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Effect of selenium and Ascaridia galli infection on antioxidant biomarkers in broiler chickens: a mathematical model for parasite reduction and host growth

Published online by Cambridge University Press:  01 December 2007

M. Gabrashanska ,
M. Galvez-Morros ,
S.E. Teodorova ,
S. Ermidou-Pollet  and
S. Pollet
M. Gabrashanska
Affiliation:
Institute for Experimental Pathology and Parasitology, Bulgarian Academy of Sciences, Acad., G. Bonchev str., bl. 25, 1113 Sofia, Bulgaria
M. Galvez-Morros
Affiliation:
Departamento de Quimica Analitica, Facultad de Ciencias Quimicas, Universidad Complutense, Ciudad Universitaria, 28040 Madrid, Spain
S.E. Teodorova*
Affiliation:
Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, 72, Tzarigradsko shaussee, 1784 Sofia, Bulgaria
S. Ermidou-Pollet
Affiliation:
University of Medicine, Medical School, 73, Mikras Asias Str., Athens, Greece
S. Pollet
Affiliation:
University of Medicine, Medical School, 73, Mikras Asias Str., Athens, Greece
*
*Fax: +3592 975 36 19 E-mail: seteodor@tea.bg
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Abstract

The activity of selenium-dependent glutathione peroxidase (GPX), liver concentration of vitamin E, and plasma and liver selenium levels were used for estimation of the antioxidant status of broiler chickens infected with Ascaridia galli. These biomarkers were recorded in an experiment covering 70 days p.i. At the same time the establishment rate of A. galli in chicken intestines, gain in the host body weight and chicken survival were studied. Broiler chickens (Cobb hybrids) were infected with 1450 embryonated A. galli eggs and treated with Sel-plex. A mathematical model was applied to determine the rate of nematode reduction and the relative rate of gain of host body weight, which are essential kinetic parameters of parasite–host interaction. The activity of GPX increased with both elevated selenium and reduced infection levels. The concentrations of selenium and vitamin E, and the GPX activity in the infected chickens demonstrated a similar pattern of change with time after day 30 p.i. The supplementation of the broilers with dietary selenium in the form of Sel-plex improved their antioxidant status. Increases by 29% in vitamin E concentration, 15% in GPX activity, and 22% in liver selenium concentration, respectively, were recorded in the infected and treated, compared to infected and untreated broilers.

Type
Research Papers
Information
Journal of Helminthology , Volume 81 , Issue 4 , December 2007 , pp. 399 - 408
Copyright
Copyright © Cambridge University Press 2007

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