This article explores the motives of Ghana’s Trades Union Congress in securing development assistance during the era of decolonization and early independence. African interests and agency in these complex processes of negotiation have not been sufficiently untangled to highlight the decisions that African trade unionists made as they aligned with, and fostered, international networks and alliances to meet particular development goals. By highlighting the perspectives and actions of Ghana’s trade union officials, the article demonstrates what Africans sought to achieve through connections to international trade union organizations. The Ghana case illustrates the ways in which African trade unionists actively engaged in the variable and competing politics and policies of local, regional, and global trade unionism in order to strengthen their union apparatus and meet shifting needs.