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Further studies on the effect of cyclosporin A on the course of Paragonimus infection in rats

Published online by Cambridge University Press:  05 June 2009

Yoshihisa Hashiguchi  and
Yoshisuke Okamura
Yoshihisa Hashiguchi
Affiliation:
Department of Parasitology, Kochi Medical School, Nankoku City, Kochi 781–51, Japan
Yoshisuke Okamura
Affiliation:
Department of Parasitology, Kochi Medical School, Nankoku City, Kochi 781–51, Japan
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Abstract

Paragonimus ohirai-infected rats were treated with cyclosporin A (CyA) at different times during the course of infection. CyA (5×80 mg/kg) affected the worm recovery, growth and maturation rates of P. ohirai with respect to control values. This tendency was most remarkable in animals treated 15 days and more after infection with CyA (groups B, +15 to +19 days; C, +25 to +29; D, +35 to +39 and E, +45 to +49). In group A (0 to +4), however, the drug did not affect markedly the growth and maturation of worms, although it significantly lowered worm recovery rates. CyA administration also affected normal migration of P. ohirai in the highly susceptible host (rat), when the drug was administered during the peritoneal and/or liver phase of infection. Thus, in this P. ohirai/rat model, CyA significantly reduced worm recovery rates, and affected the growth, maturation and migration of the worms depending on the time of administration.

Keywords

Paragonimus ohiraicyclosporin Aratimmunosuppressants
Type
Research Article
Information
Journal of Helminthology , Volume 63 , Issue 4 , December 1989 , pp. 328 - 332
Copyright
Copyright © Cambridge University Press 1989

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