Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-02T23:01:44.981Z Has data issue: false hasContentIssue false
  • English
  • Français

Association of polymorphisms in exons 2 and 10 of the insulin-like growth factor 2 (IGF2) gene with milk production traits in Polish Holstein-Friesian cattle

Published online by Cambridge University Press:  29 September 2009

Emilia Bagnicka ,
Eulalia Siadkowska ,
Nina Strzałkowska ,
Beata Żelazowska ,
Krzysztof Flisikowski ,
Józef Krzyżewski  and
Lech Zwierzchowski
Emilia Bagnicka
Affiliation:
Institute of Genetics and Animal Breeding Polish Academy of Sciences, Jastrzębiec, Poland
Eulalia Siadkowska
Affiliation:
Institute of Genetics and Animal Breeding Polish Academy of Sciences, Jastrzębiec, Poland
Nina Strzałkowska
Affiliation:
Institute of Genetics and Animal Breeding Polish Academy of Sciences, Jastrzębiec, Poland
Beata Żelazowska
Affiliation:
Institute of Genetics and Animal Breeding Polish Academy of Sciences, Jastrzębiec, Poland
Krzysztof Flisikowski
Affiliation:
Institute of Genetics and Animal Breeding Polish Academy of Sciences, Jastrzębiec, Poland Technical University of Munich, Chair of Animal Breeding, Freising, Germany
Józef Krzyżewski
Affiliation:
Institute of Genetics and Animal Breeding Polish Academy of Sciences, Jastrzębiec, Poland
Lech Zwierzchowski*
Affiliation:
Institute of Genetics and Animal Breeding Polish Academy of Sciences, Jastrzębiec, Poland
*
*For correspondence; e-mail: l.zwierzchowski@ighz.pl
Get access Rights & Permissions [Opens in a new window]

Abstract

Insulin-like growth factor 2 (IGF2) is considered to be a regulator of post-natal growth and differentiation of the mammary gland. In the present work, associations of two single nucleotide polymorphisms in the bovine IGF2 gene with milk production traits were studied in dairy Holstein-Friesian cows: the already described g.8656C>T transition in exon 2 (RFLP-BsrI) and the newly found g.24507G>T transversion in exon 10 (RFLP-HaeIII), found by sequencing 273-bp exon 10 of the IGF2 gene in six individuals. Associations were analysed individually and in combination with the multi-trait repeatability test-day animal model. The CT/GT haplotype appeared to be associated with most of the milk traits studied (differences were significant at P⩽0·001). The most frequent CT/GG haplotype seemed inferior to others in fat and protein content and daily yield of fat and protein but superior (together with the TT/GG genotype) when the daily milk yield is considered.

