Boundary-layer instability and transition control have drawn extensive attention from the hypersonic community. The acoustic metasurface has become a promising passive control method, owing to its straightforward implementation and lack of requirement for external energy input. Currently, the effects of the acoustic metasurface on the early and late transitional stages remain evidently less understood than the linear instability stage. In this study, the transitional stage of a flat-plate boundary layer at Mach 6 is investigated, with a particular emphasis on the nonlinear mode–mode interaction. The acoustic metasurface is modelled by the well-validated time-domain impedance boundary condition. First, the resolvent analysis is performed to obtain the optimal disturbances, which reports two peaks corresponding to the oblique first mode and the planar Mack second mode. These two most amplified responses are regarded as the dominant primary instabilities that trigger the transition. Subsequently, both optimal forcings are introduced upstream in the direct numerical simulation, which leads to pronounced detuned modes before breakdown. The takeaway is that the location of the acoustic metasurface is significant in minimising skin friction and delaying transition onset simultaneously. The bispectral mode decomposition results reveal the dominant energy-transfer routine along the streamwise direction – from primary modes to low-frequency detuned modes. By employing the acoustic metasurface, the nonlinear triadic interaction between high- and low-frequency primary modes is effectively suppressed, ultimately delaying transition onset, whereas the late interaction related to lower-frequency detuned modes is reinforced, promoting the late skin friction. The placement of the metasurface in the linearly unstable region of the second mode delays the transition, which is due to the suppressed streak in the oblique breakdown scenario. However, in the late stage of the transition, the acoustic metasurface induces an undesirable increment of skin friction overshoot due to the augmented shear-induced dissipation work, which mainly arises from reinforced detuned modes related to the combination resonance. Meanwhile, by restricting the location of the metasurface upstream of the overshoot region, this undesirable augmentation of skin friction can be eliminated. As a result, the reasonable placement of the metasurface is crucial to damping the early instability while causing less negative impacts on the late transitional stage.