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Epigenetics and DOHaD: how translation to predictive testing will require a better public understanding

Published online by Cambridge University Press:  18 October 2021

Fiona Lynch Open the ORCID record for Fiona Lynch [Opens in a new window] ,
Sharon Lewis ,
Ivan Macciocca  and
Jeffrey M. Craig
Fiona Lynch
Affiliation:
Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Victoria, Australia Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia
Sharon Lewis
Affiliation:
Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Victoria, Australia Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia
Ivan Macciocca
Affiliation:
Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Victoria, Australia Victorian Clinical Genetics Services, Parkville, Victoria, Australia
Jeffrey M. Craig*
Affiliation:
Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Victoria, Australia Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia IMPACT – the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Faculty of Health, Deakin University, Waurn Ponds, Victoria, Australia
*
Address for correspondence: Jeffrey M. Craig, Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, VIC, Australia. Email: jeffrey.craig@deakin.edu.au
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Abstract

Epigenetics is likely to play a role in the mediation of the effects of genes and environment in risk for many non-communicable diseases (NCDs). The Developmental Origins of Health and Disease (DOHaD) theory presents unique opportunities regarding the possibility of early life interventions to alter the epigenetic makeup of an individual, thereby modifying their risk for a variety of NCDs. While it is important to determine how we can lower the risk of these NCDs, it is equally important to understand how the public’s knowledge and opinion of DOHaD and epigenetic concepts may influence their willingness to undertake such interventions for themselves and their children. In this review, we provide an overview of epigenetics, DOHaD, NCDs, and the links between them. We explore the issues surrounding using epigenetics to identify those at increased risk of NCDs, including the concept of predictive testing of children. We also outline what is currently understood about the public’s understanding and opinion of epigenetics, DOHaD, and their relation to NCDs. In doing so, we demonstrate that it is essential that future research explores the public’s awareness and understanding of epigenetics and epigenetic concepts. This will provide much-needed information which will prepare health professionals for the introduction of epigenetic testing into future healthcare.

Keywords

EpigeneticsDevelopmental Origins of Health and Diseasepublic opinionearly life originsfirst 1000 days
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 13 , Issue 4 , August 2022 , pp. 424 - 430
Copyright
© The Author(s), 2021. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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References

