Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-22T23:20:34.087Z Has data issue: false hasContentIssue false
  • English
  • Français

Placental weight and foetal growth rate as predictors of ischaemic heart disease in a Swedish cohort

Published online by Cambridge University Press:  10 March 2014

A. Heshmati  and
I. Koupil
A. Heshmati*
Affiliation:
Centre for Health Equity Studies (CHESS), Stockholm University/Karolinska Institutet, Stockholm, Sweden
I. Koupil
Affiliation:
Centre for Health Equity Studies (CHESS), Stockholm University/Karolinska Institutet, Stockholm, Sweden
*
*Address for correspondence: A. Heshmati, Centre for Health Equity Studies (CHESS), Stockholm University/Karolinska Institutet, 106 91 Stockholm, Sweden. (Email amy.heshmati@chess.su.se)
Get access Rights & Permissions [Opens in a new window]

Abstract

Studies on placental size and cardiovascular disease have shown inconsistent results. We followed 10,503 men and women born in Uppsala, Sweden, 1915–1929 from 1964 to 2008 to assess whether birth characteristics, including placental weight and placenta/birth weight ratio, were predictive of future ischaemic heart disease (IHD). Adjustments were made for birth cohort, age, sex, mother’s parity, birth weight, gestational age and social class at birth. Placental weight and birth weight were negatively associated with IHD. The effect of placental weight on IHD was stronger in individuals from medium social class at birth and in those with low education. Men and women from non-manual social class at birth had the lowest risk for IHD as adults. We conclude that low foetal growth rate rather than placental weight was more predictive of IHD in the Swedish cohort. However, the strong effect of social class at birth on risk for IHD did not appear to be mediated by foetal growth rate.

Keywords

birth weightchildhood social classfoetal growthischaemic heart diseaseplacental weight
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 5 , Supplement 3 , June 2014 , pp. 164 - 170
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Kuh, D, Ben-Shlomo, Y, Lynch, J, Hallqvist, J, Power, C. Life course epidemiology. J Epidemiol Community Health. 2003; 57, 778–783.Google Scholar
2. Belkacemi, L, Nelson, DM, Desai, M, Ross, MG. Maternal undernutrition and fetal programming: role of the placenta. In The Placenta: From Development to Disease (eds. Kay HH, Nelson DM, Wang Y), 2011; pp. 1–9. Wiley-Blackwell: Oxford.Google Scholar
3. Barker, DJ. Fetal origins of coronary heart disease. BMJ. 1995; 311, 171–174.CrossRefGoogle ScholarPubMed
4. Belkacemi, L, Nelson, DM, Desai, M, Ross, MG. Maternal undernutrition influences placental-fetal development. Biol Reprod. 2010; 83, 325–331.CrossRefGoogle ScholarPubMed
5. Jansson, T, Powell, TL. Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches. Clin Sci (Lond). 2007; 113, 1–13.Google Scholar
6. Risnes, KR, Vatten, LJ, Baker, JL, et al. Birthweight and mortality in adulthood: a systematic review and meta-analysis. Int J Epidemiol. 2011; 40, 647–661.Google Scholar
7. Forsen, T, Eriksson, JG, Tuomilehto, J, et al. Mother’s weight in pregnancy and coronary heart disease in a cohort of Finnish men: follow up study. BMJ. 1997; 315, 837–840.Google Scholar
8. Fan, Z, Zhang, ZX, Li, Y, et al. Relationship between birth size and coronary heart disease in China. Ann Med. 2010; 42, 596–602.CrossRefGoogle ScholarPubMed
9. Barker, DJ, Gelow, J, Thornburg, K, et al. The early origins of chronic heart failure: impaired placental growth and initiation of insulin resistance in childhood. Eur J Heart Fail. 2010; 12, 819–825.Google Scholar
10. Eriksson, JG, Kajantie, E, Thornburg, KL, Osmond, C, Barker, DJ. Mother’s body size and placental size predict coronary heart disease in men. Eur Heart J. 2011; 32, 2297–2303.Google Scholar
11. Barker, DJ, Larsen, G, Osmond, C, et al. The placental origins of sudden cardiac death. Int J Epidemiol. 2012; 41, 1394–1399.Google Scholar
12. Barker, DJ, Thornburg, KL, Osmond, C, Kajantie, E, Eriksson, JG. The surface area of the placenta and hypertension in the offspring in later life. Int J Dev Biol. 2010; 54, 525–530.Google Scholar
13. Leon, DA, Lithell, HO, Vagero, D, et al. Reduced fetal growth rate and increased risk of death from ischaemic heart disease: cohort study of 15,000 Swedish men and women born 1915–29. BMJ. 1998; 317, 241–245.Google Scholar
14. Koupil, I, Leon, DA, Lithell, HO. Length of gestation is associated with mortality from cerebrovascular disease. J Epidemiol Community Health. 2005; 59, 473–474.Google Scholar
15. Martyn, CN, Barker, DJ, Jespersen, S, et al. Growth in utero, adult blood pressure, and arterial compliance. Br Heart J. 1995; 73, 116–121.Google Scholar
16. Eriksson, J, Forsen, T, Tuomilehto, J, Osmond, C, Barker, D. Fetal and childhood growth and hypertension in adult life. Hypertension. 2000; 36, 790–794.Google Scholar
17. Martyn, CN, Barker, DJ, Osmond, C. Mothers’ pelvic size, fetal growth, and death from stroke and coronary heart disease in men in the UK. Lancet. 1996; 348, 1264–1268.Google Scholar
18. Whincup, P, Cook, D, Papacosta, O, Walker, M. Birth weight and blood pressure: cross sectional and longitudinal relations in childhood. BMJ. 1995; 311, 773–776.Google Scholar
19. Taylor, SJ, Whincup, PH, Cook, DG, Papacosta, O, Walker, M. Size at birth and blood pressure: cross sectional study in 8–11 year old children. BMJ. 1997; 314, 475–480.Google Scholar
20. Barker, DJ, Bull, AR, Osmond, C, Simmonds, SJ. Fetal and placental size and risk of hypertension in adult life. BMJ. 1990; 301, 259–262.Google Scholar
21. Blumenshine, P, Egerter, S, Barclay, CJ, Cubbin, C, Braveman, PA. Socioeconomic disparities in adverse birth outcomes: a systematic review. Am J Prev Med. 2010; 39, 263–272.Google Scholar
22. Barker, DJ, Osmond, C, Forsen, TJ, Kajantie, E, Eriksson, JG. Maternal and social origins of hypertension. Hypertension. 2007; 50, 565–571.Google Scholar
23. Galobardes, B, Smith, GD, Lynch, JW. Systematic review of the influence of childhood socioeconomic circumstances on risk for cardiovascular disease in adulthood. Ann Epidemiol. 2006; 16, 91–104.CrossRefGoogle ScholarPubMed
Supplementary material: File

Heshmati and Koupil Supplementary Material

Supplementary Material

Download Heshmati and Koupil Supplementary Material(File)
File 27 KB