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A Study on genetic selection and haemoglobin heterozygotes: HB A/E and β-thalassaemia trait

Published online by Cambridge University Press:  31 July 2008

K. K. Bhattacharya ,
J. M. Sarkar ,
N. K. Das  and
A. K. Ghosh
K. K. Bhattacharya
Affiliation:
Anthropological Survey of India, Indian Museum, Calcutta, India
J. M. Sarkar
Affiliation:
Anthropological Survey of India, Indian Museum, Calcutta, India
N. K. Das
Affiliation:
Anthropological Survey of India, Indian Museum, Calcutta, India
A. K. Ghosh
Affiliation:
Anthropological Survey of India, Indian Museum, Calcutta, India
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Summary

In this paper the genetic fitness of the two heterozygotes Hb A/E and β-thalassaemia trait, in Calcutta, is examined in terms of their reproductive performance. It is found from fertility that the heterozygote Hb A/E enjoys some selective advantage over the normal homozygote Hb A/A, but the other heterozygote (β-thalassaemia trait) does not. But from overall reproductive performance (fertility and infant mortality together) it is postulated that the heterozygotes will eventually suffer from a selective disadvantage in a place like Calcutta, where malaria was eradicated about three decades ago.

Type
Research Article
Information
Journal of Biosocial Science , Volume 14 , Issue 4 , October 1982 , pp. 391 - 396
Copyright
Copyright © 1982, Cambridge University Press

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References

Allison, A.C. (1964) Polymorphism and natural selection in human populations. Cold Spring Harb. Symp. quant. Biol. 29, 137.CrossRefGoogle ScholarPubMed
Chatterjea, J.B. (1965) Thalassaemia: clinical and haematological aspects. Tringle, 7, 101.Google ScholarPubMed
Dacie, J.V. & Lewis, S.M. (1977) Practical Haematology, 5th edn.ELBS and Churchill Livingstone, Singapore.Google Scholar
Deka, R. (1975) Fertility and Hemoglobin Genotypes—a Population Study in Upper Assam. PhD thesis, Dibrugarh University. (Cited by Flatz, 1978).Google Scholar
Flatz, G. (1967) Hemoglobin E: distribution and population dynamics. Humangenetik, 3, 189.Google ScholarPubMed
Flatz, G. (1978) Population dynamics of hemoglobinopathies in Southeast Asia. In: Medical Genetics in India, Vol. 2, p. 191. Edited by Verma Auroma, I.C.Pondicherry.Google Scholar
Flatz, G., Pik, C. & Sringam, S. (1965) Haemoglobin E and β-thalassaemia: their distribution in Thailand. Ann. hum. Genet. 29, 151.CrossRefGoogle ScholarPubMed
Garn, S.M. (1961) Human Races. Thomas, Illinois.Google Scholar
Roberts, D.F. & Boyo, A. (1960) On the stability of haemoglobin gene frequencies in West Africa. Ann. hum. Genet. 24, 375.CrossRefGoogle ScholarPubMed
Weatherall, D.J. (1975) The genetics of the thalassaemias. In: Trends in Haematology, p 263. Edited by Sen, N.N. and Basu, A.K.Chatterjea Memorial Committee, Calcutta.Google Scholar