Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-26T22:16:40.320Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of sleep restriction during pregnancy on lipids and glucose homeostasis of female offspring submitted to ovariectomy

Published online by Cambridge University Press:  31 October 2018

Rogério Argeri ,
Diego Soares Carvalho ,
Beatriz Duarte Palma ,
Aparecida Emiko Hirata  and
Guiomar Nascimento Gomes Open the ORCID record for Guiomar Nascimento Gomes [Opens in a new window]
Rogério Argeri
Affiliation:
Department of Physiology,University Federal of São Paulo, UNIFESP, São Paulo – S.P., Brazil
Diego Soares Carvalho
Affiliation:
Department of Physiology,University Federal of São Paulo, UNIFESP, São Paulo – S.P., Brazil Federal Institute of Education in Science and Technology, Rondonia, Brazil
Beatriz Duarte Palma
Affiliation:
Centro Universitário São Camilo–São Paulo – S.P., Brazil
Aparecida Emiko Hirata
Affiliation:
Department of Physiology,University Federal of São Paulo, UNIFESP, São Paulo – S.P., Brazil
Guiomar Nascimento Gomes*
Affiliation:
Department of Physiology,University Federal of São Paulo, UNIFESP, São Paulo – S.P., Brazil
*
Address for correspondence: G. N. Gomes, Universidade Federal de Sao Paulo, Physiology, Rua Botucatu no 862, 5õ andar, Sao Paulo 04023-900, Brazil. E-mail: guiomar.gomes@unifesp.br
Get access Rights & Permissions [Opens in a new window]

Abstract

Sleep shortening during pregnancy may alter the mother’s environment, affecting the offspring. Thus, the present study evaluated the metabolic profile of female offspring from sleep-restricted rats during the last week of pregnancy. Pregnant Wistar rats were distributed into two groups: control (C) and sleep restriction (SR). The SR was performed 20 h/day, from 14th to 20th day of pregnancy. At 2 months, half of the offspring were subjected to ovariectomy (OVX); the others, to sham surgery. Studied groups were Csham, Covx, SRsham and SRovx. Cholesterol (HDL, LDL and C-total), triglycerides (TG) and glucose and insulin tolerance tests (GTT–ITT) were evaluated at 8 months. RSsham presented higher values of TG, while SRovx presented higher TG, LDL and C-total. Basal glucose concentration was increased in SRsham and SRovx. These data suggest that SR during pregnancy may be a risk factor for the development of diseases in adult female offspring.

