Alzhereimer's disease and other dementias. Neurology, 55, 1158–1166.Google Scholar
Rao, V. et al. (2010). Neuropsychiatric symptoms in dementia patients with and without a history of traumatic brain injury. Journal of Neuropsychiatry and Clinical Neuroscience, 2, 166–172. doi:10.1176/appi.neuropsych.22.2.166.Google Scholar
Schofield, P. W. et al. (1997). Alzheimer's disease after remote head injury: an incidence study. Journal of Neurology, Neurosurgery, and Psychiatry, 62, 119–124.CrossRefGoogle ScholarPubMed
Singer, J. D. and Willett, J. B. (2003). Applied Longitudinal Data Analysis: Methods for Studying Change and Event Occurrence. New York, NY: Oxford University Press.Google Scholar
Tschanz, J. T., Welsh-Bohmer, K. A., Plassman, B. L., Norton, M. C., Wyse, B. W. and Breitner, J. C. (2002). An adaptation of the modified Mini-Mental State Examination: analysis of demographic influences and normative data: the Cache County study. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 15, 28–38.Google Scholar
Tschanz, J. T., Corcoran, C. D., Schwartz, S., Treiber, K., Green, R. C. and Norton, M. C. (2011). Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County dementia progression study. American Journal of Geriatric Psychiatry, 19, 532–542.Google Scholar
Uryu, K. et al. (2002). Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis. Journal of Neuroscience, 22, 446–454.Google Scholar
Van Den Heuvel, C., Thornton, E. and Vink, R. (2007). Traumatic brain injury and Alzheimer's disease: a review. Progress in Brain Research, 161, 303–316.Google Scholar
Van Duijn, C. M. et al. (1992). Head trauma and the risk of Alzheimer's disease. American Journal of Epidemiology, 135, 775–782.CrossRefGoogle ScholarPubMed
Welsh, K. A. et al. (1994). The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsychological battery. Neurology, 44, 609–614.Google Scholar
Werner, C. A. (2011). The Older Population: 2010 Census Briefs. US Census Bureau, C2010BR-09. Washington, DC: Economics and Statistics Administration – US Department of Commerce.Google Scholar