Keywords

IGF2 genecattlepolymorphismmilkproduction
Type
Research Article
Information
Journal of Dairy Research , Volume 77 , Issue 1 , February 2010 , pp. 37 - 42
Copyright
Copyright © Proprietors of Journal of Dairy Research 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bäcklin, BM, Gessbo, A, Forsberg, M, Shokrai, A, Rozell, B & Engström, W 1998 Expression of the insulin-like growth factor II gene in polychlorinated biphenyl exposed female mink (Mustela vison) and their fetuses. Molecular Pathology 51 43–47CrossRefGoogle ScholarPubMed
Blundell, TL & Humbel, RE 1980 Hormone families: pancreatic hormones and homologous growth factors. Nature 287 781–787CrossRefGoogle ScholarPubMed
Brotherstone, S, White, IMS & Meyer, K 2000 Genetic modelling of daily milk yield using orthogonal polynomials and parametric curves. Animal Science 70 407–415CrossRefGoogle Scholar
Curchoe, C, Zhang, S, Bin, Y, Zhang, X, Yang, L, Feng, D, O'Neill, M & Cindy, XC 2005 Promoter-specific expression of the imprinted IGF2 gene in cattle (Bos taurus). Biology of Reproduction 73 1275–1281CrossRefGoogle ScholarPubMed
Dafgård, E, Bajaj, M, Honegger, AM, Pitts, J, Wood, S & Blundell, T 1985 The conformation of insulin-like growth factors: relationships with insulin. Journal of Cell Science 3(Suppl.) 53–64CrossRefGoogle ScholarPubMed
de Moor, CH, Meijer, H, Lissenden, S 2005 Mechanisms of translational control by the 3′ UTR in development and differentiation. Seminars in Cell & Developmental Biology 16 49–58CrossRefGoogle ScholarPubMed
Dindot, SV, Farin, PW, Farin, CE, Romano, J, Walker, S, Long, C & Piedrahita, J 2004 Epigenetic and genomic imprinting analysis in nuclear transfer derived Bos gaurus/Bos taurus hybrid fetuses. Biology of Reproduction 71 470–478CrossRefGoogle ScholarPubMed
Engström, W, Shokrai, A, Otte, K, Granérus, M, Gessbo, A, Bierke, P, Madej, A, Sjölund, M & Ward, A 1998 Transcriptional regulation and biological significance of the insulin like growth factor II gene. Cell Proliferation 31 173–189CrossRefGoogle ScholarPubMed
Flisikowski, K & Fries, R 2008 Bos taurus insulin (INS) and insulin-like growth factor 2 (IGF2) genes, complete cds. GenBank Acc. No EU518675Google Scholar
Flisikowski, K, Adamowicz, T, Maj, A, Hiendleder, S, Pareek, CH, Świtoński, M & Zwierzchowski, L 2005 Nucleotide sequence and variation of IGF2 gene exon 6 in Bos taurus and Bos indicus cattle. Animal Biotechnology 16 203–208CrossRefGoogle ScholarPubMed
Flisikowski, K, Adamowicz, T, Strabel, T, Jankowski, T, Świtonski, M & Zwierzchowski, L 2007 An InDel polymorphism in exon 6 of IGF2 is associated with the breeding value of Polish Holstein-Friesian bulls. Biochemical Genetics 45 139–143CrossRefGoogle ScholarPubMed
Goodall, JJ & Schmutz, SM 2003 Linkage mapping of IGF2 on cattle chromosome 29. Animal Genetics 34 313CrossRefGoogle ScholarPubMed
Goodall, JJ & Schmutz, SM 2007 IGF2 gene charcterization and association with rib eye area in beef cattle. Animal Genetics 38 154–161CrossRefGoogle Scholar
Hedley, PE, Dalin, AM & Engström, W 1989 Developmental regulation of insulin like growth factor II gene expression in the pig. Cell Biology International 13 857–862CrossRefGoogle ScholarPubMed
Heude, B, Ong, KK, Luben, R, Wareham, NJ & Sandhu, MS 2007 Study of association between common variation in the insulin-like growth factor 2 gene and indices of obesity and body size in middle-aged men and women. Journal of Clinical Endocrinology and Metabolism 92 2734–2738CrossRefGoogle ScholarPubMed
Hovey, RC, Harris, J, Hadsell, DL, Lee, AV, Ormandy, ChJ & Vonderhaar, BK 2003 Local insulin-like growth factor-II mediates prolactin-induced mammary gland development. Molecular Endocrinology 17 460–471CrossRefGoogle ScholarPubMed
Jarrige, R 1988 Feeding of cattle, sheep and goats. p. 471. Paris: INRAGoogle Scholar
Jeon, JT, Carlborg, O, Törnsten, A, Giuffra, E, Amarger, V, Chardon, P, Andersson-Eklund, L, Andersson, K, Hansson, I, Lundstrom, K & Andersson, L 1999 A paternally expressed QTL affecting skeletal and cardiac muscle mass in pigs maps to the IGF2 locus. Nature Genetics 21 157–158CrossRefGoogle Scholar
