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Bounded Recurrence times and lead time in the design of a repetitive screening program

Published online by Cambridge University Press:  14 July 2016

Philip C. Prorok
Philip C. Prorok*
Affiliation:
National Cancer Institute
*
∗Postal address: Biometry Branch, National Cancer Institute, 5C19 Landow Building, National Institutes of Health, Bethesda, MD 20205, U.S.A.
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Abstract

An unsolved problem in the design of a repetitive screening trial is the determination of a procedure which yields the optimal number of screens for efficient evaluation. An approach to this problem described in this paper is to use lead time properties of cases detected at screening to define a stopping rule. Previous results are generalized by allowing the intervals between screens to be arbitrary, and the probability of detecting preclinical disease to vary among screens.

Keywords

REPETITIVE SCREENINGLEAD TIMEEARLY DETECTIONPROGRESSIVE DISEASE MODELPOINT PROCESSRECURRENCE TIME
Type
Research Paper
Information
Journal of Applied Probability , Volume 19 , Issue 1 , March 1982 , pp. 10 - 19
Copyright
Copyright © Applied Probability Trust 1982 

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References

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