Cavalli, G, Heard, E. Advances in epigenetics link genetics to the environment and disease. Nature. 2019; 571(7766), 489–499.CrossRefGoogle Scholar
Morris, J, Gwinn, M, Clyne, M, Khoury, MJ. Public knowledge regarding the role of genetic susceptibility to environmentally induced health conditions. Community Genet. 2003; 6(1), 22–28.Google ScholarPubMed
Weaver, IC. Epigenetic programming by maternal behavior and pharmacological intervention. Nature versus nurture: let’s call the whole thing off. Epigenetics. 2007; 2, 22–28.CrossRefGoogle ScholarPubMed
Dupras, C, Ravitsky, V. The ambiguous nature of epigenetic responsibility. J Med Ethics. 2016; 42(8), 534–541.CrossRefGoogle ScholarPubMed
Lappé, M. Epigenetics, media coverage, and parent responsibilities in the post-genomic Era. Curr Genet Med Rep. 2016; 4(3), 92–97.CrossRefGoogle ScholarPubMed
Dolinoy, DC, Weidman, JR, Jirtle, RL. Epigenetic gene regulation: linking early developmental environment to adult disease. Reprod Toxicol. 2007; 23(3), 297–307.CrossRefGoogle ScholarPubMed
Greally, JM. A user’s guide to the ambiguous word ‘epigenetics’. Nat Rev Mol Cell Biol. 2018; 19(4), 207–208.CrossRefGoogle Scholar
Rothstein, MA, Cai, Y, Marchant, GE. The ghost in our genes: legal and ethical implications of epigenetics. Health Matrix. 2009; 19, 1–62.Google ScholarPubMed
Scott, S. Parenting quality and children’s mental health: biological mechanisms and psychological interventions. Curr Opin Psychiatry. 2012; 25(4), 301–306.CrossRefGoogle ScholarPubMed
Richardson, SS, Daniels, CR, Gillman, MW, et al. Society: don’t blame the mothers. Nature. 2014; 512(7513), 131–132.CrossRefGoogle ScholarPubMed
Nestler, EJ. Stress makes its molecular mark. Nature. 2012; 490(7419), 171–172.CrossRefGoogle ScholarPubMed
Vanhees, K, Vonhogen, IG, van Schooten, FJ, Godschalk, RW. You are what you eat, and so are your children: the impact of micronutrients on the epigenetic programming of offspring. Cell Mol Life Sci. 2013; 71(2), 271–285.CrossRefGoogle ScholarPubMed
Godfrey, KM, Lillycrop, KA, Burdge, GC, Gluckman, PD, Hanson, MA. Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr Res. 2007; 61(5 Part 2), 5R–10R.CrossRefGoogle ScholarPubMed
Hughes, V. Epigenetics: the sins of the father. Nature. 2014; 507(7490), 22–24.CrossRefGoogle ScholarPubMed
Gluckman, PD, Hanson, MA, Beedle, AS. Non-genomic transgenerational inheritance of disease risk. BioEssays. 2007; 29, 145–154.CrossRefGoogle ScholarPubMed
Jirtle, RL, Skinner, MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet. 2007; 8(4), 253–262.CrossRefGoogle ScholarPubMed
Rothstein, MA. Epigenetic exceptionalism. J Law Med Ethics. 2013; 41(3), 733–736.CrossRefGoogle ScholarPubMed
Chadwick, R, O’Connor, A. Epigenetics and personalized medicine: prospects and ethical issues. Per Med. 2013; 10(5), 463–471.CrossRefGoogle ScholarPubMed
Moore, T, Arefadib, N, Deery, A, Sue West, M. The first thousand days: An evidence paper - Summary. (2017); Parkville, Victoria: Centre for Community Child Health, Murdoch Children’s Research Institute .Google Scholar
Lumey, LH, van Poppel, FWA. The dutch famine of 1944-45 as a human laboratory: Changes in the early life environment and adult health. In Early Life Nutrition, Adult Health and Development: Lessons from Changing Diets, Famines and Experimental Studies (eds. Lumey, LH, Vaiserman, A), 2013; pp. 59–76. Nova Science Publishers, New York.Google Scholar
Jablonka, E, Lamb, MJ. The changing concept of epigenetics. Ann N Y Acad Sci. 2002; 981, 82–96.CrossRefGoogle ScholarPubMed
Barker, D. The developmental origins of adult disease. J Am Coll Nutr. 2004; 23(sup6), 588S–595S.CrossRefGoogle ScholarPubMed
Bay, JL, Mora, HA, Sloboda, DM, Morton, SM, Vickers, MH, Gluckman, PD. Adolescent understanding of DOHaD concepts: a school-based intervention to support knowledge translation and behaviour change. J Dev Orig Health Dis. 2012; 3(6), 469–482.CrossRefGoogle ScholarPubMed
Roseboom, TJ, van der Meulen, JHP, Ravelli, ACJ, Osmond, C, Barker, DJP, Bleker, OP. Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. Mol Cell Endocrinol. 2001; 185(1-2), 93–98.CrossRefGoogle Scholar
Mameli, C, Mazzantini, S, Zuccotti, GV. Nutrition in the first 1000 days: the origin of childhood obesity. Int J Environ Res Public Health. 2016; 13(9), 838.CrossRefGoogle ScholarPubMed
Jacob, CM, Hanson, M. Implications of the Developmental Origins of Health and Disease (DOHaD) concept for policy-making. Curr Opin Endocr Metab Res. 2020; 13(supp1), 20–27.CrossRefGoogle Scholar
Egger, G, Liang, G, Aparicio, A, Jones, PA. Epigenetics in human disease and prospects for epigenetic therapy. Nature. 2004; 429(6990), 457–463.CrossRefGoogle ScholarPubMed
Jiang, Y-H, Bressler, J, Beaudet, AL. Epigenetics and human disease. Annu Rev Genomics Hum Genet. 2004; 5(1), 479–510.CrossRefGoogle ScholarPubMed
Peedicayil, J. The epigenome in personalized medicine. Clin Pharmacol Ther. 2013; 93(2), 149–150.CrossRefGoogle ScholarPubMed
WHO. Noncommunicable Diseases: World Health Organization 2021, https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases.Google Scholar