Joujou-Sisic, K, Granerus, M, Wetterling, H, Wikström, K, Engström, W, Jeffcott, L, Schofield, PN & Welin, A 1993 Developmental regulation of IGF II expression in the horse. Cell Biology International 16 603–607CrossRefGoogle Scholar
Kanai, N, Fujii, T, Saito, K & Yokoyama, T 1994 Rapid and simple method for preparation of genomic DNA from easily obtainable clotted blood. Journal of Clinical Pathology 47 1043–1044CrossRefGoogle ScholarPubMed
MacNeil, MD & Grosz, MD 2002 Genome-wide scans for QTL affecting carcass traits in Hereford×composite double backcross populations. Journal of Animal Science 80 2316–2324Google ScholarPubMed
Maj, A, Zwierzchowski, L, Oprządek, J, Oprządek, A & Dymnicki, E 2004 Polymorphism in the 5′-noncoding region of the bovine growth hormone receptor gene and its association with meat production traits in cattle. Animal Research 53 503–514CrossRefGoogle Scholar
Nezer, C, Moreau, L, Brouwers, B, Coppieter, SW, Detilleux, J, Hanset, R, Karim, L, Kvasz, A, Leroy, P & Georges, M 1999 An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs. Nature Genetic 21 155–156CrossRefGoogle Scholar
O'Dell, SD & Day, INM 1998 Molecules in focus: insulin-like growth factor II (IGF-II). International Journal of Biochemistry and Cell Biology 30 767–771CrossRefGoogle Scholar
Pickering, BM & Willis, AE 2005 The implications of structured 5′ untranslated regions on translation and disease. Seminars in Cell & Developmental Biology 16 39–47CrossRefGoogle ScholarPubMed
Prosser, CG, Davis, SR, Farr, VC, Moore, LG & Gluckman, PD 1994 Effects of close-arterial (external pudic) infusion of insulin-like growth factor-II on milk yield and mammary blood flow in lactating goats. Journal of Endocrinology 142 93–99CrossRefGoogle ScholarPubMed
Ron, M, Israeli, G, Seroussi, E, Weller, JI, Gregg, JP, Shani, M & Medrano, JF 2007 Combining mouse mammary gland gene expression and comparative mapping for the identification of candidate genes for QTL of milk production traits in cattle. BMC Genomics 8 183 (doi:10.1186/1471-2164-8-183)CrossRefGoogle ScholarPubMed
Schmutz, SM, Moker, JS, Gallagher, RS (Jr), Kappes, SM & Womack, JE 1996 In situ hybridization mapping of LDHA and IGF2 to cattle chromosome 29. Mammalian Genome 7 473CrossRefGoogle ScholarPubMed
Schofield, PN & Tate, VE 1987 Regulation of human IGF II transcription in fetal and adult tissues. Development 101 793–803CrossRefGoogle ScholarPubMed
Sherman, EL, Nkrumah, JD, Murdoch, BM, Li, C, Wang, Z, Fu, A & Moore, SS 2008 Polymorphisms and haplotypes in the bovine neuropeptide Y, growth hormone receptor, ghrelin, insulin-like growth factor 2, and uncoupling proteins 2 and 3 genes and their associations with measures of growth, performance, feed efficiency, and carcass merit in beef cattle. Journal of Animal Science 86 1–16CrossRefGoogle ScholarPubMed
Suzuki, H, Li, Y, Dong, X, Hassan, MM, Abbruzzese, JL & Li, D 2008 Effect of insulin-like growth factor gene polymorphisms alone or in interaction with diabetes on the risk of pancreatic cancer. Cancer Epidemiology, Biomarkers & Prevention 17 3467–3473CrossRefGoogle ScholarPubMed
Van Laere, A-S, Nguyen, M, Braunschweig, M, Nezer, C, Colette, C, Moreau, L, Archibald, AL, Haley, CS, Buys, N, Tally, M, Andersson, G, Georges, M & Andersson, L 2003 A regulatory mutation in IGF-2 causes a major QTL effect on muscle growth in the pig. Nature 425 832–836CrossRefGoogle Scholar
Werner, H, Adamo, M, Roberts, CT & Leroith, D 1994 Molecular and cellular aspects of insulin-like growth factor action. Vitamins and Hormones 48 1–58CrossRefGoogle ScholarPubMed
Zhao, Q, Davis, ME & Hines, HC 2002 Associations of an AciI polymorphism in the IGF-II gene with growth traits in beef cattle. 7th World Congress on Genetics Applied to Livestock Production, August 19–23, Montpellier, France Google Scholar
Supplementary material: PDF

Bagnicka supplementary material

Tables.pdf

Download Bagnicka supplementary material(PDF)
PDF 38.8 KB