OBJECTIVES/GOALS: CTSA Search Solutions (https://ctsa-search.rutgers.edu/search/) is a database that allows users to systematically conduct structured searches among the 60+ CTSA hub websites for information related to NCATS goals and CTSA hub activities. It was created with the objective of providing a novel process to evaluating and benchmarking CTSA hubs. METHODS/STUDY POPULATION: The CTSA Search Solutions database is an information tool that includes structured search terms relating to 3 main CTSA categories: NCATS goals, CTSA activities, and COVID 19 information. Subcategories from these topics were also identified and organized. Each CTSA hub website was systematically searched for content related to each of the identified terms and categories. The uniform resource locator (URL) for the primary webpage that provided content for each term was collected and stored in the CTSA Search Solutions database for user friendly access. URLs are validated monthly for changes or discrepancies. RESULTS/ANTICIPATED RESULTS: The final database includes access to 63 CTSA Hub websites with 89 structured search term options and over 800 links collected, organized, and published. Hub content can be searched by state, region, or even hub age to make detailed comparisons with the data identified. The CTSA Search Solutions tool allows researchers, administrators, evaluators, and community partners to find the needed links, to learn about specific CTSA hub program highlights as well as conduct research into program hub outputs and best practices across the nationwide CTSA continuum. DISCUSSION/SIGNIFICANCE: On the most practical level, CTSA Search Solutions has the potential to help hub evaluators identify the content of hubs in their first cycle compared to those in their 3rd Cycle. It can help core leads determine common best practices. It can help researchers understand the variety of COVID 19 outreach among the CTSA continuum.