Barker, D, Barker, M, Fleming, T, Lampl, M. Developmental biology: support mothers to secure future public health. Nature. 2013; 504(7479), 209–211.CrossRefGoogle ScholarPubMed
Hanson, MA, Gluckman, PD, Godfrey, KM. Developmental epigenetics and risks of later non-communicable disease. In Hormones, Intrauterine Health and Programming. vol. 12, Seckl, JR, Christen, Y), 2014; pp. 175–183. Springer International Publishing, Switzerland.CrossRefGoogle Scholar
Gluckman, PD, Hanson, MA, Low, FM. The role of developmental plasticity and epigenetics in human health. Birth Defects Res C Embryo Today. 2011; 93(1), 12–18.CrossRefGoogle ScholarPubMed
Riley, L, Guthold, R, Cowan, M, et al. The World Health Organization STEPwise approach to noncommunicable disease risk-factor surveillance: methods, challenges, and opportunities. Am J Public Health. 2016; 106(1), 74–78.CrossRefGoogle ScholarPubMed
Hanson, MA, Gluckman, PD. Developmental origins of health and disease - Global public health implications. Best Pract Res Clin Obstet Gynaecol. 2015; 29(1), 24–31.CrossRefGoogle ScholarPubMed
Park, M, Kobor, MS. The potential of social epigenetics for child health policy. Can Public Policy. 2015; 41(Supplement 2), S89–S96.CrossRefGoogle Scholar
Sharp, GC, Relton, CL. Epigenetics and noncommunicable diseases. Epigenomics. 2017; 9(6), 789–791.CrossRefGoogle ScholarPubMed
Murray, R, Bryant, J, Titcombe, P, et al. DNA methylation at birth within the promoter of ANRIL predicts markers of cardiovascular risk at 9 years. Clin Epigenetics. 2016; 8(1), 1–6.CrossRefGoogle ScholarPubMed
Heyn, H, Méndez-González, J, Esteller, M. Epigenetic profiling joins personalized cancer medicine. Expert Rev Mol Diagn. 2013; 13(5), 473–479.CrossRefGoogle ScholarPubMed
Weber, WW. The promise of epigenetics in personalized medicine. Mol Interv. 2010; 10(6), 363–370.CrossRefGoogle ScholarPubMed
Fang, CY, Dunkel-Schetter, C, Tatsugawa, ZH, et al. Attitudes toward genetic carrier screening for cystic fibrosis among pregnant women: the role of health beliefs and avoidant coping style. Women’s Health. 1997; 3(1), 31–51.Google ScholarPubMed
Rosenstock, IM. Why people use health services. Milbank Q. 1966; 44(3), 94–127.CrossRefGoogle ScholarPubMed
Condit, CM. Public understandings of genetics and health. Clin Genet. 2010; 77(1), 1–9.CrossRefGoogle ScholarPubMed
Dubois, M, Louvel, S, Le Goff, A, Guaspare, C, Allard, P. Epigenetics in the public sphere: interdisciplinary perspectives. Environ Epigenet. 2019; 5(4), 5.CrossRefGoogle ScholarPubMed
Tercyak, KP, Hensley Alford, S, Emmons, KM, et al. Parents’ attitudes toward pediatric genetic testing for common disease risk. Pediatrics. 2011; 127(5), e1288–e1295.CrossRefGoogle ScholarPubMed
Smerecnik, CMR, Mesters, I, de Vries, NK, de Vries, H. Educating the general public about multifactorial genetic disease: applying a theory-based framework to understand current public knowledge. Genet Med. 2008; 10(4), 251–258.CrossRefGoogle ScholarPubMed
Fallat, ME, Katz, AL, Mercurio, MR, et al. Ethical and policy issues in genetic testing and screening of children. Pediatrics. 2013; 131(3), 620–622.Google Scholar
Campbell, E, Ross, LF. Parental attitudes and beliefs regarding the genetic testing of children. Community Genet. 2005; 8(2), 94–102.Google ScholarPubMed
Segal, ME, Polansky, M, Sankar, P. Adults’ values and attitudes about genetic testing for obesity risk in children. Int J Pediatr Obes. 2007; 2(1), 11–21.CrossRefGoogle ScholarPubMed
Shkedi-Rafid, S, Fenwick, A, Dheensa, S, Lucassen, AM. Genetic testing of children for adult-onset conditions: opinions of the British adult population and implications for clinical practice. Eur J Hum Genet. 2015; 23(10), 1281–1285.CrossRefGoogle ScholarPubMed
Tarini, BA, Singer, D, Clark, SJ, Davis, MM. Parents’ interest in predictive genetic testing for their children when a disease has no treatment. Pediatrics. 2009; 124(3), e432–e8.CrossRefGoogle ScholarPubMed
Etchegary, H, Dicks, E, Green, J, Hodgkinson, K, Pullman, D, Parfrey, P. Interest in newborn genetic testing: a survey of prospective parents and the general public. Genet Test Mol Biomarkers. 2012; 16(5), 353–358.CrossRefGoogle ScholarPubMed
McKerracher, L, Moffat, T, Barker, M, Williams, D, Sloboda, DM. Translating the Developmental Origins of Health and Disease concept to improve the nutritional environment for our next generations: a call for a reflexive, positive, multi-level approach. J Dev Orig Health Dis. 2019; 10(4), 420–428.CrossRefGoogle Scholar
Bay, JL, Vickers, MH, Mora, HA, Sloboda, DM, Morton, SM. Adolescents as agents of healthful change through scientific literacy development: a school-university partnership program in New Zealand. Int J STEM Educ. 2017; 4(1), 15.CrossRefGoogle ScholarPubMed
Bay, J, Vickers, M. Adolescent education: an opportunity to create a Developmental Origins of Health and Disease (DOHaD) circuit breaker. J Dev Orig Health Dis. 2016; 7(5), 501–504.CrossRefGoogle ScholarPubMed
Bateson, P, Barker, D, Clutton-Brock, T, et al. Developmental plasticity and human health. Nature. 2004; 430(6998), 419–421.CrossRefGoogle ScholarPubMed
Holliday, R. Epigenetics: a historical overview. Epigenetics. 2006; 1(2), 76–80.CrossRefGoogle ScholarPubMed