Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-25T04:33:15.774Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of methionyl bovine somatotropin in a prolonged-release vehicle on milk production, hormone profiles and health in dairy cows

Published online by Cambridge University Press:  01 June 2009

Josef Škarda ,
Evžen Markalous ,
Josef Slaba ,
Petr Krejčí ,
Olga Škardová  and
Jiří Zedník
Josef Škarda
Affiliation:
Institute of Animal Physiology and Genetics, Czechoslovak Academy of Sciences, 104 00 Prague 10-Uhříněves, Czechoslovakia
Evžen Markalous
Affiliation:
Insiituie of Animal Production, Prague 10-Uhříněves, Czechoslovakia
Josef Slaba
Affiliation:
Institute of Animal Physiology and Genetics, Czechoslovak Academy of Sciences, 104 00 Prague 10-Uhříněves, Czechoslovakia
Petr Krejčí
Affiliation:
Institute of Animal Physiology and Genetics, Czechoslovak Academy of Sciences, 104 00 Prague 10-Uhříněves, Czechoslovakia
Olga Škardová
Affiliation:
State Veterinary Institute, Prague 6-Lysolaje, Czechoslovakia
Jiří Zedník
Affiliation:
Central Agricultural and Testing Institute, Prague 1-Těšnov, Czechoslovakia
Get access Rights & Permissions [Opens in a new window]

Summary

Milk production of dairy cows in 14 herds was increased by 3·8–32·1% by the administration of recombinant methionyl bovine somatotropin (bST) in a sustained-release vehicle at 14 d intervals at 40–94 d post partum. A greater response in multiparous than in primiparous cows was found in cows turned out to graze spring pasture. Administration of recombinant bST resulted in elevated plasma bST during the first 9 d after injection. Clinical characteristics such as respiration, heart rate and body temperature were unaffected by bST treatment, as were blood erythrocyte and leucocyte counts, haemoglobin concentrations and haematocrit values. Plasma levels of glucose, free fatty acids, urea and P, and serum alanine aminotransferase and aspartate aminotransferase were not affected by bST treatment, and acetone was not detected. No adverse effects of bST on general health, infection status of mammary glands, mastitis incidence and reproduction were found.

Type
Original Articles
Information
Journal of Dairy Research , Volume 59 , Issue 4 , November 1992 , pp. 499 - 506
Copyright
Copyright © Proprietors of Journal of Dairy Research 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Craven, N. 1990 The effects of sometribove on udder health. In Proceedings of the Monsanto Symposium Sometribove: mechanism of action, safety and instructions for use. Where do we stand ? Telfs, Austria, 1990Google Scholar
Dvorak, P., Bečka, S., Krejčí, P. & Chrpová, M. 1978 Radio-immunoassay of bovine growth hormone. Radiochemical and Radioanalytical Letters 34 155–159Google Scholar
Gertler, A., Ashkenazi, A. & Madar, Z. 1984 Binding sites of human growth hormone and ovine and bovine prolactins in the mammary gland and the liver of lactating dairy cow. Molecular and Cellular Endocrinology 34 51–57CrossRefGoogle ScholarPubMed
Hořejší, J. 1963 Základy klinické biochemie ve vnitřním lékařstvi. Praha: SZDNGoogle Scholar
National Research Council 1978 Nutrient Requirements of Dairy Cattle, 5th edn.Washington, DC: National Academy of SciencesGoogle Scholar
Oldenbroek, J. K., Garssen, G. J., Forbes, A. B. & Jonker, L. J. 1989 The effect of treatment of dairy cows of different breeds with recombinantly derived bovine somatotropin in a sustained-delivery vehicle. Livestock Production Science 21 13–34CrossRefGoogle Scholar
Peel, C. J., Eppard, P. J. & Hard, D. L. 1989 Evaluation of sometribove (methionyl bovine somatotropin) in toxicology and clinical trials in Europe and the United States. In Biotechnology in Growth Regulation, pp. 107–116 (Eds Heap, R. B., Presser, G. G. and Lamming, G. E.). London: ButterworthsCrossRefGoogle Scholar
Peel, C. J., Sandles, L. D., Quelch, K. J. & Herington, A. C. 1985 The effects of long term administration of bovine growth hormone on the lactational performance of identical-twin dairy cows. Animal Production 41 135–142Google Scholar
Phipps, B. H. 1989 A review of the influence of somatotropin on health, reproduction and welfare in lactating dairy cows. In Use of Somatotropin in Livestock Production, pp. 88–119 (Eds Sejrsen, K., Vestergaard, M. and Neimann-Sorensen, A.). London: Elsevier Applied ScienceGoogle Scholar
SAS 1982 SAS User's Guide: Statistics. Cary, NC: SAS Institute Inc.Google Scholar
Suarda, J. & Mader, H. 1991 Impact of bovine somatotropin on dairying in Eastern Europe. Journal of Dairy Science 74 Suppl. 2 72–82Google Scholar
Škarda, J., Urbanová, E., Bečka, S., Houdebine, L.-M., Delouis, C., Píchová, D., Pícha, J. & Bílek, J. 1982 Effect of bovine growth hormone on development of goat mammary tissue in organ culture. Endocrinologia Experimentalis 16 19–31Google ScholarPubMed
Trout, D. L., Estes, E. H. & Friedberg, S. J. 1960 Titration of free fatty acids of plasma: a study of current methods and a new modification. Journal of Lipid Research 1 199–202CrossRefGoogle Scholar