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CONSANGUINEOUS MARRIAGES IN MOROCCO AND THE CONSEQUENCE FOR THE INCIDENCE OF AUTOSOMAL RECESSIVE DISORDERS

Published online by Cambridge University Press:  12 May 2009

I. CHERKAOUI JAOUAD ,
S. CHAFAÏ ELALAOUI ,
A. SBITI ,
F. ELKERH ,
L. BELMAHI  and
A. SEFIANI
I. CHERKAOUI JAOUAD
Affiliation:
Department of Medical Genetics, National Institute of Health, Rabat, Morocco
S. CHAFAÏ ELALAOUI
Affiliation:
Department of Medical Genetics, National Institute of Health, Rabat, Morocco
A. SBITI
Affiliation:
Department of Medical Genetics, National Institute of Health, Rabat, Morocco
F. ELKERH
Affiliation:
Department of Medical Genetics, National Institute of Health, Rabat, Morocco
L. BELMAHI
Affiliation:
Department of Medical Genetics, National Institute of Health, Rabat, Morocco
A. SEFIANI
Affiliation:
Department of Medical Genetics, National Institute of Health, Rabat, Morocco
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Summary

Consanguineous marriage is traditionally common throughout Arab countries. This leads to an increased birth prevalence of infants with recessive disorders, congenital malformations, morbidity and mortality. The aim of this study was to evaluate the rate of consanguineous marriage in families with autosomal recessive diseases, and to compare it with the average rate of consanguinity in the Moroccan population. The study was conducted in the Department of Medical Genetics in Rabat on 176 families with autosomal recessive diseases diagnosed and confirmed by clinical, radiological, enzymatic or molecular investigations. The rate of consanguinity was also studied in 852 families who had infants with trisomy 21 confirmed by karyotyping. These families were chosen because: (i) there is no association between trisomy 21 and consanguinity, (ii) these cases are referred from different regions of Morocco and (iii) they concern all social statuses. Among 176 families with autosomal recessive disorders, consanguineous marriages comprised 59.09% of all marriages. The prevalence of consanguinity in Morocco was found to be 15.25% with a mean inbreeding coefficient of 0.0065. The differences in the rates of consanguineous marriages were highly significant when comparing the general population and couples with offspring affected by autosomal recessive conditions. These results place Morocco among the countries in the world with high rates of consanguinity. Autosomal recessive disorders are strongly associated with consanguinity. This study better defines the health risks associated with consanguinity for the development of genetic educational guidelines targeted at the public and the health sector.

Type
Research Article
Information
Journal of Biosocial Science , Volume 41 , Issue 5 , September 2009 , pp. 575 - 581
Copyright
Copyright © Cambridge University Press 2009

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References

Al Husain, M. & Al Bunyan, M. (1997) Consanguineous marriages in a Saudi population and the effect of inbreeding on prenatal and postnatal mortality. Annals of Tropical Paediatrics 17, 155–160.Google Scholar
Alwan, A. & Modell, B. (1997) Community Control of Genetic and Congenital Disorders. EMRO Technical Publications, World Health Organization.Google Scholar
Baala, L., Briault, S., Etchevers, H. C., Laumonnier, F., Natiq, A., Amiel, J. et al. (2007) Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis. Nature Genetics 39, 454–456.CrossRefGoogle ScholarPubMed
Benallegue, A. & Kedji, F. (1984) Consanguinity and public health. Archives Françaises de Pédiatrie 41, 435–440.Google ScholarPubMed
Bittles, A. H. (1990) Consanguineous Marriage: Current Global Incidence and its Relevance to Demographic Research. URL: http://www.consang.net.Google Scholar
Bittles, A. H. (1994) Consanguinity as a demographic variable. Population and Development Review 20, 561–584.CrossRefGoogle Scholar
Bittles, A. H., Mason, W. M., Greene, J. & Rao, N. A. (1991) Reproductive behavior and health in consanguineous marriages. Science 252, 789–794.Google Scholar
Bosch, E., Calafell, F., Pérez-Lezaun, A., Clarimón, J., Comas, D., Mateu, E. et al. (2000) Genetic structure of north-west Africa revealed by STR analysis. European Journal of Human Genetics 8, 360–366.Google Scholar
Bouazzaoui, N. (1994) Consanguinity and public health in Morocco. Bulletin de l'Académie Nationale de Médecine 178, 1013–1025.Google Scholar
Cherkaoui, M., Baali, A., Larrouy, G., Sevin, A. & Boëtsch, G. (2005) Consanguinity, fertility of couples and mortality of children in the high Atlas population (commons of Anougal and Azgour, Marrakesh, Morroco). International Journal of Anthropology 20, 199–206.Google Scholar
Hafez, M., El-Tahan, H., Awadalla, M., El-Khayat, H., Abdel-Gafar, A. & Ghoneim, M. (1983) Consanguineous matings in the Egyptian population. Journal of Medical Genetics 20, 58–60.Google Scholar
Hami, H., Soulaymani, A. & Mokhtari, A. (2006) Endogamy, isonymy and consanguinity in the region of the Gharb-Chrarda-Béni Hssen (Morocco). Antropo Revista de Antropologia fisica 11, 223–233. URL: www.didac.ehu.es/antropo.Google Scholar
Hussain, R. (1999) Community perceptions of reasons for preference for consanguineous marriages in Pakistan. Journal of Biosocial Science 31, 449–461.CrossRefGoogle ScholarPubMed
Jaouad, I. C., Ouldim, K., Ali Ou Alla, S., Kriouile, Y., Villa, A. & Sefiani, A. (2008) Omenn syndrome with mutation in RAG1 gene. Indian Journal of Pediatrics 75, 944–946.CrossRefGoogle ScholarPubMed
Khlat, M. (1988) Consanguineous marriages in Beirut: time trends, spatial distribution. Social Biology 35, 324–330.Google ScholarPubMed
Riou, S., el Younsi, C. & Chaabouni, H. (1989) Consanguinity in the population of northern Tunisia. La Tunisie Médicale 67, 167–172.Google ScholarPubMed
Schulpen, T. W., Van Wieringen, J. C., Van Brummen, P. J., van Riel, J. M., Beemer, F. A., Westers, P. & Huber, J. (2006) Infant mortality, ethnicity, and genetically determined disorders in The Netherlands. European Journal of Public Health 16, 291–304.CrossRefGoogle ScholarPubMed
Talbi, J., Khadmaoui, A., Soulaymani, A. & Chafik, A. (2007) Study of consanguinity in Moroccan population. Influence on the profile of health. Antropo Revista de Antropologia fisica 15, 1–11. URL: www.didac.ehu.es/antropo.Google Scholar
Thompson, M. W., McInnes, R. R. & Willard, H. F. (1991) Genetics in Medicine. 5th edn. Saunders, London.Google Scholar