Keywords

glycaemialipids profilematernal sleep restrictionoffspring
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 10 , Issue 3 , June 2019 , pp. 334 - 337
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Spiegel, K, Leproult, R, L’Hermite-Baleriaux, M, , et al. Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J Clin Endocrinol Metab. 2004; 89(11), 5762–5771.CrossRefGoogle ScholarPubMed
2. Spiegel, K, Knutson, K, Leproult, R, Tasali, E, Van Cauter, E. Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes. J Appl Physiol (1985). 2005; 99(5), 2008–2019.CrossRefGoogle ScholarPubMed
3. Gangwisch, JE, Heymsfield, SB, Boden-Albala, B, et al. Short sleep duration as a risk factor for hypertension: analyses of the first National Health and Nutrition Examination Survey. Hypertension. 2006; 47(5), 833–839.CrossRefGoogle ScholarPubMed
4. Schussler, P, Yassouridis, A, Uhr, M, et al. Growth hormone-releasing hormone and corticotropin-releasing hormone enhance non-rapid-eye-movement sleep after sleep deprivation. Am J Physiol Endocrinol Metab. 2006; 291(3), E549–E556.CrossRefGoogle ScholarPubMed
5. Spiegel, K, Leproult, R, Van Cauter, E. Impact of sleep debt on metabolic and endocrine function. Lancet. 1999; 354(9188), 1435–1439.CrossRefGoogle ScholarPubMed
6. Plagemann, A. A matter of insulin: developmental programming of body weight regulation. J Matern Fetal Neonatal Med. 2008; 21(3), 143–148.CrossRefGoogle ScholarPubMed
7. Pires, GN, Andersen, ML, Giovenardi, M, Tufik, S. Sleep impairment during pregnancy: possible implications on mother-infant relationship. Med Hypotheses. 2010; 75(6), 578–582.CrossRefGoogle ScholarPubMed
8. Pardo, GV, Goularte, JF, Hoefel, AL, et al. Effects of sleep restriction during pregnancy on the mother and fetuses in rats. Physiol Behav. 2016; 155, 66–76.CrossRefGoogle Scholar
9. Thomal, JT, Palma, BD, Ponzio, BF, et al. Sleep restriction during pregnancy: hypertension and renal abnormalities in young offspring rats. Sleep. 2010; 33(10), 1357–1362.CrossRefGoogle ScholarPubMed
10. Lima, IL, Rodrigues, AF, Bergamaschi, CT, et al. Chronic sleep restriction during pregnancy–repercussion on cardiovascular and renal functioning of male offspring. PLoS One. 2014; 9(11), e113075.CrossRefGoogle ScholarPubMed
11. Raimundo, JR, Bergamaschi, CT, Campos, RR, Palma, BD, Tufik, S, Gomes, GN. Autonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancy. Clinics (Sao Paulo). 2016; 71(9), 521–527.CrossRefGoogle ScholarPubMed
12. Argeri, R, Nishi, EE, Volpini, RA, Palma, BD, Tufik, S, Gomes, GN. Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring. Physiological reports. 2016; 4(16), e12888.CrossRefGoogle ScholarPubMed
13. Koban, M, Le, WW, Hoffman, GE. Changes in hypothalamic corticotropin-releasing hormone, neuropeptide Y, and proopiomelanocortin gene expression during chronic rapid eye movement sleep deprivation of rats. Endocrinology. 2006; 147(1), 421–431.CrossRefGoogle ScholarPubMed
14. Calegare, BF, Fernandes, L, Tufik, S, D’Almeida, V. Biochemical, biometrical and behavioral changes in male offspring of sleep-deprived mice. Psychoneuroendocrinology. 2009; 35(5), 775–784.CrossRefGoogle ScholarPubMed
15. Kapoor, A, Dunn, E, Kostaki, A, Andrews, MH, Matthews, SG. Fetal programming of hypothalamo-pituitary-adrenal function: prenatal stress and glucocorticoids. J Physiol. 2006; 572(Pt 1), 31–44.CrossRefGoogle ScholarPubMed
16. Seckl, JR, Meaney, MJ. Glucocorticoid programming. Annals of the New York Academy of Sciences. 2004; 1032, 63–84.CrossRefGoogle ScholarPubMed
17. McCormick, CM, Smythe, JW, Sharma, S, Meaney, MJ. Sex-specific effects of prenatal stress on hypothalamic-pituitary-adrenal responses to stress and brain glucocorticoid receptor density in adult rats. Brain Res Dev Brain Res. 1995; 84(1), 55–61.CrossRefGoogle ScholarPubMed
18 Bhatnagar, S, Lee, TM, Vining, C. Prenatal stress differentially affects habituation of corticosterone responses to repeated stress in adult male and female rats. Horm Behav. 2005; 47(4), 430–438.CrossRefGoogle ScholarPubMed
19. Szuran, TF, Pliska, V, Pokorny, J, Welzl, H. Prenatal stress in rats: effects on plasma corticosterone, hippocampal glucocorticoid receptors, and maze performance. Physiol Behav. 2000; 71(3–4), 353–362.CrossRefGoogle ScholarPubMed
20. Ignacio, DL, Fortunato, RS, Neto, RA, et al. Blunted response of pituitary type 1 and brown adipose tissue type 2 deiodinases to swimming training in ovariectomized rats. Hormone Metab Res = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2012; 44(11), 797–803.Google Scholar
21. Brown, LM, Clegg, DJ. Central effects of estradiol in the regulation of food intake, body weight, and adiposity. J Steroid Biochem Mol Biol. 2010; 122(1–3), 65–73.CrossRefGoogle ScholarPubMed
22. Geerling, JJ, Boon, MR, Kooijman, S, et al. Sympathetic nervous system control of triglyceride metabolism: novel concepts derived from recent studies. J Lipid Res. 2014; 55(2), 180–189.CrossRefGoogle ScholarPubMed