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Copy number variation of WBP1L gene revealed its association with growth traits across Chinese cattle populations

Published online by Cambridge University Press:  02 September 2022

Jiaqiang Zhang ,
Zijing Zhang ,
Xian Liu ,
Yanan Chai ,
Peng Yang ,
Jungang Li ,
Yajun Huang ,
Lijuan Li ,
Weihong Huang  and
Guojie Yang
...Show all authors
Jiaqiang Zhang
Affiliation:
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China
Zijing Zhang
Affiliation:
Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou, Henan 450002, People's Republic of China
Xian Liu
Affiliation:
Henan Provincial Animal Husbandry General Station, Zhengzhou, Henan 450008, People's Republic of China
Yanan Chai
Affiliation:
Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou, Henan 450002, People's Republic of China
Peng Yang
Affiliation:
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China
Jungang Li
Affiliation:
Jiaxian Animal Husbandry Bureau, Jiaxian, Henan 467100, People's Republic of China
Yajun Huang
Affiliation:
Jiaxian Animal Husbandry Bureau, Jiaxian, Henan 467100, People's Republic of China
Lijuan Li
Affiliation:
Jiaxian Animal Husbandry Bureau, Jiaxian, Henan 467100, People's Republic of China
Weihong Huang
Affiliation:
Jiaxian Animal Husbandry Bureau, Jiaxian, Henan 467100, People's Republic of China
Guojie Yang
Affiliation:
Jiaxian Animal Husbandry Bureau, Jiaxian, Henan 467100, People's Republic of China
Zengfang Qi
Affiliation:
Jiaxian Animal Husbandry Bureau, Jiaxian, Henan 467100, People's Republic of China
Fuying Chen
Affiliation:
Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou, Henan 450002, People's Republic of China
Zhiming Li
Affiliation:
Henan Provincial Animal Husbandry General Station, Zhengzhou, Henan 450008, People's Republic of China
Chuzhao Lei
Affiliation:
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China
Qiaoting Shi
Affiliation:
Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou, Henan 450002, People's Republic of China
Baorui Ru
Affiliation:
Henan Provincial Animal Husbandry General Station, Zhengzhou, Henan 450008, People's Republic of China
Eryao Wang*
Affiliation:
Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou, Henan 450002, People's Republic of China
Yongzhen Huang*
Affiliation:
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China
*
Authors for correspondence: Eryao Wang, E-mail: eryaowang@outlook.com; Yongzhen Huang, E-mail: hyzsci@nwafu.edu.cn
Authors for correspondence: Eryao Wang, E-mail: eryaowang@outlook.com; Yongzhen Huang, E-mail: hyzsci@nwafu.edu.cn
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Abstract

Copy number variation (CNV) is a very common type of gene variation with high frequency. In recent years, CNV has been paid more attention in various fields, especially in livestock and poultry breeding, which has promoted the progress of breeding. WW domain binding protein 1-like (WBP1L) is a protein coding gene, which plays an important role in cattle populations, and its function has been extensively studied, but it is not clear whether the copy number of the gene can affect the growth and development of cattle populations. In this study, CNV of WBP1L gene was detected in 732 cattle of seven breeds (Qinchuan cattle, QC; Pinan cattle, PN; Yuengling cattle, YL; Xianan cattle, XN; Jiaxian cattle, JX; natural Guyuan cattle, NGY; Jian cattle, JA). In addition, the relationship between CNV and growth phenotype of cattle was studied. The experimental data indicate that the copy number of WBP1L was obviously correlated with heart girth of PN cattle (**P < 0.01), rump length (RL) and body weight (BW) of PN cattle (*P < 0.05), withers height (WH), RL, body length, chest depth and BW of JX cattle (*P < 0.05), WH of NGY cattle (*P < 0.05) and WH of JA cattle (*P < 0.05). It was proved that CNV of WBP1L gene could be used as molecular marker locus for genetic breeding of the above four cattle breeds.

Keywords

AssociationChinese cattlecopy number variations (CNVs)growth traitsWBP1L gene
Type
Animal Research Paper
Information
The Journal of Agricultural Science , Volume 160 , Issue 6 , December 2022 , pp. 528 - 534
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

These authors contributed equally to this work.

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